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I don't know, personally I wouldn't touch mescaline even if a shaman offered it to me in the middle of the desert... what kind of answers are you actually looking for here?
I honestly believe the best approach is mental reprogramming. To actually change anything, you first have to pinpoint exactly which limiting beliefs are holding you back. Simple meditation or basic exercises can help you identify those negative patterns. Once you know what they are, you can use autohypnosis or autosuggestion to rewire them. But look, you have to be consistent. It’s just like hitting the gym three times a week or sticking to a clean diet—you won't see results without persistence. If you want to purge those subconscious roadblocks, this is how you do it. Also, don't sleep on your dreams; I highly recommend journaling them and actually analyzing what they mean.
Anyway, that's just my take. I'm no expert...