Posts by crimsonviper48

Ethan Clark3 said:Could schizophrenia actually stem from mitochondrial damage (our cells' energy source)?
It seems like more and more research is pointing toward this theory, and I guess the same might apply to bipolar disorder and depression too.
For example, check this out: https://pubmed.ncbi.nlm.nih.gov/25446950/#:~:text=Mitochondrial%20deficit%2C%20altered%20re dox%20balance,to%20neuroprogressive%20changes%20in %20schizophrenia.
Mitochondria are pretty vital for regulating cell functions, like bioenergetics, calcium homeostasis, redox signaling, and programmed cell death. They also seem essential for various aspects of neurodevelopment and how neurons function.

That said, if mitochondria are damaged, it could mess with brain bioenergetics during development and alter critical neural processes, which might lead to neurodevelopmental issues. One widely accepted mechanism linked to the neurodevelopmental roots of schizophrenia is an immune inflammatory pathway. However, I suppose we still don't fully understand the exact source of that inflammation or the underlying neurobiological mechanisms behind schizophrenia.

Recent findings suggest that disruptions in mitochondrial network dynamics might lead to various nervous system disorders involving inflammatory pathologies. In schizophrenia, we see mitochondrial deficits, altered redox balance, and chronic low-grade inflammation. It’s possible that responses to oxidative or nitrosative stress caused by mitochondrial dysfunction could trigger those immune pathways, potentially leading to neuroprogressive changes. We're basically looking at how genomics, proteomics, and imaging studies all seem to support the idea that mitochondrial damage plays a role in the development of schizophrenia.

So, maybe mainstream medicine should consider ways to improve mitochondrial function for schizophrenia and similar conditions, rather than just focusing on lowering dopamine levels?

To quote Dietary Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health : At any rate, several studies have shown that ketogenic diets can increase mitochondrial content, and plenty of research suggests these diets boost the expression, amount, or activity of mitochondrial proteins involved in oxidative phosphorylation and fat oxidation.

Plus, sugar isn't just bad for our waistlines and teeth; it's also tough on our mitochondria and contributes to various metabolic health issues. Consuming too much sugar puts stress on the mitochondria, causing them to release free radicals. I think that's what they call oxidative damage.

Just one question... are Modafinil and Pramipexole less harmful, or is it all essentially the same thing?

Harold Anderson3 said:Are you saying you've lived with schizophrenia for 22 years, or that you're 22 years old, or that you're a "young" 22-year-old, or maybe that you've been hospitalized twice a year for 22 years?

I'm honestly a little lost here; I can't make heads or tails of what you're trying to tell me about being 22. 🤷

Well, I'm 22, and I've been in treatment since 2012... first for depression, and now it's schizophrenia and borderline personality disorder... yeah, that's it...

Why is it that I end up back in the hospital twice a year... I take my meds regularly, though honestly, I rarely actually swallow them... Not that alcohol has ever made me feel physically sick or sent me into a depressive spiral, either, but I know I can overdo it sometimes, and god, I’m only 22... It just doesn't make sense. I can't tell if it's my borderline personality disorder tearing me apart, or if it's schizophrenia, or maybe they're just teaming up against me... Therapy helps, specifically small group sessions, but still... ending up in the ER twice a year is just way too much...

Nicole Booth25 said:Is there any possibility that Xeplion could cause neuropathy as a side effect?

Oh, absolutely... especially with most of those newer antipsychotics on the market. That’s why I personally stick to the older stuff like Moditen or Prasil... I just can't deal with the newer ones. Every single one I've tried has messed me up... my sinuses swell up, or my heart starts racing, or I get these pounding headaches that just won't quit. In my experience, the older medications really are better...🙂😵

I’m sure most of you saw that video of the guy claiming he was miraculously healed from schizophrenia through divine intervention... the guy just keeps going on and on about how he used every substance under the sun, and then suddenly, once he stops, "miracles" happen. Honestly, whoever gave him that diagnosis missed the mark entirely; it sounds more like a psychotic break triggered by MDMA and heavy trips. Schizophrenia implies you're dealing with it even when you're sober, logically speaking... so please, don't fall for that religious propaganda or those clickbait headlines, there's no magic fix here. I actually have a friend with the same diagnosis who tells me straight up that he’s never had a single hallucination, so how on earth would he see God? Anyway, my doctor just discontinued that nasty Quetiapine because of the heart palpitations and weight gain issues... and she bumped my Prozac up to 125mg. I'm honestly not sure if I'll even be able to sleep tonight since Quetiapine hits you so hard, whereas Prozac and the other stuff feel like nothing at all... god, I love rambling to you guys

Sandra Lee2 said:Why act so strange?

What do you mean, what's weird about me... I'll just tell you straight... ever since I lit up my first joint back in 2016, it’s been this slow slide into a void... like you lose the ability to actually think for yourself... everything just becomes automatic... mindless...

😵 I’m still stuck in this loop of derealization and depersonalization... plus that heavy sense of emptiness, you know? It's all because of the BPD. I don't even know who can truly get it, but for me, it just doesn't stop. I'm constantly in this state of derealization where everything feels... I don't know, like a flat line, like you're sensing things but they aren't really there...

Is anyone even active on here anymore? I’m curious about something... what I see when I close my eyes... because the first unnatural thing I saw while my eyes were wide open was death. I was only six years old back then... and I used to have these night terrors, but God would always give me this guidance... I listened to Him, and honestly, things just worked out better for me in life... once, I actually slipped on some soap in the bathroom and it was almost over—I was falling straight onto my back—but then this invisible force just caught me and set me right again. I just said, "Thank you, God." It happened when I was only six... anyway, getting back to the point, does anyone else see things behind their eyelids at night? Like visions of martyrs in hell or demons and stuff... has anyone else experienced this? To me, it doesn't even feel like schizophrenia, it just feels... strange. These antipsychotics sort of numb me out, they make me feel dead inside, specifically Qpin... but if I just take Modafinil and Prazin, it’s like I haven't taken anything at all.

Honestly, you guys... I’m just sitting here reading this forum today and man, I thought I was the one dealing with schizophrenia, but you all have truly mastered what the professionals call "word salad"... I am genuinely lost tonight. My eyes were jumping from the second line to the third trying to make sense of anything, but nothing connects... anyway, how are you all doing? As for me, I'm somewhere in the middle. I stay on my meds, though the psychosis still creeps back in sometimes. It’s not really voices for me, though... I think I heard actual voices maybe four times in the last three years. For me, it's more like when I close my eyes to sleep, things start happening... like driving through a desert, or little people dancing around a campfire, or flaming skulls and demons... it’s terrifying. And then there's the paranoia, mostly when I'm riding the subway or the bus. My first psychotic break was surreal... I was busy working, judging people, when suddenly, out of nowhere, it felt like the Virgin Mary appeared and told me, "Don't worry, dear child, the world will end in 2035." The second time was this strange light that kept shifting colors, like a weird sun reflection... it was so disorienting. The floorboards even started warping and bending... nothing too crazy at the time, I guess. I didn't even realize I was losing it; I just figured, okay, I saw what I saw, let's move on. But when the panic attacks started hitting, I couldn't handle it anymore. That was probably the first time I actually saw a psychiatrist... or maybe my GP sent me after a hallucination, I can't quite remember. I just remember being on an IV drip that felt so incredible, like I had stepped straight into heaven... who knows what they gave me. I spent six stints at the local psychiatric hospital and, well, that's my story. Alongside the schizo, I've got borderline too.