Lown–Ganong–Levine syndrome (LGL)

During my cardiology appointment, the doctor took one look at my EKG and mentioned he suspects I might have LGL syndrome. Does anyone here actually know anything about this condition? How serious are we talking? They’ve put me on 25mg of Ormidol to help manage the symptoms, specifically the tachycardia episodes. Where can I find some reliable information to read up on this?

I’m not totally sure, but I think this might be the same thing as WPW syndrome. Honestly, just try searching for it on Google. And hey, please don't freak out until a doctor gives you a definitive answer. Even when they do, they usually tell you it’s not actually that big of a deal. Don't panic—they aren't even certain yet, and if it does turn out to be WPW (assuming it's even the same thing), it often doesn't even require treatment. If it does, there are pills that handle it perfectly fine, and if not, there's surgery, but I really believe you won't even need anything. Definitely get your thyroid checked out, too, and please, try not to stress too much—you're only making things harder on yourself. Hang in there and good luck!

From what I’ve gathered, the main thing separating WPW syndrome from LGL seems to be some kind of delta wave discrepancy. As for what that actually signifies—honestly, I haven't the slightest clue. I just know I need to keep my hormones in check, especially since I'm dealing with subclinical hyperthyroidism. Anyway, thanks for getting back to me!

I honestly think there’s a pretty strong link between this and hyperthyroidism. To me, it looks like that delta wave is basically signaling some extra little detour the heart signal takes instead of just following the standard route. My doctors told me not to freak out about it, though. They actually suspected WPW at first, but once they finished my Holter monitor test, it turned out to be nothing more than extrasystoles—everything else was mostly fine. So, I ended up being prescribed Concor Cor at 1.25mg, and now I’m just sitting here wondering how I can eventually get off it... even if the idea of stopping scares me a bit. Honestly, if you really do have LGL, it shouldn't be a huge deal. You'll probably just need to check in with your doctor more often and maybe take it a little easier on yourself physically. At the end of the day, you'll just have to see what your doctor says. Let me know what they tell you!

I asked my doctor if this could be linked to my thyroid, but he shot that down pretty quickly. His take? The thyroid is likely just acting as an amplifier for a syndrome that’s probably been there since birth—assuming it's actually present, of course. First step is getting scheduled for a Holter monitor. I'm really crossing my fingers that I won't end up needing any kind of medication. I'll keep you guys posted once the results come in!

What would this mean:

60 individual premature ventricular contractions recorded on a 24-hour Holter monitor???

Kimberly Scott95 said:What would that mean?

So, I saw this note on a 24-hour Holter monitor: 60 individual premature ventricular contractions (PVCs). Honestly? That sounds like a lot when you read it on paper, but in the grand scheme of things, it’s actually pretty minimal. Most doctors aren't even going to blink at that number. It’s just one of those things where the data looks more intimidating than the reality.

VES are basically just ventricular extrasystoles—that "skipped beat" sensation people always talk about. Honestly, if you're clocking around 60 of them in a 24-hour period, it’s nothing to sweat. As long as they aren't hitting in rapid-fire bursts, it's totally harmless. You just live your life and don't give it a second thought.
Look, on the other hand, you’ve got LGL—that's the Lown-Ganong-Levin pathway. It basically acts like a shortcut that bypasses the AV node entirely. Since there’s no natural "pause" or delay like you'd normally get at the AV node, the electrical signals just race through, which leaves you wide open to those sudden bouts of tachycardia (racing heart). Definitely make sure you're keeping an eye on your thyroid levels, too. When those hormones spike, they can trigger tachycardia out of nowhere. I usually suggest beta-blockers like Atenolol to help slow down that conduction speed and get things back to normal.

My hormones are currently bottoming out, so my palpitations shouldn't actually be linked to my thyroid right now. On what basis is an LGL diagnosis even made? My EKG showed a PQ interval of 0.08-0.10 both times, with no delta wave present.

Kimberly Scott95 said:My hormones are basically bottoming out right now :/ so my palpitations shouldn't have anything to do with my thyroid. How exactly do they diagnose LGL?? I've had two EKGs show a PQ of 0.08-0.10, and there's no delta wave.

Exactly. You've got short PR intervals (pre-excitation), a normal QRS (no delta wave), plus bouts of SVT—which pretty much rules out AFib or flutter.

The Holter monitor failed to catch those random bouts of tachycardia I get out of nowhere. Still, I’m guessing the whole thing isn't anything life-threatening—just incredibly annoying...

Kimberly Scott95 said:The Holter monitor didn't catch any of those random bouts of tachycardia I get out of nowhere. Still, I guess it's probably nothing major, just super annoying...

Exactly...👍

You’ll be outliving me at this rate!🙂