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Is NAC a miracle supplement?

Started by Brenda Parker5 · · 👁 5 views · 163 replies

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Participants Brenda Parker5dustyseal5James Martin4Nicholas Davis4Nicholas MyersZachary Johnson3Sandra Reedanalogmarlin4Jeremy Bishop35Tyler Roberts25mistyscout34Brandon Newman95wanderingbadger0Aaron Jones87dustypilot11Aaron Peterson65cosmiclynx79Mark RobinsonMichelle Lopez86hiddennomad34Megan Rodriguez78
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#1 ·
So, let's talk about NAC—it’s basically just a stable version of the non-essential amino acid cysteine. It works as a stabilizer when it comes to building protein structures, and more importantly, it helps produce glutathione, which is widely known as a powerhouse for fighting off free radicals. One thing I really appreciate is that this stuff is totally plant-based with no animal products involved, so it's perfect if you're following a vegan diet. Plus, it's non-GMO too—just clean, straightforward stuff.

So, here's the deal with cysteine—it's basically a foundational amino acid that builds the proteins our bodies actually need to function. When you take it as a supplement, you're usually looking at N-acetylcysteine (NAC), which the body processes into cysteine and then turns into glutathione—that's a heavy-hitting antioxidant. I've found that NAC is pretty solid for helping prevent side effects when you're on certain medications or dealing with exposure to nasty toxins. Plus, it's great for thinning out mucus, which is a lifesaver if you're struggling with respiratory issues.

So, let’s talk about NAC—it’s basically the acetylated version of the amino acid cysteine. Cysteine and cystine are super closely linked and usually just treated as one single amino acid, but NAC is a much more stable way to get that goodness into your system. Beyond just being vital for protein synthesis, NAC plays a massive role because it's a key building block for glutathione. We're talking about the heavyweight champion of antioxidants here—the strongest stuff our bodies produce. Every single cell in your body relies on it, and it’s absolutely essential for keeping your immune system from falling apart. When your glutathione levels tank, you start seeing connections to all sorts of health issues—specifically liver disease and respiratory infections or those nasty colds. In fact, a deficiency in this specific amino acid is often what kicks off chronic obstructive pulmonary disease (COPD). Honestly, when people pass away, it almost always comes down to those glutathione levels bottoming out—basically when the liver just can't keep up with the synthesis anymore.

Taking NAC as a supplement really helps bump up your body's natural glutathione levels—especially when you're bouncing back from being sick or dealing with heavy physical training.

NAC actually helps shield you from all that toxic stuff—you know, things like acetaminophen, carbon tetrachloride, ethanol, carbon monoxide, chemo drugs, or even just nasty air pollution... It basically acts like a buffer against all those chemical hits.

NAC is a total game-changer when it comes to boosting your physical strength and overall stamina—it really helps you push harder. Plus, it works to bring down those homocysteine levels, which is huge because having too much of that amino acid is linked to heart disease, strokes, and even cancer. It also helps lower your LDL cholesterol, too. Just a solid way to keep things running smoothly.

So, turns out NAC might actually help with blood pressure—basically because it helps relax your blood vessels. Just some food for thought.

I usually just take one to three capsules whenever I feel like it—just toss them back after a meal along with some Vitamin C.

The best way to handle this is to take it five days straight and then give it a two-day break. Here’s the deal—NAC works by boosting your glutathione levels. But if you keep those levels chronically high, your body might try to compensate by dialing back its own production just to maintain homeostasis. Basically, it's trying to stay balanced. So, you really should step away from it at least two days a week to make sure your system doesn't get lazy and stop producing its own natural glutathione.

NAC has been the go-to antidote for acetaminophen overdoses for ages—pretty much a lifesaver in ERs across the country—and it’s also a staple in various cancer treatments. It does a lot of heavy lifting when it comes to heavy metal poisoning, fighting off infections, and even speeding up wound healing. Plus, it plays a huge role in HIV therapy. But honestly, where things get really interesting is in psychiatry. Because it messes with your brain's glutathione and dopamine levels, it's being used to tackle neurological issues like schizophrenia, Alzheimer's, addiction, and depression. It’s just a powerhouse antioxidant with serious neuroprotective properties.


The only real catch when you start this is if you’ve still got those old amalgam fillings in your mouth—if there's any mercury left in there, this stuff is basically going to pull it right out!

Proven benefits:
image


I just caught this video and honestly—it’s worth a look if you're digging into the science behind neuroprotection. It touches on some pretty heavy stuff regarding how we can actually support brain health before things start sliding downhill. The core idea here—and I really believe this—is that we need to be way more proactive about managing oxidative stress. We aren't just talking about getting old; we're talking about the actual cellular mechanics that lead to things like Alzheimer's. There's a lot of talk lately about using NAC to help mitigate some of that damage, and looking at the data, it's hard not to be optimistic about where this is headed. It's one of those topics where you realize the "standard" approach might be missing a huge piece of the puzzle. We rely so much on reactive medicine, but the real game-changer is going to be preventative, targeted supplementation and lifestyle shifts. Just my two cents, but the science is definitely pointing us toward a different kind of toolkit for mental longevity.

This is a staple in my daily routine—I take it five days a week, and I find it works best if I kick things off on a Monday.

Look, if you want to get the most out of your amino acids, you really should take them on an empty stomach—that’s just how you get the best absorption. But hey, if your stomach starts acting up or feels weird about it, don't sweat it—just grab a light breakfast first and take them after that instead. It's all about what works for your body.

Honestly, you're better off grabbing an NAC supplement that already includes the key cofactors—think selenium and molybdenum—to help speed up the conversion into glutathione.
It also works way better when you pair it with ALA—alpha lipoic acid. It’s basically a synergistic powerhouse.

If you're looking for a specific brand, I'd go with Best. You can find it on sites like Vitamin Shoppe, though it's usually a lot cheaper if you just grab it from iHerb instead.

Here is my daily stack—this is what I take alongside my regular therapy to help with detoxing, fighting inflammation, boosting energy, and keeping my cognitive and mental health on point. Plus, it really helps dial down those neurological sensations and just supports overall wellness.
https://postimg.cc/gallery/KG2ZsTT
dustyseal5 dustyseal5 Newcomer
2 messages
joined Mar 2022
#2 ·
I was just about to pull the trigger on an order when I stumbled upon another thread saying you shouldn't take this if you have amalgam fillings. I’m still sitting on about six of them—ancient stuff, probably twenty years old if not more. 🙂
About two years ago, I ended up having one replaced by force, and honestly, I can only imagine what kind of junk leaked into my system during that process. The real issue is that I have a massive phobia of dentists; even with local anesthesia, I can't stand that kind of pain. I'm not even sure if it makes sense to start replacing them all given how many I have left.
I might be getting a bit off track here, apologies, but that part about "if they're still alive"... how do you actually tell? (I might sound totally clueless here 😬).
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#3 ·
dustyseal5 said:I was just about to order some when I stumbled onto another thread saying it’s not recommended if you have amalgam fillings. I still have about six of them—they're ancient, probably twenty years old or more. 🙂
I ended up replacing one two years ago by necessity, and man, I can only imagine what kind of stuff leaked into my system. The thing is, I have a massive fear of the dentist; I can't handle that kind of pain even with anesthesia. I'm honestly not even sure if it's smart to go through with replacing all of them since I have so many.
I drifted a bit off-topic here, sorry—but that part about "if they're still alive"... how do you even know that? (I might sound totally clueless right now 😬).

Hey. I had five. I remember back when I was around 15, a molar cracked—basically the filling gave out—and I had this constant, gross metallic taste in my mouth. From then on, I started getting these symptoms, but whatever, I was terrified of the dentist so I just ignored it. Plus, around here, dentists and GPs just brush off how toxic amalgam is, even though it's actually 54% mercury despite how they manipulate the data to say it's only 50%.
Amalgam is just cheap, toxic junk, and that's why we see so many autoimmune issues and psychiatric conditions today.
It's a harsh reality that people in places like Scandinavia seem to recognize, but over here, they just sweep it under the rug.

Yeah, it's true—when you're replacing them, there's a spike in evaporation, so if someone isn't careful, they're definitely going to get poisoned.

I went to a private clinic and did the replacement in two sessions. It wasn't done by some specialized holistic dentist with full protection gear, just a regular guy. Even she mentioned it would be a good idea to take selenium for about a week.
So, I started taking NAC with selenium, some Dr.'s Best mobile multivitamins, and an Adam multivitamin from NOW, which has other key antioxidants like alpha-lipoic acid and CoQ10.
Before doing any of this, I did a deep dive on Reddit and found tons of similar cases and experiences.
I practically took a huge risk because my symptoms were absolutely destroying me, but a month later, I'm finally starting to feel better.

It's wild that not a single neurologist or immunologist even suspected this, even though the symptoms are textbook.

Right after my last session, I took my first dose of NAC and that multivitamin, and within half an hour, I was peeing for maybe five minutes straight—and it smelled so bad, like a literal sauna. Like, wtf...
James Martin4 James Martin4 Member
24 messages
joined Jul 2012
#4 ·
Viktor Vaughn said:I’ve been reading up on NAC. It looks like it helps people dealing with psoriasis. My wife has been struggling with low Vitamin D lately, and her psoriasis has really flared up over the last few months, so I think I'll give NAC a shot.

NAC is actually great for skin, so I'd say definitely go for it. It’s useful for so many things—it might be the #1 supplement I'd suggest to anyone. Maybe #2 would be Ashwagandha.
Nicholas Davis4 Nicholas Davis4 Active Member
106 messages
joined Mar 2023
#5 ·
Jacob Lopez51 said:Here is basically everything I know regarding autoimmune diseases, neurology, psychiatry, and more. I hope this helps someone out.

Please don't send me links to retail stores; if you're quoting a scientific study, provide the link to the actual paper.
Marketing doesn't really interest me.

Where did you dig up that quote you sent me in my DMs? If it's useful, feel free to post it in the SLE thread so everyone dealing with lupus can see it—it shouldn't be a secret, right? From what I can tell by that snippet, it looks like an animal study, which isn't the same thing as results in humans.
Secondly, I'm not just going to take anything blindly; I have no intention of taking something that boosts the immune system and potentially does more harm than good.

By the way, what is your actual diagnosis?

I'm responding here since you aren't replying to the main thread, and I'm not quite sure why me you're sending this privately—if you think it matters for people with lupus, please share it publicly. Unless, of course, there's a business incentive involved.
It seems to me you're promoting this as a mass solution for everyone.

Sorry for hijacking the thread a bit.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#6 ·
Brenda Alvarez24 said:Don't just send me links to stores; if you're quoting a scientific study, link to the actual study.
Marketing fluff doesn't mean anything to me.

Where did you even dig up that quote you sent me in my DMs? — honestly, if it’s actually useful, just post it here in the SLE thread so everyone dealing with lupus can see it—it shouldn't be a secret, right? — I don't know, but from the little bit of text I'm seeing, it looks like an animal study. That is definitely not the same thing as results in humans.
Also, I’m not just grabbing every supplement out there—I have zero interest in taking something that boosts the immune system when I really don't want to cause more harm to myself.

By the way, what’s your actual diagnosis, anyway?

I'm replying to you here because you aren't engaging in the main thread, and I don't really get why me specifically you're sending this stuff to — if you think this matters for people with lupus, then put it out there publicly. Unless, of course, you've got some kind of business interest in this.
I do notice, though, that you seem to be pushing this for everyone and everything.

Sorry for hijacking the thread a bit.

Lmao, seriously, people are such idiots sometimes—when you're genuinely trying to help someone, they just bite your head off.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411859/

https://clinicaltrials.gov/ct2/show/NCT00775476

PubMed/ClinicalTrials.gov
This pilot study suggests that NAC safely improves lupus disease activity by blocking mTOR in T lymphocytes.

https://www.reddit.com/r/lupus/comme...at_nac_safely/

Look, if something works for millions of people out there dealing with autoimmune, neurological, or psychiatric issues, it's worth noting. I've been following all this for 20 years—back five years ago, Reddit already knew MS was linked to EBV and heavy metals.
If I were making even 5% from a company like NOW Foods, I'd probably be a millionaire by now since they're a top 5 player in the supplement industry. Man, that wouldn't be a bad life.

My own diagnosis: chronic anxiety with fibromyalgia symptoms, some inconclusive brain lesions, and benign fasciculation syndrome. Ever since I added 1 gram of NAC to my regimen alongside my regular meds, I feel like a totally different person—like my entire body and brain were replaced. A total game-changer.

I posted this in the MS and fibromyalgia threads, and to you (since you only post about lupus), but there are studies and thousands of positive comments for all three conditions regarding use for these specific issues.
https://postlmg.cc/mPmNBkJR
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#7 ·
Check out this NAC study for SLE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411859
https://clinicaltrials.gov/ct2/show/NCT00775476

PubMed/ClinicalTrials.gov
This pilot study suggests that NAC safely improves SLE disease activity by blocking mTOR in T lymphocytes.

regarding MS
https://www.frontiersin.org/articles...020.00088/full
https://clinicaltrials.gov/ct2/show/NCT05122559

https://multiplesclerosisnewstoday.c...study-reports/

“The current study using FDG PET imaging suggests that NAC might positively impact cerebral glucose metabolism in MS patients, and this appears to be associated with improved symptoms related to cognition and attention,” the researchers said.

clinical study description

“This study is an important step in understanding how NAC might work as a potentially new avenue for managing multiple sclerosis patients,” said Daniel Monti, MD, director of the Marcus Institute of Integrative Health at Thomas Jefferson University, and the study’s first author.

“The NAC appears to enable neurons to recover some of their metabolic function,” Monti concluded.

image

image
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#8 ·
Brenda Alvarez24 said:Where did you pull that quote from that you sent me in a DM? Honestly, feel free to post that in the SLE thread so everyone dealing with lupus can see it—it shouldn't be a secret, right?

No. I am asking politely that discussions regarding this supplement stay EXCLUSIVELY within this thread, rather than bleeding into every single discussion on the Health board!

Once and if this supplement actually makes it into the official treatment guidelines for lupus, MS, or other conditions, then we can talk about it in those threads. Until then—unless we are discussing managing a productive cough or acetaminophen toxicity—keep the conversation about this specific supplement right here.

Thanks.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#9 ·
Let’s be real—it’s never going to happen. Big Pharma would lose like 80% of their drug market if they actually fixed things. It's a massive business, especially when you look at psychopharmacology.

The World Health Organization is basically predicting that depression will be the number one illness by 2030—so naturally, the lobbyists are dumping billions into antidepressants because they see a massive payday coming... instead of actually treating the root causes, they're just getting rich off everyone else's misery.

medical review article

medical review article: this article reviews the current evidence for the promising use of N-acetylcysteine in the treatment of psychiatric disorders. N-acetylcysteine shows potential to be able to modulate several neurological pathways, including glutamate dysregulation, oxidative stress and inflammation to bring about relief from the troubling symptoms of addictions and substance abuse disorders, schizophrenia, obsessive-compulsive and related disorders, and mood disorders.

Since it’s got an amazing safety profile and it's super easy to get and cheap, N-acetylcysteine might actually turn out to be a game-changer for tackling the mental health epidemic hitting the US right now. scientific conclusion.
Zachary Johnson3 Zachary Johnson3 Newcomer
3 messages
joined Mar 2022
#10 ·
I picked up some NAC from Now, specifically the 600mg ones. Is that the right stuff? It says to take one pill twice a day.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#11 ·
Zachary Johnson3 said:I picked up some NAC from NOW, but they're the 600mg ones—is that right? It says to take one pill twice a day.

Does that version have selenium in it? Personally, I stick strictly to the 1 gram NAC tablets from NOW.
The only real issue I see with those mixes is that you might end up overdoing it on the selenium if you take them long-term—even though they say up to 75mcg a day is safe.
Just take it on an empty stomach in the morning, then wait about 2-3 hours after lunch. Or, if you prefer, just take two at once in the morning.

Pairing NAC with whey protein and glycine works wonders—though honestly, getting glycine through magnesium glycinate is usually a better deal.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#12 ·
Alright, look. I might have had some form of SFN myself, but for sure it was anxiety mixed with symptoms of fibromyalgia and BFS.

The stuff that actually helps—like, seriously puts me into remission—are these supplements and nootropics I take alongside my pregabalin.

1. Benfotiamine 300mg
2. R-ALA 100mg
3. ALCAR 1g
4. TAURINE 3g
5. Magnesium glycine 200mg before bed along with 200mg L-theanine (Suntheanine).

Just a heads up—if you have amalgam fillings, using R-ALA isn't exactly recommended. If that's the case, swap it out for NAC instead.

There's a link between SFN and thiamine deficiency or elevated glutamate levels—maybe even heavy metal toxicity too.

*Supposedly Lion's Mane is also a total miracle for neurological symptoms like this. I can't say much since I just ordered some yesterday, but watch out—only about two brands actually sell the real medicinal Lion's Mane with beta-glucans, so be careful where you shop.
Sandra Reed Sandra Reed Newcomer
5 messages
joined Oct 2020
#13 ·
So, when I'm taking NAC—what else should I be pairing it with (besides Vitamin C) if I want my body to actually make the most of it?
And does it matter if I take it on an empty stomach or right after eating? I guess because the advice online is all over the place... just totally inconsistent.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#14 ·
Gregory Evans said:When taking NAC—what else should I be adding to the mix (besides Vitamin C) to make sure my body actually uses it effectively?
Should I take it on an empty stomach or after eating? I'm seeing totally different advice all over the internet.

Glycine. You can grab the powder version super cheap.
A good multi with active B-complex and selenium too.

And OptiZinc (basically zinc with a little bit of copper mixed in).
Sandra Reed Sandra Reed Newcomer
5 messages
joined Oct 2020
#15 ·
thanks for the heads up!
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#16 ·
I’m gonna take this chance to talk about some other supplements and nootropics besides just NAC.

Honestly, what myo-inositol has been doing for me lately is basically the best drug ever—hands down. I’ve been taking 2x2.5g in powder form, morning and night, alongside my pregabalin.
It just quiets the nervous system so much that almost all my symptoms either drop off significantly or vanish entirely.
I deal with this weird small fiber neuropathy thing, and the only things that actually touch it are stuff for insulin resistance and antihistamines.

Then there's alpha lipoic acid paired with benfotiamine (I just grab those 90-count combo bottles where they’re already mixed together).
I have a confirmed B1 deficiency. One of the big red flags for low B1 is that tingling sensation in your head—though that can also be caused by carnitine deficiency.
These three components—inositol, thiamine, and carnitine—are absolutely vital for how neurotransmitters communicate with your nerves.
If something goes sideways there... you're fucked.

Also, myo-inositol is an incredible remedy for OCD. A lot of people stack myo-inositol with NAC, and it’s widely considered one of the best therapies out there for OCD. For me personally, it also completely kills my anxiety.

MYO-INOSITOL IS HUGE!!
TOTAL GAME CHANGER!

I probably spent hundreds of hours scouring Reddit just trying to find a solution for that one critical situation I was in.
It was pretty straightforward—I searched by symptom to see what might work, and honestly, hearing from people who have fought similar battles for years is the most valuable thing you can find. People out there generally have more resources to stay informed and run deep research. I even consulted with a neurologist from the Mayo Clinic, and after keeping track of everything, I started picking up supplements one by one. Things started getting drastically better, whereas I had totally plateaued while stuck on just pregabalin and Zoloft.

Thank God, because I managed to successfully taper off that Zoloft garbage without any fallout.
Pregabalin is a different beast entirely; even though it masks symptoms, it works on the CNS by blocking excess calcium influx. There’s a massive difference between treating the actual cause of pain versus just messing with the perception of pain—something most neurologists here in the States don't seem to grasp, with a few exceptions.

At one point, I was popping something like 35 pills a day.
Probably the most intense stack I ever ran was 150mg of pregabalin combined with 500mg of rhodiola and 1g of lion's mane.

Another killer combo was pregabalin with lithium orotate and NAC.

NAC is still at the top of my list; for me, pairing NAC with extra glutamate is basically my foundation.

I could probably write a ton more, but I'll leave it at that depending on what you guys want to hear. Catch ya later.
analogmarlin4 analogmarlin4 Member
18 messages
joined Dec 2021
#17 ·
@Mathematicar mentioned that he didn't notice any real changes from taking NAC. It really seems like it’s a case-by-case thing, depending on the individual and how long you actually stick with the supplement. It’s definitely not some kind of magic bullet for everyone.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#18 ·
analogmarlin4 said:@Mathematicar mentioned that NAC didn't really move the needle for him in terms of visible changes. So yeah, it’s totally one of those things where it depends on the individual and how long you're actually sticking with the pills. It’s definitely not some magic bullet for everyone.

Honestly, it all comes down to the dosage. I take one 1g tablet—but the catch is I'm also on two other prescription meds, so it's pretty tough to pinpoint exactly which one is doing the heavy lifting.
There are basically three variables at play here.
Pod 1. pregabalin worked the best and just completely overpowered the other two
Pod2. cymbalta either did a little bit or nothing at all
Pod3. NAC was working in synergy with the pregabalin to absolutely kill it

If he stops taking the NAC and things start sliding backward even a little, then he'll know exactly what the deal is.

To be real with you, when I take NAC, my brain goes from being totally hyper to just... chill. It feels like there's a literal breeze inside my head—I swear, at a 1g dose, NAC has this unique way of triggering dopamine.
Looking at the big picture, NAC provides multiple benefits acting as an antioxidant, a dopamine antagonist, and an anti-glutamate. Realistically speaking, it's an incredibly powerful tool in your arsenal.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#19 ·
A quick look at my collection.

https://postimg.cc/gallery/q6MmzMz

I’ve mentioned this before, but I keep lithium tucked away as my absolute heavy hitter—my ultimate fallback. It's easy to forget that a huge chunk of depression cases actually stem from deficiencies in inositol and lithium levels in the brain.

My go-to stack would be pregabalin mixed with myo-inositol, then an hour later hitting the lithium and NAC together—followed by ALA, benfo, and sublingual methyl B12 about an hour after that.

If things happen to spiral even a little bit out of control, I'm switching exclusively to this.

Look, realistically speaking, lithium is the best tool we have because it touches basically every neurotransmitter and provides neuroprotection. Lithium and inositol? That’s basically an elixir for the brain.

The only real headache with LO is that it dumps way too much dopamine, so you have to pull an immediate counterattack with some NAC.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#20 ·


This channel is wild—honestly pretty scary:

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