Prochymal: Diabetes, Chron, and heart attacks

Greetings to everyone... 👋

I’ve been living with diabetes for four years now. At thirty-one, I'm still relatively early in this journey, but lately, I've become fixated on a report I saw on CNN last week. They were discussing a breakthrough called Prochymal... an actual cure for Type 1 diabetes being developed in the USA. 👍Chronov diseases and cardiac muscle recovery following an infarct—all three share the same purpose... which should arrive here in America within a year... 👋 Wonderful...

The drug is derived from adult bone marrow stem cells—not human embryos. It’s currently moving through the FDA's accelerated approval process to ensure it hits widespread clinical use... soon.
I’ve been skimming some American forums lately... Apparently, patients dealing with Chronov disease undergo Prochymal therapy in two or three stages... They claim to feel incredible after that...
I read somewhere that the medication would be administered intravenously through one or two sessions... with each treatment costing around $150... $0.00 😢 ).
To avoid any amateurish misinterpretations, I am linking an article written by our doctor, who was actually involved in developing this medication... The economy is circling the drain. It’s hard to ignore the cracks forming in the foundation... Recent reports suggest the job market is looking increasingly grim. We are seeing signs of deep instability within the financial sectors, much like what we witnessed during previous downturns. The government's response seems sluggish at best. There is a growing sense that the regulatory frameworks are failing to catch up with the reality on the ground. It feels like everyone is just waiting for the other shoe to drop... Expectations remain low, and frankly, they should be. The numbers don't lie, even if the politicians try to spin them. Just another cycle of uncertainty...

If you have any insights, theories, or whatever else... please share them with us. Though I highly doubt anyone here has actually been treated with this drug... thx. 🙂

This sounds incredibly interesting, and I actually ended up asking about this earlier over in the thread regarding Chronov disease, so I’m really glad you decided to start a dedicated topic for it. I guess I'm hoping maybe someone with a bit more expertise in this field might jump in and write a more detailed breakdown of what's going on. I was wondering where you found that pricing information, though? It seems pretty steep to me, but I suppose it's encouraging to know they're actually working on it, so perhaps the cost might eventually come down enough to make it accessible for people who might struggle to afford something like this right now.

Here is the link containing the article and the specific amount mentioned

If you listen to what the newspapers have been reporting lately, you’d think we were all about to become immune to even the slightest common cold. 😍 Honestly, I think they might have gotten a little ahead of themselves with all that optimism and those bold forecasts. According to the latest updates from Osiris Therapeutics, we are still looking at Phase II or perhaps even Phase III clinical trials, which suggests it will be quite some time before this treatment actually hits the market. That announcement claiming it would be available here in the States by next year clearly refers to one of the ongoing phases of clinical trials. In the meantime, I’d say there’s no harm in staying vaccinated, sticking to a decent diet, keeping active, and taking the dog for walks—especially since, with today's insulin and antidiabetic options, one can lead a pretty wonderful, high-quality life without any major setbacks.

So, I was reading this massive feature in the Democratic Party's main publication yesterday regarding this medication. It was easily five or six pages long, and I have to say, the tone was incredibly optimistic. On one hand, it’s really encouraging, though I suppose the main catch is that we are still quite a long way from seeing it actually become a reality. Toward the end of the piece, it mentioned—I can't quite recall the specific source—that they estimate the drug might enter large-scale production here in the USA within a year, and then maybe another six months after that before it even reaches our local clinics, so I guess there is still plenty of time to wait. The big question mark remains how those upcoming studies will pan out, specifically that third phase involving such a huge number of patients. But, if there is a silver lining, it’s that the article featured a ton of American specialists from all sorts of different fields. Honestly, whether it was diabetes, Chron, or just general medicine, every expert I read about seemed extremely positive about the drug's potential. Even Rajko Ostojić spoke up regarding Chron. So, yeah, that's pretty much it.

I went ahead and read through everything on the Osiris Therapeutics site that bluerider2 linked to earlier. Regarding the Chron treatment specifically—which is what I'm really looking into—it’s currently only been tested on about ten patients, but they've seen some pretty significant progress after just two rounds of therapy, which seems quite promising. From what I can gather, it's moving into phase three of the clinical trials right now, and they're actually accepting applications for people who want to participate in the study. This initial testing period lasted about 28 weeks, and even within that relatively short window of monitoring the patients, the results were impressive. They measure the stage of Chron using certain indices, and according to those metrics, the outcomes have been very strong. So, we're seeing real improvement in a very short amount of time. Now that they're entering phase three, they'll be expanding to a much larger group of patients across multiple different centers over a longer duration. That's when we'll really see how the body reacts; I guess there's always a chance some nasty side effects might show up, though none have been reported so far. I also happened to see somewhere that their stock price has taken quite a jump, so here is the chart...

http://www.nasdaq.com/asp/quotes_rep...&selected=OSIR

As you can tell, Wall Street definitely recognized these positive research results. Since mid-October 2008, the stock has climbed from $11 to $21 per share. It's worth keeping in mind the kind of recession the world was dealing with back then, too. Sometimes, a move like this can be quite telling. 🙂

jadedriver0 said:Hey everyone 👋

I’ve been living with diabetes for about four years now. I'm 31, so I'm relatively new to this. I caught a news segment on CNN last week that really grabbed my attention. Apparently, they've developed a drug called Prochymal in the US that's designed to actually CURE type 1 diabetes 👍, Crohn's disease, and even help repair heart muscle after a heart attack. It sounds like it might reach us here within a year 👋 which would be incredible.

The drug uses stem cells from an adult's bone marrow (not embryos), and it's currently going through the FDA's accelerated approval process to get it into widespread use.
I've been browsing some American forums, and from what I can gather, people with Crohn's are undergoing Prochymal therapy in two or three stages and feeling pretty great.
From what I read, the treatment involves one or two IV sessions, with each session costing around 150 $0.00 😢.
To avoid me just misinterpreting things, I'll drop a link to an article by a doctor who actually worked on developing this drug http://http://www.vjesnik.com/html/2009/01/20/ClanakTx.asp?r=tem&c=1

If anyone knows anything or has any thoughts—though I doubt anyone here has actually taken it yet—please share. Thanks. 🙂

Hi there. I'm the mother of an 8-year-old who unfortunately was diagnosed with diabetes 2.5 years ago. Like you, this news about Prochymal has completely shaken me up and given me hope for a cure. I didn't expect the price to be reasonable, but when you're in this situation, money is the last thing on your mind. Honestly, seeing how fast medicine is advancing, this feels like it could revolutionize how we treat chronic illnesses. I'm rooting for both you and my son to finally get off insulin soon.

I heard some buzz about Prochymal potentially making its way to the States in about a year or so! It really got me thinking—is anyone out there actually treating Crohn's with stem cell-based therapies? If you’ve gone down that road, I would absolutely love to hear your story. Please, please let me know how it worked for you!

Elizabeth Nguyen79 said:I heard some talk about Prochymal potentially becoming available here in the States in about eighteen months or so, so I was wondering if anyone currently undergoing treatment with Chron for stem cell-based therapies might be willing to share their experience? If you're up for it, I'd love to hear how it actually worked out for you.

I just sent you a private message