Peter White80 said:Good day, everyone.
I had blood drawn to analyze my MHC system because I've been dealing with a persistent low-grade fever since May 2020. My temperature regularly hits 99.5°F. I'm also dealing with heat sensations and sweating. Vitamin D levels are between 16-18. TSH is normal.
Here are the results: (the numbers are listed in two sets, separated by a vertical bar)
HLA-A*
02 | - (possible homozygosity)
HLA-B*
08 | 41
HLA-C*
NT | NT (not typed)
HLA-DRB1*
03 | 11
HLA-DqB1*
02 | 03
I would be very grateful if someone could look over these results!
Best regards!
Sir,
I hope you have already undergone a thorough medical evaluation. This shouldn't be one of the first complex lab tests performed, because based on your clinical history, this HLA typing won't provide the clarity you might expect.
I won't delve into the specifics of why through an online forum.
From the HLA typing, we can see a genetic predisposition toward systemic autoimmune diseases. Specifically, there is an increased risk for systemic lupus erythematosus (primarily HLA-DRB1*03, which increases the risk by two to three times compared to the general population), juvenile dermatomyositis (you also carry HLA-B8, which is more prevalent in patients with inflammatory muscle diseases within overlap syndromes), and unfortunately, HLA-DRB1*03 could also signal an elevated risk for juvenile systemic scleroderma (further complicated by your HLA-DRB1*11, which is linked to systemic scleroderma risk), as well as a higher risk for Sjogren's Syndrome. Additionally, HLA-DRB1*03 is associated with a slightly increased risk for multiple sclerosis, though the margin is quite small.
You are just short of the threshold for an extremely high risk of systemic lupus erythematosus. If you possessed the HLA typing combination of A1-B8-DR3 (whereas you have A2-B8-DR3), your lifetime risk of developing that disease would be ten times higher, which would also significantly spike the risk for other systemic autoimmune conditions.
Furthermore, you have an increased genetic predisposition for autoimmune thyroid diseases, Type 1 diabetes, and celiac disease (with the caveat that the typing was not performed with enough "granularity").
None of these conditions are a certainty; you may never develop any of them. We are strictly discussing predispositions.
I should also note that my entire response is qualified by the fact that the typing wasn't done with enough detail—specifically at a four-digit resolution. In your case, it was done at a two-digit resolution, often referred to as low-resolution typing.
I hope my opening sentence makes sense: this specific test creates more questions than answers, and it certainly shouldn't be used as the starting point for evaluating a patient with vague symptoms.
Good luck.