Alex Davis2 said:Hi,
This concerns my son. He’s 13 months old and is fully caught up on all his vaccinations. He hasn't been sick or run a fever until now. He was born three days early and spent a few days under blue light therapy for jaundice and high bilirubin levels. That's really the only complication he's had.
We've done blood work before every vaccine. Out of four sets of results, only one showed neutrophils within the normal range. Two were low, and the most recent one before his MMR shot was the worst—his pediatrician noted the absolute neutrophil count was below 500, which is concerning, even though the child clearly wasn't acting sick. Lymphocytes have always been elevated at 70%, while white blood cell counts stay within range.
A follow-up CBC was recommended.
The worst results looked like this:
WBC 7.1/10*9l. Ref 6-16
Neutrophils 7 % 23-66
Lymph 80 %. 18-60
One month later—in the meantime, he had the MMR vaccine and just had a mild fever of 99.5°F for one day and a rash for one day.
WBC 7.8
Neut 17
Lymph 79
Mono 9
Reference ranges are the same.
Liver function is normal, hemoglobin is 12.5, so the overall blood picture seems fine.
Now we have a blood smear as well. Does that make the neutrophil calculation more reliable?
Lymph 70, neutrof 26, monocytes 4
I want to know if my child actually has neutropenia. Two pediatricians told me to repeat the CBC in a month.
So far, no one has suggested seeing a hematologist.
Is it possible this neutropenia is just transient? Is the child's general well-being enough of an indicator that he's okay and not in danger?
Is there anything else needed for analysis right now?
Thanks.
Hello,
Based on the latest results—WBC 7.8 with a differential via peripheral blood smear showing 26% neutrophils—the calculated absolute neutrophil count is 2028/uL. By that metric, the child would not be considered neutropenic. The previous results you provided, however, do indicate neutropenia.
The most common cause for neutropenia at this age is infection, particularly viral ones, which can impact both production and the depletion of neutrophils. In these instances, the neutropenia is transient and resolves once the infection clears and viremia subsides.
Regarding this specific sample, the evidence points toward an infection (such as a fever or respiratory symptoms) followed by the normalization of neutrophil counts once those signs subside.
However, if the neutropenia persists, other causes must be investigated. I suggest repeating the CBC. Personally, I would retest in two weeks rather than waiting a month. If the repeat test still shows neutropenia, then the blood work should be repeated at least twice a week for six weeks to rule out cyclic neutropenia. At that point, a thorough medical history—including family history—should be taken, a detailed physical exam performed, and the child referred to a pediatric hematologist.
If this isn't transient neutropenia caused by a viral infection, there is a significant possibility it could be benign chronic neutropenia of unknown origin. Usually, no treatment is required unless the child suffers from frequent infections.
In any case, if the next round of testing detects neutropenia, it is time for a full evaluation.
Good luck!