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Is NAC a miracle supplement?

Started by Brenda Parker5 · · 👁 13 views · 163 replies

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Participants Brenda Parker5dustyseal5James Martin4Nicholas Davis4Nicholas MyersZachary Johnson3Sandra Reedanalogmarlin4Jeremy Bishop35Tyler Roberts25mistyscout34Brandon Newman95wanderingbadger0Aaron Jones87dustypilot11Aaron Peterson65cosmiclynx79Mark RobinsonMichelle Lopez86hiddennomad34Megan Rodriguez78
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#121 ·
Ashley Johnson46 said:Jacob Lopez51, how much water are you knocking back with every pill?

And just generally—roughly speaking—how much water do you get through in a day?

I usually take about 8 ounces with each one. Sometimes I'll take a combo of 3 or 4 pills all at once, so that's a bit more.

Total daily intake is right around two and a half liters.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#122 ·
SAMe: Using a natural supplement to take on depression

The actual data on using S-adenosyl-L-methionine (SAM-e) to treat major depressive disorder
https://pubmed.ncbi.nlm.nih.gov/19909689/

https://pubmed.ncbi.nlm.nih.gov/27727432/

https://pubmed.ncbi.nlm.nih.gov/31712971/

https://pubmed.ncbi.nlm.nih.gov/24856557/

https://pubmed.ncbi.nlm.nih.gov/20595412/

https://pubmed.ncbi.nlm.nih.gov/32939220/

A clinician's deep dive into SAMe and its role in neuropsychiatric disorders
https://pubmed.ncbi.nlm.nih.gov/28682528/

Looking at oral SAM-e for primary fibromyalgia—a double-blind clinical study
https://pubmed.ncbi.nlm.nih.gov/1925418/
wanderingbadger0 wanderingbadger0 Member
33 messages
joined Oct 2018
#123 ·
Hey, Jacob Lopez51, did you manage to get any systematic work done toward the end of the summer? I am curious to know how your cortisol levels are looking these days...
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#124 ·
wanderingbadger0 said:Hey, Jacob Lopez51, did you work on your system at the end of summer? How's your cortisol looking these days?

Yeah, I did. My levels were sitting at a crazy 800, but now they're down to 450—which is pretty much back to normal. Cortisol really messes with your thyroid too, but luckily my hormones and antibodies are all good.

The combo of SAM-e and tyrosine in the morning has been a total game changer for me. You’re supposed to take tryptophan before bed to get that serotonin balance right, but I actually take lithium orotate in the afternoon, so I end up with more than enough serotonin from that.

First thing in the morning, I hit the combo: pregabalin along with SAM-e, methylated B12, folate, and some Jarrow Formulas P5-P (those sublingual lemon tablets), plus 750mg of L-tyrosine and 1g of Alcar.

About an hour later, I move on to the next batch—r-lipoic acid, benfotiamine, and lion's mane.

After lunch: 2 magnesium malate tablets, OptiZinc, 3 capsules of flax oil (ran out of my omega, so this works fine), 1 capsule of evening primrose oil, 2000IU of D3, curcumin (with black pepper extract), and quercetin with bromelain.

An hour after that: lithium orotate + NAC + 1g of Vitamin C.

Later in the afternoon: MSM for detoxing.

Early evening: 1g lysine and 500mg monolaurin—for that antiviral boost.

After dinner: pregabalin and L-theanine, then a little later, turmeric tea with a few grams of reishi powder.

One hour before bed: KSM-66 ashwagandha and a few grams of myo-inositol.

So yeah, that's the protocol currently keeping everything in check... about 25 pills and a handful of powders.

How are things with you?
What's your stack looking like??
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#125 ·
Turns out, lithium orotate actually outperforms lithium carbonate when it comes to potency and effectiveness—and it’s way less toxic too—based on a recent mouse study looking at mania models.
https://www.biorxiv.org/content/1.490227v1.full
Brandon Newman95 Brandon Newman95 Active Member
245 messages
joined Jun 2024
#126 ·
So, how are you holding up?
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#127 ·
Kimberly Ward said:So, how are you feeling?

Honestly, pretty great. Ever since I started the SAMe and tyrosine combo—plus some reishi last night—it’s been seriously awesome.👍

I'm thinking about adding tryptophan before bed to help with serotonin and melatonin levels. I'm pretty sure I'm getting enough serotonin from the lithium orotate, but since tryptophan hits both, I want to see how things go when I pair it with ashwagandha and magnesium glycinate right before sleep.
https://www.everywomanover29.com/blo...r-over-a-year/
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#128 ·
https://www.optimallivingdynamics.co...ns-medications

Just a heads up—taking Gabapentin or Pregabalin basically drains your system of folate, biotin, Vit D, B2, B6, and B12. It also wipes out your levels of Vit A, Vit K, calcium, zinc, copper, magnesium, and—this is the big one—l-carnitine.😵
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#129 ·
Reishi is honestly incredible. I mean, black seed oil is great and loaded with benefits too, but for me—personally—nothing hits quite like Reishi. It’s the way it works on my central nervous system that really stands out—it just seems to do wonders for my GABA and serotonin levels.
I’m telling you—it’s wild how much better I sleep when I stack Schillinger with KSM-66 Ashwagandha. It knocks me out cold. Also, if you're dealing with anything EBV-related, Reishi is easily one of the best supplements out there—honestly just as effective as a combo of quercetin and bromelain when you need a solid antihistamine hit.

For over two millennia, Reishi mushrooms—you know, Ganoderma Lucidum—have been held in this incredibly high regard by traditional practitioners in Asia as a powerhouse for healing. It’s basically legendary stuff.

They're used all over the place in traditional Chinese medicine—pretty much as a go-to for treating a huge range of different ailments.

Look, Reishi mushrooms are basically the GOAT of the medicinal plant world—seriously, they're legendary for a reason. They’ve got this unmatched healing power that just hits different, and the best part? You aren't dealing with any of those nasty side effects you get from other stuff. It’s just pure, effective wellness.

Finding Reishi out in the wild is actually pretty tough—like, really tough—so for the longest time, it was basically reserved for royalty and the ultra-wealthy in Asia. It stayed that way until the latter half of the 20th century when organized cultivation finally kicked off over in Japan, which is when this incredible mushroom finally became accessible to everyone else around the globe.

Back in the day, people in ancient China used to treat Reishi mushrooms like they were some kind of royal medicine—basically the go-to for kings and emperors.

Back in the day, Dr. Shi-Jean Lee—who was basically the go-to medical authority for the Ming dynasty—wrote this massive encyclopedia of medicinal herbs called *Bfan Chao Gang Moo*. In it, he made some pretty bold claims about Lingzhi mushrooms (you might know them as Ganoderma Lucidum), recommending them as a serious powerhouse for fighting off all sorts of different ailments.

He honestly pegged Reishi mushrooms as the absolute heavyweight champion of medicinal plants—putting them way ahead of even Ginseng—and here’s why he thought they were in a league of their own:

Look, this mushroom is totally non-toxic—you could honestly eat it every single day and wouldn't have to worry about any weird side effects hitting your system.
When you actually use it the right way—like, properly—it basically just resets your body to its natural baseline. It gets everything back in sync so all your organs can finally just do their jobs without any drama.
Immunomodulators — basically, they just help dial your immune system up or down to keep everything running smooth.

Honestly, if you ask me, the absolute biggest game-changer with Reishi mushrooms is how they kick your immune system into high gear—it’s easily their most powerful potential benefit.

So, Reishi—you know, *Ganoderma lucidum*—is actually packed with organic germanium, polysaccharides, and triterpenes. It’s not just hype, either—those active components are scientifically proven to give your immune system a serious boost.

So, according to traditional Chinese medicine—which, let's be honest, has some pretty deep roots—Ganoderma lucidum is basically a powerhouse for keeping everything running smoothly. It’s used to support the function of five major organs—we're talking the heart, lungs, liver, pancreas, and kidneys. Just a solid way to keep the whole system in check.

So, look—Ganoderma lucidum isn't just some random mushroom you find growing in the woods; it’s actually legit when it comes to supporting your body. We're talking about everything from respiratory and cardiovascular stuff to digestive, neurological, and even endocrine issues. It basically covers a massive range of ways to help keep your system running right.

Look, all these different ailments—and honestly, there are plenty more where those came from—are actually being tackled quite effectively by Ganoderma. It really comes down to its most important trick: that whole "rooting vitality" thing—basically, it just gives your immune system the massive boost it needs to function properly.

Honestly, Ganoderma mushrooms are a total game-changer for keeping your whole system in check—they basically help regulate your entire metabolism and make sure all your organs are actually firing on all cylinders.

So, I’ve been looking into how Ganoderma Lucidum—you know, that Reishi mushroom stuff—actually plays with tumors. It’s honestly pretty wild when you start digging into the science behind it. The basic idea is that these mushrooms aren't just some random health trend; they contain these specific compounds called triterpenoids and polysaccharides. From what I can gather, these things seem to mess with the way cancer cells behave—basically trying to trip them up so they can't grow or spread like they normally would. It’s less about "curing" everything overnight and more about this complex interaction where the mushroom might help kickstart the body's own immune response to target those bad cells. Now, obviously, nobody's saying this replaces actual medical treatment—that would be crazy. But as a supplement to work alongside what doctors are doing? There’s some really interesting research suggesting it could help modulate the immune system and maybe even reduce some of the side effects from harsher treatments. It's definitely worth keeping an eye on as the studies get more serious. Just a thought.

The best way to actually take on something like Ganoderma Lucidum tumors is by dialing in your immune system—specifically by cranking up the body's natural ability to defend itself against the growth.

Most of the heavy lifting when it comes to researching how mushrooms fight off tumors has actually been happening over in Japan.

Back at the MD Anderson Cancer Center, researchers like Ikekawa and his team were already digging into how edible mushroom extracts fight tumors way back in '69—and by '74, Hamuro and Chihara stepped in to build on that foundation with their own joint study at the institute.

So, here’s the bottom line from that study—and honestly, a whole bunch of other research out there too:

So, I was looking into shiitake mushrooms—*Lentinula edodes*, if you want to get all scientific about it—and the data is actually pretty wild. We’re talking an 80.7% reduction rate in tumor growth. Even crazier? In 6 out of 10 cases, the tumors completely backed off. Just gone. It's honestly hard to wrap your head around how much power is packed into something you can just pick up at Whole Foods.

So, I was looking into Coriolus Versicolor—and honestly, the numbers are pretty wild—it shows a tumor braking rate of about 77.5%. Even more impressive? In 4 out of 8 cases, they saw total tumor regression. Just a massive win for that kind of data.

Ganoderma Lucidum (Reishi) — we’re talking about a tumor inhibition rate of 98.5%, where the tumor completely regresses in 4 out of 5 cases (and honestly, with certain components, that inhibition hits 100%, leading to total regression in every single case).

It’s also worth pointing out—and this is huge—that some of these anti-tumor agents don't just tackle primary tumors; they actually help block the appearance and spread of metastases too.

The researchers behind this have pretty much proven that certain medicinal mushrooms show an incredibly high rate of stopping tumor growth—not to mention a significant chance of complete regression if you start using them early enough—plus they provide massive protection if you take them before things even get started.

The healing properties of Reishi mushrooms

1. They’re incredible immune regulators

Studies have shown that Reishi mushrooms are masters at regulating the immune system, basically boosting our body's ability to fight off outside threats.

A 2006 study actually highlighted how these mushrooms act as true immune modulators.

And here's the cool part: they don't just ramp up your immunity; they can actually calm it down too, depending on what your specific body and immune system needs at the moment.

So, for instance, during infections or when inflammation kicks in, Reishi strongly boosts a weakened immune system by strengthening T and B defense cells—but in the case of autoimmune issues, they act as suppressants to dial back an overactive immune response.

It’s basically a form of plant intelligence that these mushrooms possess.

2. They protect against tumors

Beyond just strengthening the immune system to prevent cancer from starting, Reishi mushrooms have a very specific way of fighting this disease.

They contain ganoderic acid, which has the power of apoptosis—that's essentially the selective destruction of cancer cells while leaving healthy ones totally untouched. So, in my view, Reishi mushrooms are more effective and way safer than harsh chemotherapy.

A 2010 study out of Asia showed that ganoderic acid prevents tumor growth and stops it from spreading through the body, aided further by the beta-glucans found in these fungi.

These mushrooms also work wonders with melanoma because they increase the sensitivity of cancer cells to the "killer cells" that already exist naturally in the human body.

3. Heart health and blood sugar balance

The triterpenes found in Reishi mushrooms do more than just improve circulation; they can also help lower blood pressure and prevent clogged arteries or atherosclerosis.

On top of that, these mushrooms help balance blood glucose levels and reduce insulin resistance, making them a solid ally in the fight against diabetes.

4. Neuroprotective effects and Alzheimer's prevention

Because they are packed with antioxidants, Reishi mushrooms reduce oxidative stress and improve cytokine modulation in the brain, providing neuroprotection and preventing brain damage.

A 2012 study indicated that these mushrooms offer protection against both Alzheimer’s and Huntington’s disease.

5. Great for seasonal allergies and asthma

The ganoderic acid in Reishi can actually prevent histamine release, which makes it awesome for dealing with seasonal allergies.

There are even cases where Reishi mushrooms helped people finally shake off those miserable allergy symptoms.

If you're struggling with allergies, I'd recommend taking 1000mg of Reishi daily. Plus, it's a great support for managing asthma issues, too.

6. Massive boost to vitality and lifespan

Based on the research, it's no wonder Reishi is called the “mushroom of immortality.”

Seriously, they can potentially extend a person's lifespan by 7 to 16 years. Their power comes from a wealth of antioxidants that slow down the aging process, while also protecting cellular DNA from the damage that naturally accumulates over time.

Reishi also contains triterpenes, which are great for improving both circulation and mental focus.

7. Improves liver function

Reishi mushrooms promote healthy liver function and speed up the body's ability to flush out toxins and bacteria.

They also help protect that massive, vital organ of yours—keeping liver disease at bay.
https://www.dc-acupuncture.com/physi...antihistamines
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#130 ·
Histamine Intolerance (The Science-Backed Game Plan)
wanderingbadger0 wanderingbadger0 Member
33 messages
joined Oct 2018
#131 ·
Jacob Lopez51 said:I am. It was at 800, but now it's down to 450, which is almost back to a normal range. Cortisol definitely has a significant impact on the thyroid, but fortunately, my thyroid hormones and antibodies look fine...

That is wonderful news.👍 Such an incredible improvement...

How are you doing?
What supplements are you currently taking??

I just saw this. Mentally, I feel slightly better, but physically, I am a complete wreck, so I really need to force myself to get active as soon as possible...

I have gone back on my antidepressants, which have finally started working, so I don't feel the need for what you recommended right now. I might try those if I ever decide to stop the medication again, though I am hesitant to mix everything all at once. NAC didn't seem to help my mental state, so I am a bit skeptical about this other option too. Regardless, I trust that it works for you. Those 25 tablets you take must be doing something, one way or another... 😁

How much do you typically spend per month on all these nootropics and supplements?
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#132 ·
wanderingbadger0 said:Awesome.👍 A massive step forward.

Just seeing this now. Mentally I'm doing a little better—but physically? I'm a total wreck, so I really need to force myself to get moving ASAP.

I'm back on my antidepressants and they're finally actually kicking in, so I don't really need that stuff you recommended right now. I might look into it if I ever decide to quit the meds again—honestly, I'm too nervous to try mixing everything all at once. NAC didn't do much for my headspace, so I'm a bit skeptical about this other thing too. But hey, whatever, if it works for you, it works. I mean, those 25 pills you're taking have got to be doing *something*, whether we like it or not.😁

How much are you dropping every month on all these nootropics and supplements?

Gotcha.
I mostly grab stuff from iHerb when there's a sale, but since I buy enough to last me three months, I'm looking at around $1,200$500 per run.

My PEA (Palmitoylethanolamide) just showed up today.

Everything just depends on what specific issue you're dealing with—once you figure that out, you can build a solid stack.

Try taking 5g of Reishi mushrooms and 5mg of Lithium Orotate... then let me know how your symptoms feel after that... XD

It’s hard for people to wrap their heads around the fact that anxiety and depression aren't "cured" by antidepressants—they basically just mask the issue, if anything.
And honestly, in a few rare cases, you might only need one single supplement or nootropic because there are so many different factors at play.

The real turning point for me was seeing this guy who managed to fix his peripheral neuropathy using nothing but supplements and nootropics after doctors had basically written him off.
Basically, there isn't anything natural that can't be treated with the right supplements. Plus, there's tons of research showing that depression is often just neuroinflammation anyway.

But people really need to educate themselves—not all supplements are created equal, and neither are the brands.

Like, Alpha Lipoic Acid versus R-Lipoic Acid is night and day—or take Turmeric, where you've got BCM-95, Longvida, or C3.

Most B-complexes you see on the shelves are pretty much useless. You want the methylated, active forms—those are the ones your body can actually absorb and use fully.

And so on...
wanderingbadger0 wanderingbadger0 Member
33 messages
joined Oct 2018
#133 ·
Jacob Lopez51 said:It is difficult to accept that anxiety and depression might never truly be cured by antidepressants, as they often merely mask the underlying issues, if they address them at all.

Regrettably, in certain rare instances, a single supplement or nootropic may suffice, given how many different factors are involved in the equation...

I certainly understand that perspective, but I was searching for a rapid solution. I simply didn't have the luxury of time or the financial resources to research which specific combination of supplements or nootropics would be most effective for me.

The turning point for me occurred when I witnessed someone successfully manage peripheral neuropathy using nothing but supplements and nootropics after being dismissed by their doctors.
Essentially, there is nothing that natural supplements cannot address. There is already a vast body of research suggesting that depression is actually just neuroinflammation.

👍

Please continue to share your thoughts and keep us updated on your progress.

One day, I hope to be able to dedicate myself to this study as intensely as you do...
Michelle Lopez86 Michelle Lopez86 Member
10 messages
joined Jun 2016
#134 ·
Jacob Lopez51 said:Right on.
I mostly grab my stuff from iHerb when they have sales, but I usually go quiet for about three months at a time, then I'm back at it spending maybe $1200-$500.

My PEA (Palmitoylethanolamide) just showed up today.

Honestly, it all boils down to what specific issue you're dealing with. Once you actually nail down the root cause, building a solid supplement stack becomes way easier.

Just try taking 5g of Reishi mushrooms and 5mg of lithium orotate... then come back and tell me how your symptoms feel after that.. XD

It’s hard for people to wrap their heads around the fact that antidepressants aren't a "cure" for anxiety or depression—they mostly just mask the underlying issues if anything.
Sadly, in some rare cases, you might only need one single supplement or nootropic because there are so many different variables at play.

The real wake-up call for me was seeing this guy who completely cleared up his peripheral neuropathy using nothing but supplements and nootropics, even after mainstream doctors basically gave up on him.
Bottom line: there isn't much that natural supplements can't help address. Plus, there's a ton of research out there suggesting depression is really just neuroinflammation.

But look, people actually need to educate themselves. Not all supplements are created equal, and neither are the manufacturers.

For example, there is a massive difference between standard alpha lipoic acid and R-lipoic acid. Or take turmeric—you've got BCM-95, Longvida, C3... those are leagues ahead.

And those cheap B-complex vitamins you see everywhere? They're pretty much useless. You want the methylated, active forms so your body can actually absorb and use them properly.

And so on...

One quick side note:
Hey, which specific Reishi powder are you using? There are way too many brands on the market right now..
From what I can see, you can find Reishi tinctures on Etsy or local farmer's markets, but I don't know—which is better for potency, the drops or the powder?
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#135 ·
Brandon Brown29 said:Random question here:
Hey, which specific reishi powder are you using? There are way too many brands out there right now..
From what I can see, there are some local organic farms selling reishi drops online, but honestly, I have no clue—which one actually works better, the liquid drops or the powder?

I've been using this one from a shop in Oregon:
https://alternativa-webshop.com/prod...utrisslim-125g

Honestly, the gold standard is probably Real Mushrooms—either in capsules or even better if you get the powder. Personally, I take Lion's Mane from Real Mushrooms in a capsule every morning, then switch to Reishi powder at night.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#136 ·
image

image

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765232/

In general—studies using animal models show that PEA has all these properties that make it look super promising for treating fibromyalgia or chronic fatigue syndrome (ME/CFS). Basically, PEA stops the release of both existing and newly made mast cell mediators, things like histamine and TNF-alpha. Both PEA and its cousin adelmidrol (which is just a di-amide derivative of azelaic acid) can help dial back those mast cells.

As for anyone dealing with brain fog: one of the biggest wins with PEA is how it hits the glial cells. If those glial cells get overactive, they trigger brain inflammation—it's a mess. PEA helps modulate and calm them down. That’s pretty much why PEA shows up as an effective way to manage autism and fibromyalgia. A lot of folks find that adding PEA to their routine clears the fog and sharpens their thinking.

Just a heads up: it might take about a week before you actually feel anything.

In Europe, PEA is actually available as a prescription med—and some versions are even manufactured in labs over in Rome.
That bolded part right there? That's the real struggle with fibromyalgia.
The holy grail combo for fibro would be: pregabalin + PEA + r-lipoic acid + benfotiamine + ALCAR.

Edit: Look, I've tried just about everything. I intentionally saved PEA for last for a reason. We'll see how it goes in two weeks. I picked up two bottles, and if this works, I'm definitely buying more. If PEA does the trick, it could let me cut back on my pills significantly. My goal is to get down to 10 tablets a day—I'm aiming for that, but I won't rush it until I'm 100% sure of the details. I wanted to experiment with a bunch of stuff so I could stay informed, and honestly, the more I tested, the more I learned. Neuropsychiatry was always the area that interested me the most.
I ran into some people on Reddit who had all these data points and tests, claiming that all of this is basically a joke from a layman's perspective. But hey, I came here to learn, and I've definitely picked up a ton along the way.
hiddennomad34 hiddennomad34 Newcomer
2 messages
joined Jun 2022
#137 ·
Can anyone recommend a NAC supplement? My gastroenterologist told me the one from Now Foods isn't exactly top-tier.
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#138 ·
hiddennomad34 said:Can anyone recommend a good NAC brand? My GI doctor mentioned that the one from Now Foods isn't exactly top-tier based on what they've seen.

https://www.iherb.com/pr/natural-fact...-capsules/2663
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#139 ·
Jacob Lopez51 said:https://www.iherb.com/pr/natural-fact...-capsules/2663

I ran out of mine too—and honestly, you picked a winner right here. Seriously great review, and the bang for your buck on this one is unbeatable.

If you're looking for high-quality turmeric—just like I am—this is definitely the way to go:
https://www.iherb.com/pr/naturewise-o...capsules/77858
Brenda Parker5 Brenda Parker5 Active MemberOP
59 messages
joined Aug 2020
#140 ·
r/covidlonghaulers - Neuro Inflammation / MCAS - New research on combining PEA & Luteolin
A buddy of mine sent over a link for a new protocol—apparently, it’s being used in neuro-rehab departments at major hospitals across the US. The whole thing revolves around pairing PEA (palmitoylethanolamide co-ultramicronized) with LUTEOLIN (a flavonoid).

I’m dealing with a brutal relapse right now—major inflammation hitting my brain, my eyes, and muscle groups all over the place. The pain, the brain fog, that weird feeling of head fullness and pressure... it's pretty rough at the moment (around an 8/10).
I actually started the suggested dosage today. I’m planning to stick with it for 8 weeks, so I'll check back in here if I notice any real improvements or weird side effects.

The Highlights
• When mast cells get activated by oxygen and glucose deprivation (OGD), they dump out these neurotoxic factors.

• Using PEA and luteolin together works synergistically to cut down on the neurotoxicity caused by those OGD-triggered mast cells.

• Basically, PEA and luteolin provide direct, combined neuroprotection to neurons when they're hit with OGD.

Dosage
Sublingual granulated PEA-LUT (700/70 mg), twice a day for 8 weeks.

Research
https://clinicaltrials.gov/ct2/show/NCT05311852

https://www.sciencedirect.com/scienc...06899316304887

https://www.mdpi.com/1422-0067/22/16/8717/htm

https://ichgcp.net/clinical-trials-registry/NCT04489017

Since Luteolin can be kind of hard to track down in the States, you really don't have much choice but to go with Quercetin and Bromelain instead.
Quercetin is pretty much the gold standard for stabilizing mast cells according to a ton of studies (check out this article https://hoffmancentre.com/natural-treatments-for-mcas/)

image

The deal is that Quercetin has an extra oxygen/hydrogen OH group attached.

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