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Lab results - looking for opinions [PLEASE READ 1ST POST]

Started by vividsailor7 · · 👁 239 views · 3.9K replies

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Participants vividsailor7redcrane22Sandra Rivera37swiftbear86melloworca6Dana Martin87ironskipper80mellowgardener15goldenmarlin6analogbison13Nicholas Myersstormygardener34Roger RodriguezDonna Mitchell3Kenneth Vaughn2Laura Ward98briskseal32Susan Vaughn46Zachary Lewis4driftingmason52rustyheron55Laura Chavez47vividstag24lonecanyon8 …
Peter Rogers Peter Rogers Active Member
60 messages
joined Dec 2011
#2881 ·
Maria Fisher46 said:Hey there,

Honestly, I don't have much else to add right now. I’m still seeing those plasma cells popping up in the peripheral blood—which, let's be real, they really shouldn't be there—but thankfully it's just a small amount. I guess this is just going to be the "new normal" for this situation, isn't it? I remember someone asking earlier if it would be worth shelling out for extra private testing. My answer remains a hard no. Don't waste your money. That advice regarding future genetic analysis stays the same, too; we should eventually look into a specific gene panel for ALPS and ALPS-like disorders covering FAS, FASLG, CASP10, NRAS, KRAS, CASP8, PRKCD, and STAT3. It's something to keep on the radar for down the road.

Thanks a million, man. I really appreciate it.
I honestly have no clue how we’re ever going to make getting this kind of genetic testing actually happen in real life. Right now, the doctors just brush it off, telling us that our kid's condition is basically "perfectly normal" for their situation. But let me tell you, as a parent, it is incredibly hard to just sit here and swallow that definition of "normal." How am I supposed to be okay with a version of normal that requires us to constantly hover and watch for the next sudden, unpredictable thing that might go wrong? It’s exhausting, really.
I seem to remember you mentioning that things aren't really an option here in the States for now, but that there might be some actual potential if you look at opportunities abroad.

So, what’s left? At this point, I guess all we can really lean on is that one diagnostic method where you just look at how someone is actually living—you know, checking if they feel happy, vibrant, and full of energy—while completely ignoring that nagging, paranoid fear in the back of our minds that we might be missing something crucial.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#2882 ·
Emily Ortiz27 said:Thank you so much.
I'm at a loss regarding how to actually get a genetic analysis done. For now, we’re being told the child's condition is "obviously normal," but as a parent, it's hard to accept a version of "normal" that requires constant monitoring and a steady stream of unexpected surprises.
I recall you mentioning that these aren't available here in the States yet, though they might be accessible abroad.

All that's left is to trust our eyes—seeing a kid who is happy, lively, and energetic—while trying to ignore the nagging fear that we're missing something vital.

Ma'am,

these tests are purely diagnostic tools; they aren't crystal balls that can predict who will develop a malignant disease or lymphoma, or when it will happen. They should be becoming more widely available through insurance referrals in the US soon, but for the moment, the fallout from the pandemic has slowed everything down and put things on hold.

Unfortunately, with lymphoproliferative disorders, you're left with constant monitoring and living in uncertainty. That becomes part of the "new normal." Right now, there isn't a single test on the market that can answer who will transform into a malignancy within this spectrum of diseases, or when.

What is truly baffling here, however, is the lack of a definitive diagnosis (the immunologist disputes an ALPS diagnosis, while the hematologist is tracking it "as possible ALPS"?!).
Jason Grant85 Jason Grant85 Member
22 messages
joined May 2017
#2883 ·
My TSH is sitting at 4.18, and my Anti TPO came back at 59.96. At these levels, would anyone actually start me on some kind of medication? Thanks a million!
Peter Rogers Peter Rogers Active Member
60 messages
joined Dec 2011
#2884 ·
Maria Fisher46 said:Look, ma'am,

these specific tests are strictly for diagnostic purposes; they aren't some crystal ball that can predict exactly who is going to develop a malignant disease or lymphoma and when. They should be available through standard insurance referrals here in the States pretty soon, but everything's been pushed back and put on hold because of the COVID situation.

Unfortunately, when you're dealing with lymphoproliferative disorders, you're stuck with constant monitoring and living in this state of uncertainty that’s basically becoming part of our "new normal." As of right now, there isn't a single test on the planet that can answer the question of who will undergo a malignant transformation and when, even if they already have a diagnosis within that spectrum of diseases.

But what really trips me up in this specific case is the total lack of a definitive diagnosis—I mean, the immunologist is actively disputing the ALPS diagnosis, while the hematologist is just watching over it like, "well, maybe it's ALPS"? It makes no sense.

The whole thing is just leaving me totally confused...
We went in for the checkup, and honestly, the doctor seemed completely indifferent about the plasma cells in the smear; from the way she was talking, I got the feeling she's just chalking them up to a mistake by the cytologist or pathologist rather than an actual finding.

So, we'll mostly just keep moving forward at the same pace, staying hopeful, and for now, sticking with no changes and no clear diagnosis. If any other questions pop up, I'll feel free to reach out to you guys again, because we always seem to find real answers in this group.
Karen Alvarez40 Karen Alvarez40 Member
11 messages
joined Jul 2018
#2885 ·
Maria Fisher46 said:Basically, since we already covered the thyroid hormone levels and those urine tests you did, my previous advice still stands completely.

I’m more than happy to upload the results from my extra tests if you think that would help.
I was hoping you could take a look at these and give me your thoughts: https://ibb.co/pQVgWH7 and https://ibb.co/DtyS9Wg

Thanks!
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#2886 ·
Emily Ortiz27 said:The whole situation is a bit of a blur...
We had the checkup, but the doctor seemed completely indifferent regarding the plasma cells in the smear. From our conversation, I got the impression she’s chalking them up to a cytologist's error rather than an actual finding.

For now, we’re sticking to the current routine and hoping for the best—no changes and no diagnosis yet. If any questions come up, I’ll feel free to reach out again; this group always provides clarity.

Don't hesitate to reach out. I will also let you know once genetic testing becomes available here in the States.

Karen Alvarez40 said:I am attaching the results from the additional tests per your request
and would appreciate your thoughts: https://ibb.co/pQVgWH7 and https://ibb.co/DtyS9Wg

Thanks.

Ma'am,

Certain deviations in lab work can stem from intense training—essentially signs of muscle injury (elevated creatine kinase, along with slightly high LDH and AST levels). To confirm if this is the case, one would need to cease all exercise for seven days and then re-test CK, LDH, and liver enzymes. If those numbers remain elevated, further investigation in that direction is required.

Some deviations cannot be attributed to physical activity, such as iron-deficiency anemia. That particular finding demands significant attention; a young male athlete generally shouldn't be presenting with sideropenic anemia.

Similarly, elevated GGT activity cannot be linked to exercise.

An internal medicine consultation is necessary. Given everything mentioned, a gastroenterologist should be the first point of contact. They ought to take a detailed history—including specific dietary data—perform an exam, and subsequently decide if there is an indication for endoscopic evaluation of the digestive tract, celiac testing, a follow-up abdominal MRI (given the previously noted hemangioma), and determine the next steps.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#2887 ·
Lisa Perez37 said:My TSH is 4.18, and my Anti TPO is 59.96. Is any kind of treatment typically started at these levels? Thanks so much!

Hi there,

To get a clear picture, we need to see the rest of your thyroid hormone levels beyond just the TSH. We also need to know what symptoms you're experiencing and whether or not you are pregnant.
Jason Grant85 Jason Grant85 Member
22 messages
joined May 2017
#2888 ·
Maria Fisher46 said:Hi there,

you really need to look at the full thyroid hormone panel—not just TSH—and we also need to know what symptoms you're dealing with, plus whether or not you're pregnant.

I'm not pregnant, and I'm 47. Honestly, the list of symptoms is endless. My hair is falling out constantly, and my eyebrows are thinning out too—which hasn't even improved despite using Minoxidil. Then there's this crushing fatigue; even an eight-hour sleep isn't enough—the longest I’ve managed to sleep straight was 14 hours—and I can barely drag myself out of bed in the morning. I try to get everything done before noon because after that, I'm just completely wiped. I've also got these heavy, painful lower legs that sting and tingle sometimes. My skin is dry and flaky, and my eyes feel incredibly dry—which is weird because I've worn contacts for almost 25 years without a single issue until lately. Constipation is becoming more frequent, too. Plus, my periods have become extremely painful and heavy. I'm dealing with swelling, especially around my eyelids, and I've gained 7 kg in a single year—even though I haven't changed my diet and I've actually been pushing myself to stay active whenever the exhaustion allows (mostly cycling, swimming, and walking).
I used to just deal with each of these things individually—I never once connected the dots. But then I started Googling the connection between hormones and melasma (since my face has been darkening despite using SPF 50+) and stumbled upon the symptoms of hypothyroidism. It turns out there's a family history here: both my dad and my sister have Hashimoto and take Euthyrox. My dad also deals with vitiligo and rheumatoid arthritis, which his mother had as well. So, there's definitely a genetic predisposition toward autoimmune issues in our family.
Thanks so much for the response! 🙂
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#2889 ·
Lisa Perez37 said:I’m not pregnant—I'm 47. The symptoms are piling up. Hair loss is severe, and my eyebrows are thinning out just as badly; even Minoxidil hasn't done a thing to stop it. Then there's the exhaustion. It’s heavy. Sleeping eight hours isn't enough; I’ve had stretches where I slept 14 hours straight and still felt wiped. I can barely drag myself out of bed in the morning. If I manage to get anything done before noon, that’s really it for the day. My lower legs feel heavy and painful, with occasional tingling and burning sensations. My skin is dry and flaky. My eyes are incredibly dry, too—I’ve worn contacts for nearly 25 years without an issue, but lately, they're becoming unbearable. Constipation is getting more frequent. On top of that, my periods have become extremely painful and heavy. I’m also dealing with swelling, particularly around my eyelids. To top it all off, I’ve gained 7 pounds in a year despite eating the same things and forcing myself to stay active whenever my energy levels allow—mostly cycling, swimming, and walking.
I used to handle each of these symptoms in isolation. I never once connected the dots. It wasn't until I started Googling the link between hormones and melasma—since my face was reacting wildly to even SPF 50+—that I stumbled upon the symptoms of hypothyroidism. There’s a clear genetic thread here: my father and sister both have Hashimoto and rely on Euthyrox. My dad also deals with vitiligo and rheumatoid arthritis, which ran in his mother's side, too. It's safe to say there is a significant family history of autoimmune issues.
Much appreciated. Thanks for the response. 🙂

To whom it may concern,

You didn't mention the fT4 (T4) levels.

A TSH level of 4.18 mIU/L falls within the standard reference range, according to the guidelines established by the American Thyroid Association back in 2009. There are exceptions, of course. For pregnant women, the targets shift lower—usually down to 2.5 mIU/L or 3.0 mIU/L depending on the trimester. Conversely, for those over 80, some research suggests that levels as high as 7.0 mIU/L might just be a normal physiological adjustment to aging.

It’s worth noting that there is no consensus on what actually constitutes a "normal" TSH level. Back in 1986, for instance, there were already proposals to lower the upper limit of the reference range to 2.5 mIU/L.

There is no consensus on exactly when to start thyroid hormone replacement therapy based on TSH levels. The only point where there is general agreement is that once TSH climbs above 10 mIU/L, treatment is necessary. It’s worth noting that while we still lack a unified approach for values between 4.5 and 10 mIU/L, the debate has already moved further down the scale—now doctors are questioning what to do with readings between 2.5 and 4.5 mIU/L.

It seems like some colleagues—especially those practicing in private clinics—are already adopting certain American guidelines. They're treating any TSH value above 3 mIU/L as elevated, which leads to them prescribing therapy in quite a significant number of cases.

Treatment should be considered for women with subclinical hypothyroidism who are planning pregnancy, those struggling with infertility, or those currently pregnant. There is also a significant debate regarding whether therapy is warranted in cases involving a goiter, overt symptoms—like chronic fatigue or depression—or elevated antibody levels.

Strictly following our guidelines, if your fT4 levels are within the normal range, the recommendation would be to simply monitor both fT4 and TSH every six months without starting any treatment.

Since you've listed quite a few different symptoms here, we really need to stick to the principle of treating every patient as an individual case. It’s also vital to rule out other underlying conditions that might present with a similar clinical picture.
Jason Grant85 Jason Grant85 Member
22 messages
joined May 2017
#2890 ·
Maria Fisher46 said:Dear lady,

you didn't mention what your fT4 (T4) levels actually are!

Based on the current American Thyroid Association guidelines for the rational diagnosis of thyroid function disorders—which have been the standard for quite some time now—TSH values around 4.18 mIU/L are still considered within the normal range. There are exceptions, of course; for instance, pregnant women require lower reference ranges (anywhere from 2.5 to 3.0 mIU/L depending on which trimester they are in). On the flip side, some research suggests that for people over 80, a TSH value as high as 7.0 mIU/L might just be a natural part of the aging process.

The thing is, though—and this is where it gets tricky—there really isn't a universal consensus on what "normal" TSH levels should be. We’ve seen proposals as far back as 1986 suggesting we should lower the upper limit of the TSH reference interval to 2.5 mIU/L.

There is simply no agreement on exactly at what point someone should start thyroid hormone replacement therapy. The one area where most experts generally agree is that if TSH climbs above 10 mIU/L, you need to start treatment. But beyond that? It's a gray area. People are still debating the 4.5–10 mIU/L range, and nowadays, there's even a heated discussion about whether we should be concerned with values between 2.5 and 4.5 mIU/L.

It seems to me that some doctors—especially those working in private clinics—are already leaning toward certain American suggestions, where any TSH above 3 mIU/L is viewed as elevated and often warrants medication in many cases.

Generally speaking, therapy is recommended for women with subclinical hypothyroidism who are planning a pregnancy, those struggling with infertility, or women who are currently pregnant. Many practitioners also suggest treatment if there's a goiter present, noticeable symptoms of hypothyroidism (like intense fatigue or depression), or elevated antibody levels.

If we look strictly at our established guidelines—and assuming your fT4 (T4) levels are normal—the recommendation would be to simply monitor your fT4 (T4) and TSH every six months without starting any medication.

However, since you mentioned experiencing a whole host of symptoms, we really have to apply the principle of treating the patient, not just the numbers. Every case is unique. You'd also want to rule out other medical conditions that can mimic these exact clinical symptoms.

Thanks so much for such a thorough explanation.
My T4 was 95, the lab messed up and didn't run the T3, and I haven't had an fT4 checked yet.

I honestly don't know what else besides my thyroid could be causing this, but my main issue is my PCP. She’s a wonderful woman—truly kind and she never hesitates to write a referral—but she always turns to me and asks, "Well, what do *you* think? Where do you want to go?" Look, I am not a doctor, and I don't spend my time scouring the internet for diseases (well, except when it comes to skin issues)—and frankly, I have neither the energy nor the desire to go wandering from hospital to hospital. I'd much prefer if she could just prescribe something if a treatment exists. 😁
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#2891 ·
Lisa Perez37 said:Thanks for the thorough breakdown.
My T4 is 95, they missed the T3 due to a lab error, and free T4 wasn't ordered.

I'm not sure what else to look at besides my thyroid, but the real issue is my primary care physician. She’s perfectly nice and doesn't sting when it comes to writing referrals, but she constantly asks me what I think or where I want to go. I’m not a doctor, nor am I someone who spends their time Googling symptoms (unless it involves skincare), and frankly, I have neither the energy nor the desire to hunt down specialists. I'd much prefer if she just gave me a solution if one exists.😁

Ma'am,

In your situation, caution is necessary. When you have symptoms that mimic hypothyroidism, there's a risk of masking an underlying condition—especially since your T4 levels are normal and your TSH is sitting right at the upper limit of the range. A comprehensive clinical exam is needed, along with basic labs to check for anemia and to assess kidney, liver, and heart function. Since your family doctor is open to suggestions, seeing an internist or an endocrinologist would be a logical next step.
Paul Thomas27 Paul Thomas27 Newcomer
3 messages
joined Sep 2020
#2892 ·
My hematologist’s report mentions I need tests for urate and bilirubin, but my referral just says "pain" instead. I was wondering, is "pain" some kind of shorthand code for checking those specific levels?
Jason Grant85 Jason Grant85 Member
22 messages
joined May 2017
#2893 ·
Maria Fisher46 said:Hello there,

In your situation, you really need to be careful—one must ensure that the symptoms you're mimicking—those typical signs of an underactive thyroid—aren't actually masking some other underlying illness or disorder. This is especially important since your T4 levels are perfectly normal and your TSH is sitting right at the upper limit of the standard range. Because of that, a thorough clinical examination is necessary—I mean, you really need to run some basic lab work to check for things like anemia, kidney function, liver health, heart stability, and so on. If your primary care physician is offering the option, seeing an internist and/or an endocrinologist would definitely be a smart move.

I just had my MRI, and it turns out my Hashimoto's has progressed, so I've been started on Euthyrox.
Thanks again so much for all the help!
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#2894 ·
Paul Thomas27 said:My hematologist requested uric acid and bilirubin tests, but my referral just lists "bil." instead. Is "bil" some sort of shorthand for both uric acid and bilirubin?

No. It’s likely a typo. They probably meant to write "bil." as an abbreviation for bilirubin, and the uric acid test simply got left off the paperwork.
Paul Thomas27 Paul Thomas27 Newcomer
3 messages
joined Sep 2020
#2895 ·
Maria Fisher46 said:Actually, I don't think so. It was probably just a typo on the lab order—they likely meant to write "bil." as an abbreviation for bilirubin, and they just forgot to include the urate.

Thanks!
Peter Rogers Peter Rogers Active Member
60 messages
joined Dec 2011
#2896 ·
(image)[/IMG]

Hey everyone, looking at these blood work results, is it possible that this is "just" heavy and frequent menstrual bleeding causing all this, or should I be worried about something else—like those low neutrophil counts?
The patient is a 40-year-old woman, slightly overweight but not obese, pretty active, and her diet is decent enough (good food choices, just a messy eating and sleep schedule).
She’s been dealing with constant fatigue, dizziness, and some real trouble with focus and concentration.
Zachary Gomez Zachary Gomez Member
33 messages
joined Sep 2014
#2897 ·
To looks like anemia combined with some sort of inflammation to me. Perhaps the specialists will have more insight...
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#2898 ·
Emily Ortiz27 said:(image)[/IMG]

Hi. Given these blood results, could heavy and frequent menstrual bleeding be the sole cause, or should I worry about other factors (like these low neutrophil counts)?
The patient is a 40-year-old female, overweight but not obese, active, with moderate dietary habits (decent food choices, though irregular meal and sleep schedules).
Symptoms include fatigue, dizziness, and issues with focus and concentration.

I don't see any signs of inflammation—though there isn't even a CRP listed. That said, those symptoms could certainly be attributed to iron-deficiency anemia, even if it's mild. Regardless of the heavy periods, one must be cautious; you need to confirm if that’s truly the culprit or if there's potential hidden GI bleeding. Ferritin levels need to be checked to assess iron stores, urine should be tested, and running an occult blood test on stool three times wouldn't be a bad idea. An internal medicine consult and a gynecological exam are necessary before prescribing iron supplements blindly. The neutrophil values are slightly low, but since they remain above 1500/mcL, it doesn't qualify as neutropenia. For now, monitoring is sufficient.
velvetbear372 velvetbear372 Active Member
56 messages
joined Aug 2018
#2899 ·
Hello.

Could an expert please help me interpret these results? I’ve been looking over the recent discussions regarding thyroid management—specifically the nuances of treating Hashimoto's—and I wanted to weigh in on a few points. Regarding the efficacy of Euthyrox versus other options: there seems to be a lot of debate. In my experience, consistency is everything. It isn't just about the dosage; it's about how your specific body processes it. I noticed what Nicholas Myers mentioned earlier about the diagnostic hurdles. It really highlights why having access to high-quality imaging, like an MRI, is so vital for getting a clear picture of what’s actually happening internally. You can't manage what you haven't accurately measured. To the point raised by Douglas Harris4—yes, the side effects can be taxing. It’s a delicate balancing act—trying to find that "sweet spot" where your levels are stable without triggering those uncomfortable palpitations. It's a marathon, not a sprint. We have to rely on the guidance provided by institutions like the American Thyroid Association to ensure we aren't just guessing. Let's keep sharing what works. , https://i.ibb.co/NrQdP76/h.png
Drew Sanchez82 Drew Sanchez82 Active Member
149 messages
joined Nov 2010
#2900 ·
Hey there. I wasn't quite sure where else to drop this question, so I figured I'd just post it here.
I was reading online that you can get testing for Huntington disease done at the Mayo Clinic. If that's actually the case, does it work through my insurance with a referral, or is it something I have to pay for out of pocket?

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