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Lab results - looking for opinions [PLEASE READ 1ST POST]

Started by vividsailor7 · · 👁 111 views · 3.9K replies

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Participants vividsailor7redcrane22Sandra Rivera37swiftbear86melloworca6Dana Martin87ironskipper80mellowgardener15goldenmarlin6analogbison13Nicholas Myersstormygardener34Roger RodriguezDonna Mitchell3Kenneth Vaughn2Laura Ward98briskseal32Susan Vaughn46Zachary Lewis4driftingmason52rustyheron55Laura Chavez47vividstag24lonecanyon8 …
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3141 ·
Sandra Vaughn82 said:I'm wondering if elevated immunoglobulin (31) and ANA (1:2500) levels are linked to antibodies appearing two weeks after the first dose of Pfizer. Everything else looks normal.

You had leukopenia, didn't you?

It won't be from Pfizer's vaccine. In your case, this points toward systemic lupus erythematosus (given the hypergammaglobulinemia and significant ANA titer) or perhaps another type of systemic connective tissue disease. Are you experiencing any symptoms? Is the leukopenia still present?
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3142 ·
Maria Fisher46 said:You were dealing with leukopenia, right?

It’s not going to be from Pfizer's vaccine. In your case, this could point toward systemic lupus erythematosus (hypergammaglobulinemia and significant ANA titers) or perhaps some other systemic connective tissue disease. Are you experiencing any symptoms? Is the leukopenia still showing up...


No symptoms at all, just that my white blood cell count has been stuck at 2.8 for about a year now...
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3143 ·
Sandra Vaughn82 said:No issues besides low white blood cell counts—sitting at 2.8 for about a year now.

If memory serves, didn't you mention some musculoskeletal issues that require NSAIDs? So, there's more to the story than just the labs...
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3144 ·
Sandra Vaughn82 said:I haven't had any symptoms, just low white blood cell counts at 2.8, which has been consistent for about a year now...


So I went to see a hematologist, and they ordered some more detailed blood work. My ANA came back elevated, but the white cells are still right at the bottom limit, and they ran an electrophoresis too. Nothing pointed to a specific diagnosis yet, so they just want me to redo the ANA in eight weeks...
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3145 ·
Sandra Vaughn82 said:That’s why I went to see my hematologist. They ordered some more detailed blood work, but so far, only the anemia is elevated while my white cell count is still sitting right at the low end of the normal range. They also ran an electrophoresis, but nothing pointed toward a specific diagnosis yet... just told me to come back and recheck the anemia levels in about eight weeks...


I've been having some issues with my cervical spine lately, so I was taking some medication... but I've started scaling back on the dosage...
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3146 ·
Excuse me,

In your previous posts, you mentioned hypertension and tinnitus, which suggests there’s more going on here than just a low white blood cell count. We aren't going to get very far if we just keep digging through old data points. In my view, a rheumatology consult is necessary to rule out systemic rheumatic diseases. Before that appointment, you should definitely have your complement levels checked (C3, C4, CH50) and test for antiphospholipid antibodies (aCL IgM, IgG, LAC, beta-GPI). If you've only had protein electrophoresis, you'll need to check your IgA, IgM, and IgG levels as well. Make sure a full biochemistry panel is completed if anything was missed, along with a urinalysis to check the protein-to-creatinine ratio and an eGFR calculation.

Do you have the fluorescence pattern results if the ANA was determined via IIF? And was an ENA screen performed—was that negative as well?
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3147 ·
I don't have tinnitus. I saw an ENT specialist, and it turns out that sound in my neck is actually cervical syndrome caused by degenerative changes (I already had an MRI). I'll send over the details of what was done, along with the results from my follow-up appointment with the hematologist. Thank you so much... I really appreciate how hard you all are working to help me make sense of everything.

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Carol Lopez23 Carol Lopez23 Member
30 messages
joined Apr 2005
#3148 ·
Given the specific results we’re seeing from the electrophoresis, I believe it would be highly prudent to proceed with an immunofixation test as well.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3149 ·
Keith Gonzalez said:Given those electrophoresis results, it would be prudent to follow up with an immunofixation test.

Well, excuse me! Not even a "good morning," how are things going... 🙄

Just swoops in and disappears without a word. 🙂

Kids these days... ☕
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3150 ·
Sandra Vaughn82 said:I don't have tinnitus. I saw an ENT, and it turns out that sound in my neck is just cervical syndrome due to degenerative changes—I've already had an MRI. I'll send over the results once I have them, along with the follow-up from the hematologist. Thank you; I appreciate the effort to help me make sense of all this.

Ma'am,

The CRP levels are elevated too.

It looks like an ENA screen hasn't been run, and there’s no ANA fluorescence pattern listed either.

What about the ESR?

I'd suggest getting the ANA and ENA screen done at either the Mayo Clinic or the Cleveland Clinic. You might be able to coordinate this through your primary care physician—sometimes you can just mail the sample with a referral instead of traveling there in person. Regarding antiphospholipid antibodies, they've only tested for anticardiolipin. Also, it isn't entirely clear why spirometry with DLCO is being ordered; typically, that's part of the workup for systemic connective tissue diseases, which seem to be already confirmed here.

Have you checked your liver enzymes yet?

Naturally, alongside the current workup, completing the hematological evaluation is necessary. I agree with the colleague's recommendation.
Carol Lopez23 Carol Lopez23 Member
30 messages
joined Apr 2005
#3151 ·
Maria Fisher46 said:Not him! He won't even offer a simple "hello," or ask how you're doing, or engage in any small talk... 🙄

He just swoops in and vanishes without so much as a polite nod! 🙂

Ah, the younger generation... ☕

Going full throttle. 🤣

Regardless, let us continue to provide as much assistance as possible through this forum. 😁
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3152 ·
Maria Fisher46 said:Hello,

The CRP levels are elevated too!

I noticed they didn't run an ENA screen, and there's no fluorescence pattern listed either.

What about the ESR?

I’d suggest getting the ANA and ENA screens done at either the Mayo Clinic or the Cleveland Clinic. You might be able to coordinate this through a primary care doctor—sometimes you can just send the sample with a referral without having to show up in person. As for the antiphospholipid antibodies, they only checked for anticardiolipin. Also, I'm not entirely sure why spirometry and CO diffusion capacity were ordered; usually, that's part of the workup, but it seems a bit much if systemic connective tissue disease is already confirmed.

Have you had your liver enzymes checked?

Given everything else being looked into, I agree with the colleague's recommendation that a hematology workup is definitely needed.


My amylase is slightly high. My doctor mentioned it might be because of a small gallstone (1.5cm) that's been sitting there for years. I'm from San Francisco, so I'll probably just get the rest of the testing done at the local hospital there. Thanks.
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3153 ·
Sandra Vaughn82 said:My amylase levels are slightly elevated. My doctor mentioned it might be due to a small gallstone I've had for years that hasn't caused issues yet. I'm from San Francisco, so I'll just leave the rest of the details for when I visit the Mayo Clinic. Thanks...


Sedimentation rate of 16
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3154 ·
Sandra Vaughn82 said:My amylase levels are slightly elevated. My doctor mentioned it might be due to a small gallstone (about 1.5cm) that I've had for years and hasn't caused issues until now. I'm based in San Francisco, so I'll just leave the rest of the details for my doctors at the Mayo Clinic. Thanks...
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3155 ·
I’ve reorganized your lab results photos, scrubbing out the sections containing your private info. Moving forward, please be more careful about redacting personal details before posting them here—it's basic self-protection.

Regarding Ana/Ena’s results, I suggest using either the Mayo Clinic or the labs in Washington, D.C. There’s a reason for that recommendation: their immunology testing is reliable and validated. But, ultimately, the choice is yours.
Kenneth Sanders97 Kenneth Sanders97 Newcomer
6 messages
joined Aug 2007
#3156 ·
Hey everyone, I’m a bit of a hypochondriac—at least I’m self-aware about it—and I’ve got a gallbladder surgery coming up. Other than that, I feel fine, all my labs look good, but I am slightly tripping over my sodium levels being right at the bottom edge, at 137.

My only other thing was cholesterol hitting 5.1 (normal is under 5), and that "bad" LDL was 3.2 (normal is under 3), but everything else seems totally fine. No diabetes, kidneys look great on ultrasound, etc. I’m a 37-year-old woman and I am overweight, but these were just part of my standard pre-op screenings.

Just trying to make sure I don't spiral into a panic if there's really nothing to worry about (which, most of the time, there isn't).

Thanks.

Reference range 137-146
Sandra Vaughn82 Sandra Vaughn82 Member
14 messages
joined Apr 2021
#3157 ·
Maria Fisher46 said:I went ahead and edited your lab results photos to blur out your private information. In the future, please make sure to scrub any personal details before posting them here on the forum—it’s really just for your own privacy...

When it comes to getting ANA testing done, I’d suggest either the Mayo Clinic or a major hospital in Washington, D.C. I recommend them because their immunology labs are highly reliable and fully validated, but ultimately, the choice is yours...


Thanks, I don't spend a ton of time on this forum, so I'm not entirely sure
electricmarlin62 electricmarlin62 Member
11 messages
joined Jan 2015
#3158 ·
https://ibb.co/c2W3fCb

Hey there... could you guys take a look at these results for me?
Man here is 58... dealt with hemorrhoids for a long time but hasn't really had any issues lately.. Thanks!
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3159 ·
Lisa Chase90 said:Hi everyone. I’m a bit of a hypochondriac—at least, I’m self-aware enough to admit it. I’m prepping for gallbladder surgery. Aside from that, I feel fine and my labs look good, though my sodium is sitting right at the low end of the scale: 137.

The only outlier was total cholesterol at 5.1 (normal is under 5), while my "bad" LDL was 3.2 (normal is under 3). Everything else is steady—no diabetes, kidneys are fine, and ultrasound looks clear. I'm a 37-year-old woman, carrying some extra weight, and these tests were just part of my pre-op screening.

Just trying not to spiral if there isn't actually a reason to worry (which is usually the case).

Thanks.

Reference range 137-146

Ma'am,

It isn't unusual for individuals dealing with overweight or obesity to show slightly lower sodium levels or results that sit at the bottom of the normal range. Generally speaking, you shouldn't lose sleep over this specific value.

Good luck with the surgery!
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3160 ·
electricmarlin62 said:https://ibb.co/c2W3fCb

Hello... Could you please take a look at these results?
Male, 58 years old. He has dealt with hemorrhoids for many years, though they haven't been an issue lately. Thank you.

To whom it may concern,

You didn't mention why this testing was ordered. What symptoms is the patient experiencing?

In any case, there are abnormalities here that require follow-up, most notably the anemia. However, the data is incomplete. There is no differential blood count provided, yet leukocytosis is present; therefore, a CBC with differential is definitely necessary. Sedimentation and CRP need to be determined, and the biochemistry should be supplemented with LDH—plus, bilirubin and ALP are missing. It would also be prudent to check ferritin and serum protein electrophoresis.

Anemia paired with elevated urea, while creatinine remains within the normal range, can sometimes point toward gastrointestinal bleeding (though, granted, high urea can also stem from dehydration or other issues). As a next step, a fecal occult blood test performed three times is required.

Depending on the symptoms and subsequent findings, the patient will need further workup—laboratory tests, imaging, and specialist consultations. I have only listed tests typically handled at the primary care level before a referral to a specialist.

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