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Lab results - looking for opinions [PLEASE READ 1ST POST]

Started by vividsailor7 · · 👁 56 views · 3.9K replies

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Participants vividsailor7redcrane22Sandra Rivera37swiftbear86melloworca6Dana Martin87ironskipper80mellowgardener15goldenmarlin6analogbison13Nicholas Myersstormygardener34Roger RodriguezDonna Mitchell3Kenneth Vaughn2Laura Ward98briskseal32Susan Vaughn46Zachary Lewis4driftingmason52rustyheron55Laura Chavez47vividstag24lonecanyon8 …
Hannah Stewart27 Hannah Stewart27 Member
10 messages
joined Dec 2021
#3461 ·
Hi everyone,

I really appreciate the clarification. My main issue is that the waiting list is absolutely massive right now. It feels impossible to get any real answers from anyone, so I decided to follow up on my inquiry after getting my latest test results—especially since my specialist appointment isn't scheduled for several months. Also, seeing these vitamin D levels was a first for me; I wasn't quite sure why they would be relevant from a gastroenterology standpoint.

Thanks again.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3462 ·
Harold Garcia60 said:@Nicholas Myers Thanks for the reply. Please excuse my previous post; it was a bit blunt. I’m attaching my son's lab results from his distal renal tubular acidosis diagnosis, along with his most recent ones. That redness mentioned in the last discharge summary has completely cleared up.

Hello,

I've reviewed the labs. At this stage, the condition appears well-managed, and the results are satisfactory. It seems the child is receiving excellent care. Everything has been handled according to standard clinical best practices.

With proper management, normal growth and development are achievable while preserving kidney function. Depending on what the genetic testing shows, there is a possibility of extra-renal complications—specifically sensorineural deafness or, occasionally, hemolytic anemia. Has the genetic report come back yet?
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3463 ·
vividcrane24 said:Respectfully,

I'd appreciate some perspective regarding shifted lymphocyte counts—specifically, elevated levels paired with a drop in others.
Neutrophil count and what follow-up tests are actually necessary.

I was diagnosed with Hashimoto's about ten years ago.
I’m skipping the medication for now. My TSH levels are still sitting within the normal range.
I wonder if this condition could lead to low levels:
Neutrophil granulocytes.
sada: 28.9% relative. (44-72) A few years back: 98.6, 104.7.
1.40 10*9/L A few years back, looking at the range between 2.06 and 6.49: it was sitting at 1.90.
Those elevated levels. Lymphocytes at 55.5%. (20 - 46), a few years back: 50.0

The doctor didn't actually provide a link like that. He just made a passing comment about neutropenia—specifically regarding some potential triggers.
They also sent me for a urine culture. I’m still dealing with that frequent urge to go, and frankly, I still don't know what's driving it. Previously, I was prescribed Ninian Nolicin because my white blood cell counts kept spiking—hitting levels like 10-15, 10-12, or even 12-17.
Everything looked fine from a gynecological standpoint, but my doctor is sending me back for another appointment. Apparently, they need to run some swabs since they weren't taken during the initial visit.

To whom it may concern,

If neutropenia becomes a long-term issue, you need a full workup. Don't bother listing specific absolute neutrophil counts or dates; those percentages don't tell us much in this context. Just get the investigation started.

Any medications currently in your rotation? Any specific health issues you're dealing with? Or perhaps someone in your family struggles with neutropenia?

A full workup is necessary. This should include a thorough physical exam—focusing specifically on the lymph nodes, liver, and spleen—alongside a CBC, metabolic panel, ESR, and CRP. You'll also need to check B12 and folic acid levels, run ANA, ENA, and RF tests, perform serum protein electrophoresis, and test for antineutrophil antibodies. Complete immunophenotyping of peripheral blood lymphocytes and HIV serology are also required. Once those results are in, schedule an appointment with a hematologist to determine the next steps. Depending on what the clinical exam and history reveal, you might also need to have your blood counts monitored two or three times a week for the next six to eight weeks.

The processing is sufficiently accurate.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3464 ·
Hannah Stewart27 said:To whom it may concern,

Thanks for clearing that up. The issue is the waiting list is massive; nobody seems able to provide concrete answers right now. I decided to follow up after getting my latest test results, though I'm still stuck waiting months for a specialist review. As for the vitamin D levels, this is my first time seeing them mentioned in this light—I didn't realize they were relevant from a gastroenterology standpoint.

Thanks again.

Ma'am,

While you wait for those appointments, it might be prudent to run a few tests: ANA, ENA, C3, C4, CH50, immunoglobulin levels (IgG, A, M, E), thyroid antibodies (unless already covered), and a fecal fat test for malabsorption.

What does the CBC look like? SED rate? CRP? Iron status? Electrolytes like Mg, Ca, Na, K, and Cl? Pancreatic enzymes (amylase, lipase)? Lipid panel (cholesterol, triglycerides)? Serum proteins? albumin? Coagulation factors (PT, PTT, fibrinogen)?

Since doubling the dose of Claritin didn't do the trick, I’d suggest talking to your primary care physician about switching antihistamines. You could try Xyzal at 5 mg twice a day. If there's no improvement after a week, try 5 mg in the morning and 10 mg at night. If that fails after another week, you could move to a full double dose of 10 mg twice daily.
Hannah Stewart27 Hannah Stewart27 Member
10 messages
joined Dec 2021
#3465 ·
Thank you all for the responses, perspectives, and suggestions. From our discussion, I’ve pulled these specific values:

C3c - 1 (0.9-1.8) - assuming what you mentioned is correct...
C4 - 0.2 (0.1-0.4
Immunoglobulin A - 0.94 (0.70-4)
Immunoglobulin M - 1.51 (0.40-2.30
Immunoglobulin G - 15 (7.00-16.00)
(S)Alpha amylase 66 (23-91)
(U)Alpha amylase 374 (0-400)
albumin/Globulin 2.13
Cholesterol 4.7 HDL cholesterol - 1.5 >1.2
LDL cholesterol - 3.2 Triglycerides - 0.6 Ferritin 106 (20-300)

Everything listed looks fine; my heart health is excellent. Still waiting on the stool sample results. My thyroid is perfectly normal—we even did a TSH test, which came back clear.

The main things that have shifted compared to six weeks ago are:

Alpha 2 globulins - 7.8 : 6.5 (7.0-11.0)
Beta globulins - 7.6 : 4.9 (9.0-14.0)
Gamma globulins - 20.4 : 18.2 (12.0-20.0)
Beta globulins (dr. fraction) - 5.6 : 3.5 (6.0-10.0)
My vitamin D was 69.5 three months ago, but it's down to 14.7 now.

Apologies if any of this data feels redundant.
David Flores68 David Flores68 Newcomer
3 messages
joined Mar 2018
#3466 ·
Maria Fisher46 said:It’s a complicated situation, but I don't see a clear diagnosis emerging from it just yet. Honestly, it might be time to start a formal diagnostic workup. Since you aren't dealing with joint swelling at the moment—as I mentioned before—I'd suggest seeing a dermatologist first; from there, you'll likely need to schedule a biopsy.

Thanks for the input! My gut feeling was also that this leans more toward dermatology than rheumatology—so, hopefully, my doctor will refer me to a specialist. If not, I'll just book a private appointment myself.

I also wanted to get your take on these lab results

https://i.postimg.cc/xC3gkqsf/oba-reuma-nalaza.jpg

Everything looks negative to me—is that right? And does this definitively rule out any kind of rheumatic disease?
vividcrane24 vividcrane24 Newcomer
5 messages
joined Feb 2022
#3467 ·
Maria Fisher46 said:Dear lady,

If this neutropenia has been lingering for quite some time—and please, don't just give me percentages, I need the actual absolute neutrophil count along with specific dates, because those percentages you mentioned aren't particularly helpful—you really need a full workup.

Are you currently on any medications? Are you experiencing any symptoms? Is there anyone else in your family history dealing with neutropenia?

It would be prudent to undergo a comprehensive evaluation (specifically checking the lymph nodes, liver, and spleen), a peripheral blood smear, ESR, CRP, biochemistry, B12 and folic acid levels, ANA, ENA, RF, serum protein electrophoresis, antineutrophil antibodies, peripheral blood lymphocyte immunophenotyping, and HIV serology; once you have those results, you should consult a hematologist to decide on the next steps. Depending on what the clinical exam and your history show, we might also consider repeating your CBC two or three times a week over the next six to eight weeks.

The diagnostic approach suggested is correct.

Sir,

My apologies for being imprecise regarding the most critical details.
These low neutrophil granulocyte counts aren't exactly a recent development:

rel % (44 - 72) from the results I have in front of me right now:
02/22 - 28.9
2018 - 40.4
2014 - 37.0

10*9/L (2.06 - 6.49)
2/2022 - 1.40
2018 - 1.90

There is no history of neutropenia in my family, and as for how I've been feeling—fatigue, anxiety, bloating, constipation, irregular cycles—it all seems to align with my Hashimoto and PCOS. Regarding medication, I've been taking Emaner and normabel pp over the years, plus I recently started Gynositol per my gynecologist's advice.
While everything is still speculative and pending a complete investigation, I am wondering if this neutropenia could be linked to Hashimoto, especially if we factor in the EBV virus as a potential trigger? I've been reading that prolonged neutropenia (and certain viral infections) can sometimes be tied to the Epstein-Barr virus, which has been considered one of the culprits behind chronic thyroiditis.
On a side note, I'm curious about your take on starting hormone replacement therapy for thyroiditis to manage symptoms, even when the TSH levels appear perfectly normal?

Thank you for the response; I will certainly have to insist on getting these tests done.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3468 ·
Hannah Stewart27 said:Thank you all for the feedback and suggestions. I've pulled the specific figures from my reports:

C3c - 1 (0.9-1.8) - assuming what you mentioned is correct...
C4 - 0.2 (0.1-0.4
Immunoglobulin A - 0.94 (0.70-4)
Immunoglobulin M - 1.51 (0.40-2.30
Immunoglobulin G - 15 (7.00-16.00)
(S)Alpha amylase 66 (23-91)
(U)Alpha amylase 374 (0-400)
Albumin/Globulin 2.13
Cholesterol 4.7 HDL cholesterol - 1.5 >1.2
LDL cholesterol - 3.2 Triglycerides - 0.6 Ferritin 106 (20-300)

The numbers look fine overall; the CBC is excellent. Still waiting on stool results. Thyroid function is normal—even had a TSH test done, which came back clear.

What has shifted compared to six weeks ago is this (previous vs. current):

Alpha-2 globulins - 7.8 : 6.5 (7.0-11.0)
Beta globulins - 7.6 : 4.9 (9.0-14.0)
Gamma globulins - 20.4 : 18.2 (12.0-20.0)
Beta globulins (subfraction) - 5.6 : 3.5 (6.0-10.0)
Vitamin D was 69.5 three months ago; now it's 14.7.

Apologies if any of this data is extraneous.

The picture isn't complete yet. We're still missing the Apple and ENA results.

Also, you should verify the units for the Vitamin D tests. Are both labs using the exact same measurement scale?

There are fluctuations in the Alpha-2 and gamma globulin levels, though they might still fall within an acceptable range (it would be helpful to see both percentages and values in g/L for a better assessment). The only consistent trend here is the significant drop in beta globulin levels.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3469 ·
David Flores68 said:Thanks for the input. My gut feeling was also that this looks more like a skin issue than anything rheumatological. Hopefully, my doctor refers me to a dermatologist; if not, I'll just book a private appointment.

Just wanted to follow up regarding these lab results.

https://i.postimg.cc/xC3gkqsf/oba-reuma-nalaza.jpg

It all looks negative to me—is that right? And does this officially rule out any kind of rheumatic disease?

No. There are many other tests and diagnostic steps required before you can rule out an autoimmune or rheumatic condition. So, my answer is that we cannot say a rheumatic cause for your symptoms is ruled out just yet.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3470 ·
vividcrane24 said:To whom it may concern,

My apologies for the imprecise summary earlier.
The low neutrophil counts aren't a new development:

Relative % (44 - 72) from my current labs:
02/22 - 28.9
2018 - 40.4
2014 - 37.0

Absolute count 10*9/L (2.06 - 6.49)
02/22 - 1.40
2018 - 1.90

There’s no history of neutropenia in my family. Regarding my general health—fatigue, anxiety, bloating, constipation, irregular cycles—these symptoms align with both Hashimoto and PCOS. My medication history includes Emaner and Normabel pp over the years, plus Gynositol recently for gynecological reasons.
Since everything is still being investigated, I'm wondering if this neutropenia could be linked to Hashimoto, especially considering EBV as a potential trigger? I've read that long-term neutropenia (and certain viral infections) can be tied to the Epstein-Barr virus, which is also considered a possible cause of chronic thyroiditis.
On a side note, what is your take on starting hormone replacement therapy for thyroiditis when symptoms persist despite normal TSH levels?

Thanks for the response; I will certainly insist on those tests.

Based on what you've shared, the neutropenia has persisted for several years. It appears to coincide with the diagnosis of an autoimmune thyroid disease. In this light, there is a lower probability of an underlying serious pathology causing the neutropenia (though nothing can be ruled out entirely). As you suggested, it is quite possible the neutropenia is connected to the autoimmune thyroid condition; this isn't uncommon in clinical practice, particularly with milder cases where no other symptoms of illness are present. Regardless, the neutropenia should still be fully evaluated.

It seems unlikely that EBV would be the driver behind neutropenia that has lasted for years.

If the patient is in a euthyroid state, levothyroxine replacement therapy is not indicated.
vividcrane24 vividcrane24 Newcomer
5 messages
joined Feb 2022
#3471 ·
Maria Fisher46 said:Based on what you've shared, it looks like this neutropenia has been hanging around for quite some time—years, actually—and it seems likely to coincide with the diagnosis of an autoimmune thyroid condition. In this light, there’s a lower probability that there's something more sinister driving this neutropenia (though we can't rule it out entirely), and it's entirely possible, just as you suspected, that the two issues are linked via the autoimmune thyroid disease; this isn't exactly uncommon in clinical practice, particularly when dealing with milder cases of neutropenia where no other symptoms of a different underlying illness are present. Regardless, I believe a full workup for the neutropenia should be conducted.

I find it highly unlikely that EBV would be the culprit behind neutropenia that persists for years on end.

As long as the patient remains euthyroid, starting replacement therapy with levothyroxine is not indicated.

Dear Doctor,

I just received my urine culture results, and they show a clear presence of "Enterococcus faecalis".

View on imgur

Could you please interpret this and advise on how I should approach treatment for the chronic, frequent urge to urinate accompanied by a sensation of inflammation or pressure in my lower abdomen and pelvic region (which I mentioned in previous posts)? To reiterate, I was previously prescribed Ninur or Nolicin following a diagnosis of cystitis, but unfortunately, the treatment didn't provide any relief.
Is it possible that the neutropenia could be somehow connected to these urinary issues?
I would appreciate your perspective on this...
Hannah Stewart27 Hannah Stewart27 Member
10 messages
joined Dec 2021
#3472 ·
Hello,

Thank you. I’m going to try to push for the ANA and ENA panels, though everything feels a bit like a mystery right now—including how exactly malabsorption would manifest if those tests come back positive.

Regarding Vitamin D, yes, we were using the same units. Three months ago, I was at 69.5 nmol/L, but it has since dropped to 14.7 nmol/L (target range: 75-100).

The protein electrophoresis results, provided in both % and g/L, are as follows:

12/23/2021:
Albumin - 61.5% (52-68)
Alpha 1 globulins 2.7% (2-5)
Alpha 2 globulins 7.8% (7-11)
Beta globulins 7.6% (9-14)
Gamma globulins 20.4% (12-20)
Albumin 45.5 g/L (35-49)
Alpha 1 globulins 2.0 g/L (1-4)
Alpha 2 globulins 5.8 g/L (4-11)
Beta globulins 5.6 g/L (6-10)
Gamma globulins 15.1 g/L (8-14)
Albumin/Globulin ratio 1.60

02/10/2022:
Albumin - 68.0% (52-68)
Alpha 1 globulins 2.4% (2-5)
Alpha 2 globulins 6.5% (7-11)
Beta globulins 4.9% (9-14)
Gamma globulins 18.2% (12-20)
Albumin 48.3 g/L (35-49)
Alpha 1 globulins 1.7 g/L (1-4)
Alpha 2 globulins 4.6 g/L (4-11)
Beta globulins 3.5 g/L (6-10)
Gamma globulins 12.9 g/L (8-14)
Albumin/Globulin ratio 2.13

I appreciate all the information provided so far.
David Flores68 David Flores68 Newcomer
3 messages
joined Mar 2018
#3473 ·
Maria Fisher46 said:No, there are still quite a few other tests and diagnostic steps required to rule out rheumatic disease—so my answer is that, at this stage, we cannot say that a rheumatic condition isn't part of the underlying cause of your symptoms.

Much appreciated!
Bryan Taylor5 Bryan Taylor5 Newcomer
2 messages
joined May 2007
#3474 ·
Can anyone help me make sense of these blood results? My platelet count is high, and my doctor recommended seeing a hematologist—which honestly has me a bit on edge:

Platelets 541 ( 158-424 )
WBC 13 ( 3.4-9.7 )
Baso% 5 ( 0-1 )

Biochemistry
GGT 7 ( 9-35 )

Everything else falls within the normal range.
I’m not sure if there’s any connection to the daily headaches I've been dealing with for the last two and a half weeks—I’ve been taking Advil once a day (not every single day, but pretty frequently since the headaches started) —or perhaps the two tooth infections I'm currently getting treated for. I figured the headaches were just tied to the dental issues.

Thanks
Carol Lopez23 Carol Lopez23 Member
30 messages
joined Apr 2005
#3475 ·
Amanda Parker13 said:Would anyone be able to help me interpret these blood test results? I am quite concerned about my elevated platelet count, and since the recommendation was to see a hematologist, I’m feeling rather unsettled by the whole situation:

Platelets 541 ( 158-424 )
White Blood Cells 13 ( 3.4-9.7 )
Baso% 5 ( 0-1 )

Biochemical tests
GGT 7 ( 9-35 )

Everything else falls within the standard reference ranges.
I am unsure if there might be a connection to the daily headaches I have been experiencing for the past two and a half weeks; I frequently take Advil (just once a day, though not every single day since the headaches started) and I am currently undergoing treatment for two dental infections. I had assumed the headaches were linked to those issues.

Thank you

It would be wise to resolve the underlying infection first, and then schedule a follow-up round of testing.
Betty Rogers2 Betty Rogers2 Member
31 messages
joined Apr 2015
#3476 ·
Maria Fisher46 said:Hi there,

I’ve gone over the labs, and I can say that the condition is well-managed right now; the results look solid. Honestly, I think the child is in good hands. Everything is being handled according to standard clinical best practices.

With the disease under control like this, steady growth and development are possible, while keeping kidney function intact. Depending on what the genetic testing shows, there’s still a chance for non-renal complications to pop up—things like sensorineural deafness or sometimes hemolytic anemia. Has the genetics report come back yet?


Thanks. For the last three months, I've been down a total rabbit hole—reading articles, scientific papers, people's stories, watching YouTube videos... you name it. It's been intense, and I feel like I've learned a lot about this condition through all that deep diving. Because of that, I'd really appreciate it if you could answer a few questions. It’s pretty obvious you actually understand this specific pathology, which is a refreshing change from most doctors we've talked to. We haven't heard back regarding the genetics yet; we sent the samples off to Newcastle Upon Tyne at the start of December.

If the disease is being managed well, does that actually lower the risk of complications, or is the possibility still hanging there? What kind of complications should we be looking out for? Like you mentioned, there's the potential for sensorineural deafness due to the EVA (Enlarged Vestibular Aqueduct) situation. To be blunt, that's our biggest fear. We're struggling to wrap our heads around it. Since the deafness is triggered by certain gene mutations in this condition, my question is: is there any glimmer of hope? Any way—whether it's natural or "official" medicine—to prevent it?

Also, nephrocalcinosis has developed in both kidneys. I'm attaching some photos. Is there any way to actually cure or clear nephrocalcinosis?

https://ibb.co/K207ZkS
https://ibb.co/2WN5Ng1

Sorry for the barrage of questions, it's just... finding out our son has this is a lot to process.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3477 ·
Hannah Stewart27 said:Sir,

Thank you. I'll try to push for the ANA and ENA panels, though everything is still a bit of a question mark right now—including how malabsorption actually works if that ends up being the diagnosis.

Regarding Vitamin D, yes, the units were identical. Three months ago, it was at 69.5 nmol/L; now it's dropped to 14.7 nmol/L (target range 75-100).

The protein electrophoresis results, in both % and g/L, are as follows:

12/23/2021:
Albumin - 61.5% (52-68)
Alpha 1 globulins 2.7% (2-5)
Alpha 2 globulins 7.8% (7-11)
Beta globulins 7.6% (9-14)
Gamma globulins 20.4% (12-20)
Albumin 45.5 g/L (35-49)
Alpha 1 globulins 2.0 g/L (1-4)
Alpha 2 globulins 5.8 g/L (4-11)
Beta globulins 5.6 g/L (6-10)
Gamma globulins 15.1 g/L (8-14)
Albumin/Globulin 1.60 1

02/10/2022:
Albumin - 68.0% (52-68)
Alpha 1 globulins 2.4% (2-5)
Alpha 2 globulins 6.5% (7-11)
Beta globulins 4.9% (9-14)
Gamma globulins 18.2% (12-20)
Albumin 48.3 g/L (35-49)
Alpha 1 globulins 1.7 g/L (1-4)
Alpha 2 globulins 4.6 g/L (4-11)
Beta globulins 3.5 g/L (6-10)
Gamma globulins 12.9 g/L (8-14)
Albumin/Globulin 2.13 1

I appreciate all the information provided so far.

Looking at these side-by-side—which is why presenting full sets for comparison is always better—the drop in beta globulins stands out as significant. The Vitamin D level has also plummeted, though we have to consider that it’s winter here in the States; less sunlight likely played a role in that decline.

"Malabsorption" isn't really a diagnosis in itself. It's more of a descriptive term for a condition that can stem from a massive variety of underlying causes. This makes it notoriously difficult to pin down or treat effectively.

That said, I might have missed a detail earlier—I can't recall the very beginning of your history—but typically, patients dealing with malabsorption or malabsorption syndrome present with prominent symptoms like chronic diarrhea, weight loss, or anemia. There could be others, but I don't recall the exact specifics of how your situation first began...
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3478 ·
vividcrane24 said:Hello,

I just got my urine culture results back, and they show an evident presence of "Enterococcus faecalis."

View on imgur

Could someone interpret this and suggest a direction for treatment? (As I mentioned in a few previous posts), I've dealt with a long-standing, frequent urge to urinate accompanied by pressure or inflammation in my lower abdomen/pelvis. To reiterate, I was previously prescribed Ninur or Norfloxacin for cystitis, but there was no improvement following those treatments.
Is it possible to link my neutropenia to these urinary issues?
I would appreciate your perspective..

To the requester,

I am not convinced that an E. faecalis count of 10^3 CFU/ml is linked to the symptoms you are describing.

It seems unlikely that your urinary issues are directly tied to your mild neutropenia.

Unless something else emerges from other microbiological tests (you mentioned swabs earlier?), my suggestion would be to seek a gynecological and urological evaluation. There are specialists in urogynecology specifically; I'd recommend starting there to resolve this.

Frankly, I doubt a single course of an antibiotic sensitive to the E. faecalis found in this culture will fix chronic issues that have persisted for years.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#3479 ·
Harold Garcia60 said:Thank you. For the last three months, I've been diving deep—reading journals, scientific papers, patient stories, watching YouTube videos. It’s been an intense education on this condition. Because you clearly have a much deeper grasp of this than most doctors we've encountered, I would be grateful if you could answer a few questions. We are still waiting on the genetic results; we sent the samples to a lab in Newcastle Upon Tyne back in early December.

If the condition is well-managed, does that reduce the risk of complications, or is the probability still the same? What specific complications are you aware of? As you mentioned, there is a possibility of sensorineural hearing loss due to Enlarged Vestibular Aqueduct (EVA). To be honest, that is our greatest fear, and it's something we are struggling to accept. Since the deafness is driven by specific gene mutations, my question is: is there any hope? Any chance of a cure, whether natural or "official," to prevent it?

Additionally, nephrocalcinosis has developed in both kidneys. I'm attaching photos. Is it possible to cure or completely remove nephrocalcinosis through any means?

https://ibb.co/K207ZkS
https://ibb.co/2WN5Ng1

Forgive the many questions, but processing this diagnosis for our son has been overwhelming.

Dear Sir,

Since it is quite late, I may have overlooked some of your inquiries. I will provide brief answers for now and perhaps expand on them later.

Regarding treatment: based on current medical knowledge, nothing available can slow down, delay, or prevent hearing loss if it is genetically determined. Nothing has proven effective yet. At this stage, the only options remain hearing aids or a cochlear implant if the hearing loss progresses.

As for the nephrocalcinosis, therapy might slightly reduce it, but expecting a total reversal is unrealistic. Based on what we know today, complete removal isn't possible. However, treatment can prevent further progression, help preserve kidney function, allow for normal growth and development, prevent bone density loss, and lower the risk of kidney stones.

The known complications associated with this condition include: growth and developmental delays, rickets, osteomalacia, nephrocalcinosis, kidney stones, impaired renal function leading up to chronic kidney failure, kidney cysts, dental enamel issues, hemolytic anemia, and hearing loss in cases involving distal renal tubular acidosis. I may have missed something else given the late hour.

Therapy can be used to manage the issues I listed above.
vividcrane24 vividcrane24 Newcomer
5 messages
joined Feb 2022
#3480 ·
Maria Fisher46 said:Dear lady,

I am honestly not convinced that an Enterococcus faecalis count of 10^3 CFU/ml is actually linked to the symptoms you are describing.

Furthermore, I don't believe your urinary issues are directly tied to that mild neutropenia you mentioned.

Unless something else turns up in your other microbiology results—you mentioned swabs earlier, right?—I would suggest seeing a gynecologist and a urologist. There are even specialists in urogynecology, so I’d recommend starting your investigation there.

To be blunt, I highly doubt that just one course of an antibiotic from a sensitivity list for E. faecalis is going to magically resolve chronic issues that have been plaguing you for years.

You make a fair point; since my Pap smear came back clean, cervical swabs seem to be the only thing left to check. I have managed to secure appointments for further hematological and urological follow-ups, so I am hoping to get some actual answers regarding these persistent symptoms relatively soon.

While I wait, I am curious about how neutropenia is typically managed when it's triggered by Hashimoto (assuming all other possibilities are ruled out)?
It strikes me as quite odd that one endocrinology specialist told me he wouldn't link elevated lymphocyte counts and low neutrophils to thyroid dysfunction.
On the other hand, isn't there research suggesting that a decreased white blood cell count is frequently observed in patients dealing with autoimmune conditions, such as chronic thyroiditis, and that this possibility might even extend to those with untreated hypertension?

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