#881 ·
briskranger132 said:It isn't about the titer here, but the units.
The ANA is 99 U/ml, while the reference range is 0-55.
I have no idea if that constitutes a significant jump, 🤷especially since when I tested for Anti TPO (for my thyroid), those levels were over 1000, whereas the reference was up to 70...
Ma'am,
It is difficult to say because clinical assessment usually relies on the titer rather than the value in U/ml, as seen in this case.
Furthermore, every lab maintains its own specific range for normal values.
There are also various methods for determining ANA, some of which carry more weight or reliability than others.
When ANA is expressed as a titer, most labs consider a positive result to be between 1:40 and 1:80; if the HEp-2 cell method is used, a titer of 1:160 or higher is typically flagged.
If we assume a 1:80 titer is the threshold for positivity, then the antibody level in your results might correspond to a titer of roughly 1:160*. That would be a relatively low titer, appearing in about 5% of healthy individuals.
However, if a 1:160 titer is considered the positive mark, your result would correspond to 1:320, which occurs in approximately 3% of the healthy population.
Truthfully, I cannot speculate on the exact significance of this finding, as my experience lies with ANA antibodies expressed as titers rather than in U/ml.
Regarding the link between ANA and autoimmune thyroid diseases: yes, a positive ANA can be found in patients with Hashimoto thyroiditis and Graves' disease. Additionally, those with autoimmune thyroid issues may face an increased risk of developing other autoimmune conditions, including systemic ones.
That said, it is not standard practice to order ANA "preventatively" for patients with autoimmune thyroid disease.
ANA testing is reserved for cases where there is clear clinical suspicion of a systemic autoimmune disorder, and the physician requesting it must have a valid reason—a diagnosis of Hashimoto thyroiditis alone does not suffice.
If the ANA is positive and clinical symptoms are present, further investigation is required to test for other antibodies.
Best regards. 🙂
*Note: This method of "converting" units into a titer is based on my own logical reasoning. I must admit I haven't found confirmation for this specific calculation in medical literature, so I could be entirely off base; please take this with a grain of salt.
briskstag13 said:What could the symptoms be? And is it possible for a condition to develop this slowly (from a slight elevation eight months ago to being tripled by now)?
Ma'am,
Yes, those could certainly be symptoms, and in your situation, a consultation with a gastroenterologist is necessary.
And yes, it is entirely possible for a disease to progress this slowly and gradually. In fact, that is often how it works.
Since this is the second time we’ve seen these elevated aminotransferase levels, my understanding is that further investigation is required—regardless of how clean the ultrasound looks. We shouldn't forget that an ultrasound is a subjective tool; the results depend heavily on the technician's experience and what they happen to catch or miss.
Greetings. 🙂
Angela Wright said:I’ve been digging through some medical journals lately, and honestly, the consensus seems all over the place regarding iron supplementation. There's a lot of conflicting data out there.
If we’re talking about doing a KS before nine months—well, she was technically premature, though just on the borderline. Honestly, there weren't any issues with the baby at all. On the contrary, development is right on track; she's already sitting at 14 pounds.
So, I'm circling back to the same conclusion: I need to trust my gut and prioritize preventative care. It’s that maternal instinct kicking in again. Honestly, 3.5ml a day feels like a bit much for her stomach and digestive tract to handle.
Dear Ivanicapeca,
Even if a baby arrives just two weeks early, that slight head start for the world doesn't change the biological reality: their iron stores are lower than those of a full-term infant. It’s worth remembering that during those final days of pregnancy, the mother passes along her peak supply of iron and other essential nutrients. Because of that deficit, supplementing with iron is a perfectly reasonable precaution for these little ones.
Regarding the hemoglobin levels—that 109 figure you mentioned—you’re correct that it doesn't point to anemia. However, that isn't the full picture. A patient can still be iron-deficient even without being anemic. To get the real story, we have to look at the iron levels, UIBC, TIBC, and potentially ferritin to gauge those actual reserves.
He needs prophylaxis.
Preventative doses stay below therapeutic levels.
Which formulation are you using?