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Lab results - looking for opinions [PLEASE READ 1ST POST]

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Bryan Barnes2 Bryan Barnes2 Member
16 messages
joined Dec 2022
#1841 ·
Terry Williams19 said:If anyone could share their perspective on this lab result...
Result — Reference Interval
Platelets are at 136—just a bit below the standard range of 158 to 424.
MPV is sitting right at 10.4—which is essentially the upper limit of the 6.8 to 10.4 range—so it's technically within normal parameters, even if it's leaning toward the higher side.
Neutrophils are at 71.4—just barely within the standard range of 44 to 72. It's essentially like running a marathon and finishing just seconds before the timer hits zero—technically successful, though quite close to the limit.
White blood cells—specifically granulocytes—are essentially the frontline infantry of the immune system. Much like how a security detail protects a high-profile official, these cells move to intercept any perceived threats within the body.
White blood cells — 20.6 — 20-46.

Urine.
Red blood cells—roughly 2 to 3 times the standard level—compared against a range of 0 to 2.
White blood cell count—2-3—falls within the normal range of 0-5.
There is a significant presence of epithelial cells—quite a lot, actually.
It appears there is some sort of bacterial presence—much like a small, persistent leak in a basement that you only notice once it starts affecting the foundation.

Please specify once more—for the sake of clarity—the exact reason why the blood was drawn.
Based on the KCC guidelines—and looking at how things usually go—I’d suggest scheduling a follow-up KCC in about a month. From there, depending on what those results show—specifically if the platelet counts remain low—we should probably start a full workup to get to the bottom of the thrombocytopenia.

Brenda Stewart59 said:I could use some assistance, please...

Where in the city can I get the following tests done?

T3—one of the thyroid hormones—is essentially the body's primary metabolic driver—much like how fuel regulates an engine's pace.

Total IgE levels—think of it like a general alarm system for the body's immune response—can vary quite a bit depending on individual sensitivity.

ANA/ENA—these markers essentially function like a diagnostic compass—helping clinicians navigate the complexities of autoimmune patterns.

CH50, C3, C4, C1Q, and C1-INH—these are essentially the vital indicators for assessing the complement system—much like checking the various gauges on a dashboard to ensure the entire engine is running smoothly.

Serum protein electrophoresis and immunoelectrophoresis—think of them as the diagnostic blueprints used to map out the various proteins circulating in the bloodstream.


I called the labs one by one—trying to be thorough—but everyone there seems to be playing dumb. They insist that I show up with a physical referral in hand, yet when I actually arrive, I find they won't even perform certain tests. It’s quite frustrating—like being told you need a ticket for a show, only to get to the theater and realize they aren't even performing the main act. 😠

Mayo Clinic — Rebro T3
The T3 results will likely be on a separate instruction sheet—since we're looking at a radioisotope scan conducted through the Nuclear Medicine Institute.

Paul Ramirez59 said:Could someone please help me make sense of these lab results? I had them done because I started seeing flashes in my right eye—though an ophthalmologist has already checked me out, and everything looks fine, including the retinal exam.

Hematology results:

White blood cell count — 6.8 — within the standard range of 5.0 to 13.0.
Red blood cell count: 4.62 — within the standard range of 2.9 to 5.0.
Hemoglobin levels came back at 14.6—which is a bit higher than the standard range of 9.0 to 13.8. It’s like having slightly too much fuel in the tank—not necessarily a crisis, but certainly worth keeping an eye on.
Hematocrit is at 0.41—just slightly above the standard range of 0.32 to 0.40. It’s a minor deviation—much like a car running a few miles over the speed limit—but worth keeping an eye on.
My MCV came back at 89.4—which sits right on the edge of the normal range—so I am keeping a close eye on it. It is like being exactly one inch away from a finish line; technically you've reached it, but there isn't much breathing room left.
MCH — 31.6* — (Reference range: 24.3 - 29.2)
MCHC is at 35.4—just a hair above the standard range of 30.0 to 35.0—which is essentially like a car idling slightly higher than usual. It’s a minor deviation, really.
Platelet count: 227 — within the standard range of 150 to 450.
RDW—13.4—(normal range: 11.9 - 16.2). This falls squarely within the expected parameters—much like a steady heartbeat in a quiet room.
MPV — 8.6 — (Range: 6.9 - 11.3)

Clinical biochemistry—it really is the foundation of everything we do.

Serum glucose levels came back at 5.4—well within the standard range of 3.9 to 6.2.
Urea — 5.1 (Reference range: 2.5 - 7.5). Everything appears to be within the normal limits here—quite steady.
Creatinine 80 65 - 110
Cholesterol 5 < 5.3
Triglycerides 2.22* 0.4 - 1.9
AST 18 0 - 38
ALT 20 0 - 48

Urinalysis

Appearance Clear ref.in. clear
Color Yellow yellow
Protein trace opal neg
Glucose neg neg
Ketones neg neg
Bilirubin neg neg
Urobilinogen 1 - 16 1 - 16

Microscopic examination of urine sediment

Red blood cells 4 - 5* ref.i. 0 - 1
White blood cells 1 - 3* 0 - 5
Epithelial cells rare
Mucus Mass

NOTE: I went for a long bike ride the day before—resulting in some pretty intense leg soreness—if that could possibly be linked to these lab results...

I would appreciate any thoughts or advice.

These reference values seem quite strange.

How old are you? And which lab performed these tests?

If you are an adult male—and assuming hemoglobin units are expressed in g/dL rather than g/L—the upper limit should be north of 17 (or 170), not 13.8. The same logic applies to white blood cells (is the upper limit really 13?)

My suggestion is to definitely repeat the KCC—the biochemistry and urine results look fine.
redeagle75 redeagle75 Newcomer
9 messages
joined May 2012
#1842 ·
So, I went in for some blood work a few days ago.
It turns out a handful of my results are sitting just outside the standard reference ranges.

MCHC: 349 (normal up to 345)
Creatinine: 114 (normal up to 104)
Urate: 518 (normal up to 403)
Cholesterol: 6.8 (normal up to 5.0)
ALT: 49 (normal up to 48)
GGT: 60 (normal up to 55)
CRP: 6.9 (normal up to 5.0)
TSH: 4.78 (normal up to 4.20)

I'm a 31-year-old male.

My doctor has sent me off to get my thyroid hormones checked out and put me on some allopurinol in the meantime.
I was wondering if anyone here might have some insight or an opinion on this.
Thanks in advance.
Bryan Barnes2 Bryan Barnes2 Member
16 messages
joined Dec 2022
#1843 ·
redeagle75 said:I had some blood work done a few days ago.
The following results fell outside the standard reference ranges.

MCHC: 349 (normal up to 345)
Creatinine: 114 (normal up to 104)
Urate: 518 (normal up to 403)
Cholesterol: 6.8 (normal up to 5.0)
ALT: 49 (normal up to 48)
GGT: 60 (normal up to 55)
CRP: 6.9 (normal up to 5.0)
TSH: 4.78 (normal up to 4.20)

I am a 31-year-old male.

My doctor sent me for thyroid hormone testing and prescribed allopurinol.
I would appreciate your perspective on this.
Thank you in advance.

These findings—specifically the cholesterol, liver markers, and urate levels—could certainly align with a diagnosis of hypothyroidism—essentially an underactive thyroid.

Consequently, the physician's decision to investigate thyroid function (beyond just the TSH) is quite reasonable—though I wonder if there was a need to rush into allopurinol therapy—at least before the potential hypothyroidism is fully clarified.
Betty Hughes6 Betty Hughes6 Newcomer
5 messages
joined Mar 2012
#1844 ·
Sandra Vaughn50 said:Next time, tell us why you actually had the blood drawn.
Based on the CBC, I’d suggest repeating the CBC in a month. After that, depending on what we see—especially if platelets stay low—you should probably look into a full workup for thrombocytopenia.

Mayo Clinic
T3 will likely be on a separate referral since it involves a radioisotope scan through the Nuclear Medicine Institute.

These reference ranges are bizarre.

How old are you? Which lab handled these tests?

If you’re an adult male, and assuming hemoglobin is measured in g/dL rather than g/L, shouldn't the upper limit be above 17 (or 170) instead of 13.8? Same logic applies to white blood cells (upper limit 13?).

My advice: definitely repeat the CBC. Biochemistry and urinalysis look fine.


It was done in Ottawa, Canada.
Labs with these kinds of reference values show up here sometimes.

Can you help me interpret this if I break it down a bit? Why might Hematocrit and Hemoglobin be slightly elevated? Could it just be from working out hard the day before?

white blood cell 6.8.......................... ref.range 5.0 - 13.0.........................unit x10*9/L
red blood cell 4.62................................... 2.9 - 5.0.......................x10^12
Hemoglobin 14.6* ..............................9.0 - 13.8.....................g/l
Hematocrit 0.41* ...............................0.32 - 0.40....................1
MCV 89.4* .......................................73.8 - 89.4.....................fl
MCH 31.6* .......................................24.3 - 29.2.....................pg
MCHC 35.4* .....................................30.0 - 35.0.....................g/dl
Platelets 227 ..................................150 - 450
RDW 13.4 .........................................11.9 - 16.2
MPV 8.6 ............................................6.9 - 11.3
Bryan Barnes2 Bryan Barnes2 Member
16 messages
joined Dec 2022
#1845 ·
Paul Ramirez59 said:It’s regarding Canada—specifically Ottawa.
Labs like this show up with these reference ranges here.

Could someone interpret this if I break it down slightly? Why might the Hematocrit and Hemoglobin be marginally elevated—could it stem from physical activity the day before?

white blood cell 6.8.......................... ref. range 5.0 - 13.0.........................units x10*9/L
red blood cell 4.62................................... 2.9 - 5.0.......................x10 ? 12
Hemoglobin 14.6* ..............................9.0 - 13.8.....................g/l
Hematocrit 0.41* ...............................0.32 - 0.40....................1
MCV 89.4* .......................................73.8 - 89.4.....................fl
MCH 31.6* .......................................24.3 - 29.2.....................pg
MCHC 35.4* .....................................30.0 - 35.0.....................g/dl
Platelets 227 ..................................150 - 450
RDW 13.4 .........................................11.9 - 16.2
MPV 8.6 ............................................6.9 - 11.3


If someone presented me with these results in America, I would suspect those were reference values meant for a child aged 6 or 7. Since we are dealing with another country and a different lab, I will assume these values are indeed what they claim to be.

If the hematocrit and hemoglobin are truly slightly elevated, it is possible—under conditions of dehydration (following exercise and insufficient fluid intake)—that the blood is hemoconcentrated; essentially, due to reduced plasma volume, the hemoglobin appears falsely elevated, whereas it is actually just a relative increase at the expense of the plasma.

A previous workout could certainly trigger dehydration, leading to such a result. Theoretically, at least.

I would certainly recommend repeating the KCC in a month, ensuring proper hydration beforehand.
redeagle75 redeagle75 Newcomer
9 messages
joined May 2012
#1846 ·
Sandra Vaughn50 said:Those findings—the cholesterol levels, the liver lesion, the urates—they could honestly all be tied back to hypothyroidism if the thyroid isn't pulling its weight.

So, I think the doctor was totally justified in wanting to check those thyroid hormones alongside the TSH, though I can't help but wonder if there was a bit too much rush to jump straight onto allopurinol, at least before we really pin down whether that hypothyroidism is actually the culprit here.

My urate levels have been running high for about four years now, and I’ve already cycled through allopurinol once before. Usually, I’d take it for maybe six months, things would settle down into the normal range, and then my doctor would try to let me go off it, only for the urates to creep right back up a few months later. My thyroid levels were perfectly fine a year ago, so this is the first time they've spiked like this, and an ultrasound actually picked up a small nodule on the gland.
Bryan Barnes2 Bryan Barnes2 Member
16 messages
joined Dec 2022
#1847 ·
redeagle75 said:My uric acid levels have been elevated for about four years now—a persistent issue. I’ve actually been on allopurinol before. I would take it for roughly six months, which would bring my levels back down to a normal range, but once my doctor tried tapering me off, the uric acid would spike right back up after a few months. As for my thyroid, everything was fine until a year ago; this is the first time I've seen an elevation. An ultrasound also picked up a small nodule.

I wasn't aware you had already undergone treatment with allopurinol—that detail wasn't quite clear in your initial post.

So, the thyroid hormones are elevated?

With a TSH at 4.7, one would typically expect to see lower T4 and T3 levels—unless we are looking at secondary or central hyperthyroidism (though I note you mentioned a nodule).
But then again, medicine rarely follows a simple 2+2=4 logic, so...
redeagle75 redeagle75 Newcomer
9 messages
joined May 2012
#1848 ·
Sandra Vaughn50 said:I didn't realize you had already been on allopurinol before; looking back at your initial description, there wasn't really any hint of that.

So, are your thyroid hormones actually elevated?

With a TSH sitting at 4.7, I’d naturally expect to see low T4 and T3 levels. The only way that wouldn't be the case is if we're looking at secondary or central hyperthyroidism—though I noticed you mentioned a nodule on the thyroid.
But then again, in medicine, 2+2 rarely equals 4, so who knows...

They didn't bother checking my T3 or T4 levels during the general blood work they did. I'm heading back in tomorrow for some more testing, so hopefully, those will be included in the panel.
Brenda Stewart59 Brenda Stewart59 Newcomer
9 messages
joined Apr 2016
#1849 ·
Sandra Vaughn50 said:Mayo Clinic
The T3 scan will likely require its own separate referral since it involves a radioisotope scan through the Nuclear Medicine Institute.

Mayo Clinic doesn't actually perform T3 scans.
I went through the whole ordeal—getting properly scheduled for the test, confirming my appointment, finally showing up at the facility—only to find out they don't even offer it.

They’re telling me I need to send over referrals just to get scheduled for the other tests, too. I’m wondering if the process is identical to how they handle the T3.

I really don't have the patience to spend my day wandering from one lab to another just to check if they can run a specific test. And don't even bother calling; they won't give you any actual information over the phone.

So, I'm asking here—if anyone has firsthand experience, I'd appreciate it. If you're just guessing, please don't clutter this with misinformation.
restlessdriver restlessdriver Member
17 messages
joined May 2019
#1850 ·
restlessdriver said:Could someone take a look at these hormone levels? I'm in my early 20s. I've dealt with issues regarding my right testicle for most of my life; it's smaller than average and doesn't function fully—maybe only about 20-30% capacity. The left one is fine.

I just got my full results back.

TSH 4.15 (Ref: 0.465-4.68 mIU/L)
Progesterone 0.90 (Ref: 0.0-0.64 nmol/L)
Prolactin 218 (Ref: 73-407 mIU/L)
Testosterone 16.17 (Ref: 4.56-28.2 nmol/L, though some labs go up to 40)
FSH 3.29 (Ref: 0.9-12 mIU/mL)
LH 2.92 (Ref: 1.1-8.7 mIU/mL)
Estradiol 83 (Ref: 40-162 pmol/L)
Morning Cortisol 455.4 (Ref: 101.2-535.7 nmol/L)
Afternoon Cortisol 276.1 (Ref: 79-477.8 nmol/L)

Naturally, I'm feeling the effects through a lower libido than usual for my age, poor concentration, constant fatigue, and a need for more sleep than normal (napping in the afternoons). My overall vitality and energy levels have been pretty low lately, too. Muscle mass is also lacking, likely due to the low testosterone. I've already ruled out thyroid issues via previous tests...

What are your thoughts on treatment options?

Has nobody commented on these results yet, even though they've been posted for a month?
Bryan Barnes2 Bryan Barnes2 Member
16 messages
joined Dec 2022
#1851 ·
Brenda Stewart59 said:I simply don't have the bandwidth to wander from one clinic to another just to check if they offer a specific test—plus, you can't get any decent info over the phone.

At private labs, Rebro T3 tests cost about thirty or forty dollars—and you'll usually have the results the same day. It’s much better than wandering aimlessly from door to door and wasting your precious time.

restlessdriver said:Is anyone actually going to comment on these results? It's been a month since this was posted.

You've essentially self-diagnosed by claiming it's "likely due to low testosterone"—and then you ask for an opinion.

To be honest, I don't see a deficiency here—even considering your mention that some labs set their upper limit at 40... that would imply your level of 16-something might be seen as 25+ elsewhere.

Regardless of what you tell us, we aren't going to talk you out of your conclusion. You'll still feel it's too low—simply because you're young, in your prime, and all that.
I wouldn't be so blunt if I hadn't seen how you handle similar threads—defending your stance so fiercely against anyone with a different view.

Only an endocrinologist can prescribe therapy—I'm not sure what their take is on your situation.
And frankly, I hope you aren't considering any illegal routes to acquire steroids.

Have a pleasant day.
restlessdriver restlessdriver Member
17 messages
joined May 2019
#1852 ·
To be clear, I’m not looking for any illegal shortcuts. I’ve been referred to an endocrinologist because my urologist couldn't provide a definitive diagnosis or a path forward; he essentially said this falls outside his area of expertise.

Based on what I know so far, I’m in a tough spot. My levels are low for my age, which makes daily life a struggle, especially since I'm dealing with over twenty different symptoms that point to this issue. At the same time, the numbers aren't "critically" low yet because I'm still young and haven't hit that natural decline seen in older men—plus, the reference ranges used by labs cover everyone from young adults to seniors. I’m not sure what the endocrinologist will make of all this or how much they'll dig into it, so I’m hoping to get some perspective from other specialists who follow this topic...

A reading of 16.17 nmol/L converts to roughly 450 ng/dl, while the standard reference range is 300-1000 ng/dl. However, looking at clinical literature, the average testosterone for someone my age is typically around 700-800 ng/dl depending on the study. Given my specific symptoms and the issues I've had with my testes, it seems pretty clear where the problem lies.

According to the data, these types of values are more typical for men over 60...

Of course, I'm waiting on a specialist's opinion to confirm this and provide actual guidance.

Are you an endocrinologist yourself? Thanks for getting back to me...
restlessfox96 restlessfox96 Member
18 messages
joined Nov 2007
#1853 ·
Hi,

About five years ago, I went in seeing a doctor for sinus issues. Out of nowhere, he mentions my finger joints look swollen, suggesting some kind of inflammation. Honestly? I hadn't noticed a thing. No pain, no redness, nothing. Following his lead, I got tested, and a rheumatologist at the Mayo Clinic dismissed it as "nothing," labeling it as synovial thickening based on my blood work and X-rays. Fast forward five years: a colleague mentioned this could actually be RA, so I was advised to get a second opinion. This new specialist suggested an MRI, HLA typing, and fresh blood work. The blood tests and the MRI show zero signs of inflammation... but I have no clue how to read these HLA results. My follow-up is scheduled, but I’m losing patience. Can anyone make sense of these numbers?

Method: CDC (serological)

HLA-A
9 / ND

HLA-B
39 / ND

Method: PCR-SSO/SSP (molecular)

HLA-C*
NT / NT

HLA-DRB1*
03 / 16

HLA-DQB1*
NT / NT

Note M67
Nicole Patel2 Nicole Patel2 Newcomer
9 messages
joined Jan 2018
#1854 ·
I realize this might not be the ideal topic for a question, but I’d appreciate any insight.

I was scheduled for a pelvic MRI at a private clinic today. They required me to fast, clear my bowels using X-Prep, and use a tampon. However, when I arrived, they had messed up the scheduling—they double-booked me with another woman and couldn't see me. Since their next available slot isn't until mid-September, I went ahead and booked an appointment at a different clinic for tomorrow.

The second clinic told me that no preparation is necessary before the scan. Why would one place require prep while another doesn't? Should I go through the motions and do the preparation anyway? I don't want the image quality to suffer because I skipped it.

I have a significant endometrioma on my right ovary.
Karen Allen16 Karen Allen16 Newcomer
3 messages
joined Sep 2015
#1855 ·
I'd love to get some perspective here

beta HCG
Result <0.5

reference range <0.5-2.67

If I'm reading this correctly, it looks like there's no pregnancy on my end, right?
Betty Hughes6 Betty Hughes6 Newcomer
5 messages
joined Mar 2012
#1856 ·
Not sure which sub this belongs in, so I'll just drop it here. Following up on my last post where I mentioned my hemoglobin and hematocrit were running a bit high. Saw an internist this morning—EKG was fine, so they sent me for a chest X-ray and spirometry.
The report says: PA lung pattern shows increased hypopulmonary markings, but no active pathological changes visible in the lung parenchyma.
Heart contour shows slightly prominent aortic configuration (anyone know what that actually means?).
Spirometry results: FVC 87.5%, FEV1.0 91.5%—basically normal. Any thoughts?
Laura Booth4 Laura Booth4 Newcomer
1 message
joined Dec 2022
#1857 ·
Hi everyone. I picked up my lab results this past Monday because I haven't been feeling great lately—dealing with dizziness, headaches, and high blood pressure at 140/110.

Here are the results (I'll just list the elevated ones):
white blood cell 11.21 - normal up to 9.7
red blood cell 6.02 - normal up to 5.72
hemoglobin 181 - normal up to 175
mchc 349 - normal up to 348
neutrophil seg. granulocytes 8.05 - normal up to 6.49

glucose 6.24 - normal up to 6
urate 457.9 - normal up to 403
triglycerides 2.99 - normal below 1.7

Everything else looks fine.

The tests were done on Monday, five days after returning from a trip where I spent seven days walking around sightseeing every single day, plus going out most nights. I also wasn't eating much more than twice a day.
Is it possible that such an intense lifestyle over the last week caused these numbers?

My doctor is sending me for an abdominal ultrasound, and I have to admit, I'm a little nervous about it.
Bryan Barnes2 Bryan Barnes2 Member
16 messages
joined Dec 2022
#1858 ·
restlessdriver said:Are you an endocrinologist? Thanks for the response regardless.

I am not an endocrinologist—though I would certainly suggest scheduling a visit with one.

restlessfox96 said:Hi,

About five years ago, I saw a doctor regarding sinus issues. Unrelated to that, the doctor noticed swelling in my finger joints—which suggested inflammation. Personally, I hadn't even noticed it myself; there was no pain or redness. Following the doctor's lead, I went for tests, and a rheumatologist at the Mayo Clinic concluded it was "nothing significant," noting synovial thickening on the report. This was based on negative blood work and X-rays. Five years later, through a colleague, I learned there is a possibility this could actually be RA, so I was advised to see another specialist. That doctor recommended an MRI, HLA typing, and fresh blood work. The MRI and blood results show no signs of inflammation... but I can't quite make sense of the HLA results. I have an appointment scheduled to go over everything, but I'm a bit impatient and was wondering if anyone here could help interpret them.

Method: CDC (serological)

HLA-A
9 / ND

HLA-B
39 / ND

Method: PCR-SSO/SSP (molecular)

HLA-C*
NT / NT

HLA-DRB1*
03 / 16

HLA-DQB1*
NT / NT

Note M67

Based on what you've described, you don't meet the criteria for an RA diagnosis—the foundation of which is joint pain and redness (symptoms of inflamed synovium). As far as I can tell, your issue is purely cosmetic.
HLA testing doesn't confirm the presence of the disease, but rather a predisposition toward it—so... even if the test were positive (which isn't the case here, aside from a slightly elevated HLA DRB1 titer), without clinical symptoms, it wouldn't carry any weight in a diagnosis. It surprises me that anyone sent you for that specific test. I certainly wouldn't have.

Karen Allen16 said:beta HCG
Result
If I'm reading this correctly, it looks like there is no pregnancy?

That is how it appears to me as well.

Paul Ramirez59 said:What does "cardiac contour of an easily identifiable aortic configuration" actually mean?

It could suggest some structural changes in the heart due to long-term high blood pressure—though I don't know if that applies to you. On the other hand, this "easily identifiable" note might just be a cautious way for the radiologist to describe a perfectly normal finding.

I would recommend getting an echocardiogram.

Thomas Vaughn72 said:Hi, I picked up my results on Monday because I haven't been feeling great lately—mostly dizziness, headaches, and high blood pressure at 140/110.

Here are the results (I'll just list the elevated ones):
white blood cell 11.21 — normal up to 9.7
red blood cell 6.02 — normal up to 5.72
hemoglobin 181 — normal up to 175
mchc 349 — normal up to 348
neutrophilic segmented granulocytes 8.05 — normal up to 6.49

glucose 6.24 — normal up to 6
urate 457.9 — normal up to 403
triglycerides 2.99 — normal below 1.7

Everything else looks fine.

The tests were done on Monday, five days after returning from a trip where I spent seven days walking around sightseeing every day—and staying out late most nights. Plus, I wasn't eating much more than twice a day.
Is it possible that the more active lifestyle over the last few days caused these numbers?

My doctor is sending me for an abdominal ultrasound, which—to be honest—is making me a little nervous.

Based on what you've shared, there isn't any reason to panic quite yet.
I would suggest repeating the KCC test in two weeks—provided you stay properly hydrated beforehand.

An abdominal ultrasound? Well, it won't hurt—but how much clarity it actually provides remains to be seen.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#1859 ·
restlessfox96 said:I can't make sense of these HLA results.

Looking at the HLA typing, there aren't any obvious genetic markers for rheumatic diseases, aside from HLA drb1*03. That one does bump up the risk for systemic lupus erythematosus, but nothing major.

Regarding your symptoms—yeah, I agree with my colleague here. HLA typing isn't going to help clarify what you're going through, nor was it really necessary to run the test in the first place.
velvetmoose9 velvetmoose9 Active Member
163 messages
joined Apr 2020
#1860 ·
restlessfox96 said:Hey there,

So, about five years back, I went to see my doctor because my sinuses were acting up. Out of nowhere, during the visit, the doc mentioned that my finger joints looked swollen, which pointed toward some kind of inflammation. Honestly, I hadn't even noticed it myself—no pain, no redness, nothing. Just following the doctor's lead, I went in for some tests, and a rheumatologist over at the Mayo Clinic basically told me it was nothing to worry about, noting it as just synovial thickening in the report. He based that on my blood work and X-rays coming back clear. Fast forward five years, and a colleague mentions that there’s actually a chance this could be RA, so I was advised to get a second opinion. This new specialist suggested I go for an MRI and HLA typing, along with more blood work. The blood work and the MRI didn't show any signs of active inflammation... but I'm totally lost when it comes to interpreting these HLA results. I have a follow-up scheduled to go over everything, but I'm getting a little impatient and was wondering if anyone here might be able to make sense of these findings for me.


I'm leaning towards what the other folks here have been saying regarding whether HLA typing is even useful in these cases 👍

Looking through this whole forest of tests and data you've gathered, there are a few key things you haven't mentioned:

-How long those "swollen" joints have actually been looking like that
-The progression (meaning, are they always the same, or are they getting worse over time?)
-What you do for a living (like, if you're doing any kind of manual labor) and your environment (dealing with cold or sudden temp changes...)

Since you brought up the sinus issues—it's entirely possible you dealt with a strep infection (throat, sinuses, whatever) a while back that wasn't fully cleared out, leading to a sort of "reactive arthritis." In that scenario, those "swollen joints" would essentially be a lingering consequence of that infection.
But hey, that's just me speculating. 😉

Basically, maybe the first step should have been targeted testing to check for any lingering evidence of strep activity in your system. 🧐

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