Patrick Young2
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joined Jan 2019
(Google)
St. John's Wort drug interactions:
Taking St. John's Wort alongside certain medications can lower the concentration and effectiveness of drugs like digoxin (Lanoxin), warfarin (Coumadin), theophylline (Theo-24), and amitriptyline (Elavil).
You’ll also see a drop in plasma concentration and therapeutic impact when combined with cyclosporine, indinavir, carbamazepine (Tegretol), phenobarbital, estrogen, testosterone, and tamoxifen (Nolvadex)—which effectively reduces the efficacy of birth control pills.
While St. John's Wort is used for mild to moderate depression, you have to be careful if you're already on antidepressants like fluvoxamine (Avox), fluoxetine (Prozac), or sertraline (Zoloft). Furthermore, if you take migraine relief like sumatriptan (Imitrex) while using it, the effects of the St. John's Wort are significantly amplified. This can trigger nasty side effects, including cramps, sweating, headaches, and spikes in both blood pressure and body temperature.