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Genetically modified humans?

Started by stormylynx14 · · 👁 8 views · 42 replies

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Participants stormylynx14wearyowl29Richard Howard2Asilverdrifter46Rebecca Miller2Donna Hernandez10Elizabeth Miller8Nicole Jameshollowtrucker77Michelle Alvarez8William Scott40Matthew Doyle73swiftcobra15steelstag4Nicole BakerRobin Rodriguez5nimbledriverAaron Foster2Austin Grant3
stormylynx14 stormylynx14 Active MemberOP
69 messages
joined Dec 2005
#41 ·
Aganor said:Everything mentioned above sounds great in theory, but reality is messy. Even standard gene therapy hasn't lived up to the hype—not for the scientists, not for the doctors, and certainly not for the patients, particularly cancer patients who were promised miracles. It isn't working out quite as planned.[/B]

We are barely scratching the surface. We know the basics, and mapping individual gene functions can drag on forever, but the roadmap is there.
Aganor said:However, when we talk about germline therapy or modifying the genome of embryos and fetuses, the landscape changes entirely.
So, let me ask you a few questions. Once you answer, we can see if you actually grasp what you're talking about.
[/B]

Exactly. Fetal modification is controversial, which is precisely why I want to discuss it.
Regarding point 1: This is a broad debate. How this applies to the American public and its long-term consequences deserves serious scrutiny.
Regarding point 2: Using this on human embryos is only an option once we've mastered the mechanisms in other species. Risks exist regardless; we simply apply the same ethical standards used in all human research. This isn't a new dilemma, nor has it ever been a reason to halt progress.
Regarding point 3: Certain therapies should be covered by health insurance (if we find modifications for diabetes, cancer, etc.), especially since the resulting illnesses are matters of social welfare. Investing early in life saves massive amounts of money down the road. Other tweaks, like eye color or intelligence, shouldn't be subsidized by the public.
Regarding point 4: Genetic inequality already exists. A parent's desire to give their child the best possible start is legitimate. It’s nothing new; kids from wealthy families in cities like New York or Los Angeles already have a head start without any genetic help. Let's not descend into anecdotal arguments about some millionaire's kid struggling with addiction.
Regarding point 5: What happens during recombination when different genetic info meets at conception? Mutations—benign or otherwise? Only the method changes; the outcome remains the same. There is a risk of introducing new defects, but that shouldn't be a reason to ban genetic modification entirely. The potential benefits are too significant.
Regarding point 6: People ask how to prevent abuse. Yet, we didn't ban blunt force trauma. Ethics usually dictate how we use a tool, rather than banning the tool itself.
nimbledriver nimbledriver Newcomer
5 messages
joined Jan 2003
#42 ·
nimbledriver says:
We’re just scratching the surface here. We know the basics, sure, but mapping out individual gene functions can drag on forever. Still, the roadmap is set.
__________________________________________________ __

Oh, so you think you're an expert now? Is that it?
Look, I already told you: Gene Therapy hasn't lived up to the hype.
Even though this type of treatment only fixes defects for the specific patient being treated—meaning it stays with them for life and isn't passed down to their kids—it still falls short.

The success we've seen over ten years of applying and refining these methods is frankly underwhelming. Sure, you can point to a few wins with SCID or certain combined immunodeficiencies as proof of concept, but that's just marketing. Real, widespread success? It’s non-existent.
The issue is simple: we completely underestimated how complex genetic regulation actually is.
The massive technical hurdle remains the stable integration of foreign genes into the target cells and ensuring those genes actually keep functioning long-term.

Even when they actually manage to transfer the gene, it often goes dormant, or the gene simply fails to recombine during cell division!
There's also a massive danger lurking in both Gene Therapy and stem cell treatments: the "slippery slope" leading straight to Gene Therapy via germline modification.
And let me be clear: these risks are enormous. We cannot afford to brush them aside.
This isn't just about medical hurdles. We are looking at massive moral, ethical, social, and legal minefields. Every governing body needs to weigh in and establish strict directives on what is permissible and exactly why certain things are strictly off-limits.
Best regards,
stormylynx14 stormylynx14 Active MemberOP
69 messages
joined Dec 2005
#43 ·
Exactly. Right now, the technology isn't ready for prime time. We need to iron out the issues you mentioned through animal testing before we even consider humans. That doesn't mean we shouldn't be debating the ethics of genetic modification today.

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