swiftgull37 said:Dear Nicholas Myers,
I was wondering if I should be concerned. For about a year now, I've been doing regular CBC tests due to iron deficiency. So far, everything else related to that hasn't been worrying. However, in this week's results, my platelets are 153 (range 158-424). On its own, that wouldn't bother me—even though it's below the minimum—except that they have dropped drastically from my last result in August, where platelets were 200. In March and May, they were 170, and back in late December 2015, they were 207, while in late November 2015, they were 276.
Is it normal for them to drop this much, or rather, to be in a constant decline?
Ma'am,
Thrombocytopenia is defined as a platelet count below 150x10*9/L, so strictly speaking, you don't have low platelets yet.
On the other hand, as you mentioned, you have iron-deficiency anemia. Platelet counts and erythrocyte counts can be linked. Typically, iron-deficiency anemia is associated with an increased platelet count, or thrombocytosis, though cases with low platelets have been described, albeit extremely rarely.
Have you identified the cause of the anemia? Heavy menstrual bleeding? GI bleeding?
Have you had a peripheral blood smear done?
Furthermore, are you experiencing any symptoms?
Elevated Factor VIII levels can appear during inflammation, infection, pregnancy, or when taking oral contraceptives, but they can also be congenital, occurring without a specific underlying cause.
Aside from a potential link to the anemia (the cause of which you haven't specified), the drop in platelets could be entirely independent of your anemia—a separate issue altogether.
The most common cause of mild, isolated thrombocytopenia in adults is immune thrombocytopenia. Usually, in these instances, routine follow-ups include a peripheral blood smear and testing for HIV and hepatitis C, with other tests performed as indicated.
Since it isn't clear from your inquiry what symptoms you are having or what is driving the iron-deficiency anemia, I cannot say for certain whether you need further diagnostic workup or if simply monitoring the platelet count—perhaps at monthly intervals—would suffice.