restlessstag71 said:I went ahead and got that HLA typing done as well. I came across some information suggesting that HLA-B35 is linked to rheumatoid diseases.
The HLA-B35 marker is linked to a specific form of enteropathic arthritis—often referred to as Type 1. It manifests as joint inflammation in patients dealing with inflammatory bowel diseases, such as ulcerative colitis or Crohn’s disease, along with other intestinal conditions.
If you're dealing with those specific symptoms, the fact that we haven't confirmed an HLA-B27 status is a much bigger deal. It changes the whole equation.
Then I realized my ANA test could come back positive, which led me straight to the conclusion that I’m dealing with undifferentiated spondyloarthritis. Naturally, I need to sit down with my doctor to hash all this out and schedule some follow-up testing.
ANA is relevant when looking at systemic connective tissue diseases, not undifferentiated spondyloarthropathy. This finding doesn't really support that specific diagnosis.
restlessstag71 said:If you have a moment, I’d appreciate it if you could answer one more quick question for me.
I was doing some digging and stumbled upon a link between HLA drb1*01 and asthma. Given my history of severe allergies and the recent onset of asthma symptoms, this feels like a significant connection.
HLA drb1*01 shows up more frequently in people dealing with asthma and high serum IgE levels. But when you look at joint issues, it’s tied to rheumatoid arthritis—essentially acting as a marker for an increased risk of developing the disease.
Regarding that ANA result—you mentioned it came back positive at a low titer. Could that be linked to allergies or asthma?
The data indicates that patients suffering from asthma show a higher incidence of ANA compared to healthy individuals.
restlessstag71 said:Can someone please help me make sense of this? I’ve detailed my back issues in previous posts, but I finally went in for some testing today. Here are the results:
SE 8 (4-24)
CRP is at 0.4. Normal range is 0.1 to 5.0. Low, steady.
RF Urea: 227 (Range: 134–337)
I’ve been looking into arthritis. My RF came back at div>
Inflammatory markers look normal, and the RF is negative. Based on the symptoms you described, those results don't really point toward rheumatoid arthritis. That said, even if we were considering RA, a negative RF doesn't rule it out—about 20% of patients are seronegative.
Your symptoms are quite varied. Some of what you’ve noted could align with various rheumatic conditions. However, I noticed you’re approaching this in reverse order: instead of seeing a rheumatologist first and then getting targeted testing, you're running subspecialty tests and trying to piece together a diagnosis from the data.
To diagnose a rheumatic disease, a patient has to meet specific clinical criteria. Lab work is just one piece of that puzzle; without a proper physical examination, a diagnosis is impossible.
If we ran every possible immunological and rheumatological test on everyone in this room, many of us would show at least one positive result. That wouldn't mean we all have autoimmune diseases.
The lab results you've obtained must always be interpreted alongside the actual clinical picture.