Emily Ortiz27 said:Respectfully, the saga continues.
While waiting for the ophthalmology results, the endocrine panel came back. Here is the data:
Left hand X-ray—bone age matches that of a six-month-old boy (the scan was performed at 12.5 months old).
E 4.18 [x0012/L], Hbg 106 [g/L], Hct 0.326 [L/L], MCV 78.0 [fL], MCH 25.4 [pg], MCHC 325 [g/L], RDW 15.7 [%], Trc 327 [x109/L], MPV 10.2 [f/L], Lkc 15.9 [x109/L], NEUaps 6.48 [x109/L], LIMFOaps 7.66 [x109/L], MONOaps 0.75 [x109/L], EOaps 0.93 [x109/L], BAZOaps 0.08 [x109/L], NEUTRO% 40.8 [rel%], LIMFO% 48.2 [rel%], MONO% 4.7 [rel%], EO% 5.8 [rel%], BAZO% 0.5 [rel%], GLU (s) 4.5 [mmol/L], UREJA 4.9 [mmol/L], Na137 [mmol/L], K (s) 4.7 [mmol/L], Cl 103 [mmol/L], Ca 2.45 [mmol/L], P 1.85 [mmol/L], TBIL 4 [umol/L], AST 63 [U/L], ALT 27 [U/L], ALP 267 [U/L], GGT 9 [U/L], ACTH 5.32 [pmol/L], pH-kk 7.376, pCO2 - kk 4.41 [kPa], pO2 - kk 8.6 [kPa], Akt. HCO3 -k 18.9 [mmol/L], tCO2 kk 20.0 [mmol/L], SBE - kk 5.2 [mmol/L], SO2 - 92 [%], FT4 15.40 [pmol/L], TSH 3.33 [mIU/L], LHL], FSH 0.683 [IU/L], PRL 638.3 [mIU/L], CORT 596.2 [nmol/L], IgE 22.7 [kIU/L]
HGH 1 6.48 [mIU/L], HGH 2 5.19 [mIU/L], HGH 3 3.75 [mUI/L], HGH 4 16.70 [mIU/L], HGH 5 16.60 [mIU/L], HGH 6 17.6 [mUI/L], d1L], e1L], e5L], fx5 negative, t3L], antitTGmL], IGF-1 2.0 [nmol/L], IGFBP-3 55 [nmol/L]
The diagnosis is growth retardation, classified as Type 2. They noted we should return for a follow-up in a year. Growth hormone deficiency, celiac disease, hypothyroidism, and chronic illnesses have been ruled out.
That bone age stands out to me. How much deviation is considered acceptable for this age group? I don't have the reference ranges for the other values, so I can't tell if anything else is off.
Thanks in advance for the help.
Looking at the standard lab work, there is a slight elevation in eosinophils, though it’s a significant improvement over the last set; it's only mildly high now. It will likely normalize gradually. There is also a minor elevation in absolute lymphocyte count. It's hard to say what significance those carry, but the trend toward improvement is good.
Allergy testing results are normal.
Aside from the hormones, I don't see major abnormalities, except for a somewhat low oxygen saturation. Since you mentioned sweat chloride tests were done previously, has the child had any respiratory issues?
Regarding the hormone levels, they seem within range, but for growth hormone and IGF-1, one really needs to know the specific laboratory's reference values and testing methodology to determine if they are truly abnormal.
Bone age should ideally align with chronological age. Since it doesn't, biological maturity is lagging behind his actual age; essentially, he is about 6.5 months behind in development.
There are countless reasons why growth might be delayed. When no clear cause is found, it's labeled idiopathic short stature. If you are feeling uncertain, my advice would be to seek a second opinion at Mayo Clinic; they have extensive experience with these cases and can likely offer more guidance.