boldridge17 said:Hi everyone!
I’m looking for some perspective here..
For the last five years, every time I get bloodwork done, my RDW and MCHC levels fall outside the normal range. My doctor tells me there's no reason to worry at all—that I'm healthy, though my lymphatic system gives me a bit of trouble.
Here is my diagnosis: external lymphostasis, lower right.
Lymphoscintigraphy showed: reduction of the right iliac pelvic lymph node group and reduced structure with lymph retention in the distal part of the right lower leg.
COULD SOMEONE EXPLAIN THIS IN PLAIN ENGLISH? From what they told me, I have clogged lymph nodes—essentially like veins—so my lymph isn't performing its job properly.
Basically, whenever I get blood drawn, my RDW is low. A normal range is 14.6–16.5, but mine sits between 12.5 and 13.1.
My MCHC is always elevated; normal is 320–345, while mine is consistently 346–350.
In my most recent results, my monocytes were high too... normal is 2–12, and mine was 13.4.
Next week, I’m heading in for more tests: CRP, FBG, CK, LD, ESP, and RF.
Thanks in advance.
Hello,
You haven't quite framed the question you want answered.
Regarding the RDW and MCHC parameters, they should always be viewed
alongside hemoglobin, hematocrit, red blood cell count, and MCV.
Among the erythrocyte indices (MCV, MCH, MCHC), MCV carries the most weight. The significance of MCH and MCHC is much lower, and their measurement isn't as reliable. Consequently, we don't assign much clinical importance to isolated minor deviations in MCH or MCHC, provided that the MCV, red blood cell count, and hemoglobin are all within normal limits.
RDW is an important indicator when anemia is present. If the red blood cell count, hemoglobin, and MCV are all normal, then a slightly low RDW value doesn't hold much clinical significance; it simply indicates that the red blood cells are uniform in size and there isn't a major variation among them.
I am assuming your red blood cell count (E), hemoglobin (Hgb), hematocrit (Hct), and MCV are normal. If they are, your doctor is right—there is no cause for concern.
Furthermore, the monocyte percentage is of little consequence if we don't know the total white blood cell (WBC) count, so the clinical relevance of that specific result is questionable.
It isn't clear why you are linking lymphedema or lymphatic stasis to RDW and MCHC findings, as there is no connection between the two.
Elizabeth Davis said:I'm 23 years old. I haven't had a period naturally for about four years now. My reproductive organs are healthy.
I don't have any physical illnesses.
I take antidepressants and an anti-epileptic, but the amenorrhea started long before I began taking those medications.
I'm seeing an endocrinologist next week, but I would love to hear some thoughts if possible before then. Thanks in advance.
Image 1
image 2
image 3
Dear Madam,
It is highly probable that you will undergo further hormone testing, including additional markers and perhaps an MRI of the pituitary gland.
Your results show low LH and FSH levels, along with low Estradiol. This specific pattern—combined with what I assume is secondary amenorrhea (where periods were regular but have since stopped)—points toward hypogonadotropic hypogonadism. There are numerous potential causes for this. First, we must determine if you have been using hormonal medications, such as birth control pills, as these can suppress LH and FSH levels. If those aren't in the picture, then hypogonadotropic hypogonadism becomes a primary consideration.
The list of potential triggers for this imbalance is extensive. Very often—though certainly not exclusively—high stress levels, psychological factors, low body weight, or eating disorders can cause these shifts. However, we need a full view of all pituitary hormones before drawing conclusions. The differential diagnosis is quite broad, meaning we have to systematically rule out various conditions and illnesses.
Additionally, your androstenedione is elevated. Interestingly, this isn't accompanied by a rise in DHEA-S, which is typically expected. This suggests that while the pituitary is a focus, we should also look toward the adrenal glands, especially since you mentioned your gynecological exam was normal.
In any case, expect a series of follow-up tests and a consultation with an endocrinologist. (For context, Sister Rosalia Kaslik Medical Center is the specialized referral hub here, though the Chicago University Hospital Center is also excellent).