bluescout3 said:Thanks so much for getting back to me! 👍
I happened to stumble upon an interview online with one of the most prominent psychiatrists working today, Karl Deisseroth.
He’s an author as well, and in one of his books, he explores the evolutionary link between malaria resistance and the life-threatening genetic disorder known as sickle cell anemia. For a child to actually be born with sickle cell disease, they have to inherit the sickle cell gene from both parents. However, if someone carries just a single copy, they actually benefit from a "sharp evolutionary advantage" by being resistant to deadly malaria. "These mutations are sharp measures, rapid hacks that continue to fight against the agonizingly slow arena of natural selection," he writes.
But even though we are standing on a "threshold" in our understanding of mental illness, grasping its evolutionary role still lags far behind our understanding of physical diseases. “With the sickle cell trait, those who receive the compensation aren't necessarily the ones who suffer. Is it also true for mental illnesses—that there is some benefit intended only for close relatives? Or, perhaps, could it be that those with mental illnesses gain a direct benefit—at some point, in some way?” he asks.
Best, bluescout3
Emily Hu, when it comes to discussing the genetics of mental illness, or schizophrenia specifically, it’s such a tricky subject to navigate. I honestly don't think schizophrenia will ever be completely wiped out because it affects so many people. Even if we were to go down a dark path—which would essentially border on fascism—and forbid anyone with schizophrenia from having children, it wouldn't work, simply because so many people carry the gene without ever actually developing the condition.
Schizophrenia feels a bit different from something like sickle cell anemia, mostly because I suspect the latter is purely genetic, whereas schizophrenia isn't quite that straightforward.
You see cases where both parents are ill and the children end up being affected about 50% of the time. You also see examples with identical twins—who are genetically identical and raised in virtually the same environment—where only about 50% of the time do both suffer; otherwise, it's just one of them.
That said, the heavy influence of genetics is proven by the fact that if only one parent is ill, the probability of the child developing it drops from 50% down to just 12%.
As for what else triggers the illness besides genes, we don't officially know. Whether it's a specific environmental trigger, a trauma experienced during early childhood, or something else entirely, we can only speculate. That's why the best solutions right now involve medication—either discovering new types or finding the perfect combination of existing ones. Of course, psychotherapy, especially cognitive behavioral therapy with a skilled therapist, is vital too. Unfortunately, I'm not in a position to afford regular therapy myself, and since my check-ups only happen once every two months, I find myself writing here on the forum quite a lot. 😁 😁