velvetmoose9 said:Now you’ve actually got me curious... Alright, fine, draw me a diagram (or drop a link) showing how liver glycogen is made up of—according to you—fructose molecules instead of glucose... And which "cop" (enzyme) is blocking the creation of liver glycogen (which is about 10% of an average healthy person's total liver mass) from glucose just to "fill up liver glycogen (exclusively) with fructose"... Is it glycogenin, glycogen synthase, some "branching enzyme," or UDP-glucose pyrophosphorylase? Maybe you can explain this to a guy who gets nothing but 5%, 10%, or 20% glucose IV drips and has zero liver glycogen. Or wait, maybe he *does* have some, depending on how much glucose he takes in?... Give me some clarity here. Also, explain how massive amounts of fructose affect LDL levels and triglycerides (and how those impact cardiovascular and cerebrovascular incidents) and the rise in abdominal fat ("it's stupid to avoid it" ?????? )... So, in your view, someone who doesn't consume fructose has a liver that's 10% lighter than someone who does? These questions are simple, my ignorance is huge, and since you're such a nutrition expert, it shouldn't be hard to clear this up for me... I'm not questioning that fructose is a useful sugar for the body, but give me some references or an explanation for these claims...
First off, my bad for misstating the fact that liver glycogen is filled exclusively by fructose intake. That's not true. However, it's an undeniable fact that it gets filled way more effectively that way. According to this
study, the amount of synthesized glycogen was four times higher after consuming fructose compared to glucose.
Also, please stop twisting my words—I never once said that liver glycogen is actually composed of fructose molecules.
To clarify:
Fructose also breaks down into pyruvate during glycolysis. It's converted into fructose-6-phosphate via hexokinase (an intermediate in glycolysis), or it's converted into fructose-1-phosphate, which then splits into dihydroxyacetone phosphate and glyceraldehyde. From there, glyceraldehyde is phosphorylated into glyceraldehyde-3-phosphate, another glycolytic intermediate.
As for the specific mechanism where fructose refills liver glycogen better than glucose, I'll admit I don't know anything beyond the fact that the liver converts ingested fructose into glucose.🤷
I actually just stumbled upon this
patent where everything is laid out beautifully, and honestly, I learned something new from it.
Their ideal drink for replenishing glycogen (both muscle and liver) contains glucose, fructose, and galactose. Besides, Jeukendrup and Jentjens are basically the authorities in this field, so they're probably worth trusting.
The supposed negative health effects of fructose come from massive doses used in studies meant to "prove" it's bad—or even worse, studies done on rats (I remember one where rats were fed 60% of their daily energy from fructose. Helloooo?). Now tell me, how much are you actually taking in your post-workout meal if you're eating sucrose? 15g? You definitely take in more throughout the day from fruit, and lo and behold, fruit is recommended in large quantities. Hm...
Bottom line: the fear surrounding fructose is totally unjustified, and it's a legitimate part of a proper diet.