Olivia Castillo562 said:Hi, this is my first time posting on the health forum, so I hope I'm doing this right.
Age: 28, not pregnant 🙂 non-smoker, using oral contraceptives
Reason for testing: I get sick with strep quite often. Had my tonsils out when I was 16. Since then, infections have been less frequent, but last year I was getting hit hard. First time in August, second time in October—they actually tried to admit me to infectious disease back then, but I refused. Then it happened again in December. In September, I also dealt with severe hives after eating raspberries (twice, even though I’ve never had an allergy before), and this year my arms have broken out multiple times after touching leaves or strawberries. My knees have been aching too, varying in intensity. I felt completely exhausted through November and December. So, I started the workup.
Tests done before seeing the immunologist at Mayo Clinic: I had two separate throat swabs; both times, I tested positive for two out of three days. Thyroid levels look fine, all within range. Negative for Waaler-Rose and latex. CBC values are all within normal limits.
Fibrinogen 4.4 (reference range 1.5 - 4),
last AST-O 678 IU/ml (reference < 200),
last CRP 17.45 mg/l (reference < 6),
protein electrophoresis: elevated alpha 2 at 11.1 (normal 6-10) and beta at 15.5 (normal 8-13).
My primary doctor referred me to immunology at Mayo Clinic, where they recommended: ANA, IEF, anti-thyroglobulin and anti-microsomal antibodies, AST, CT telethermography, autologous serum test, skin prick tests for inhalation allergens, total IgE, C3 and C4, and an ultrasound of the arm and leg arteries.
I’ve completed: the skin prick tests and the autologous serum test; both were negative.
Then the anti-thyroglobulin and anti-microsomal antibodies:

ANA, IEF, total IgE, C3 and C4
I haven't done the rest yet because the wait for the CT telethermography is incredibly long, so I'm in no rush to get the artery ultrasound or the AST done.
I would appreciate some insight on these results, as my doctor is away on vacation for a while and my follow-up with the immunologist isn't until November 6th.
Thanks in advance 🙂
Hello,
As things stand, these results seem fairly disconnected and a bit confusing without a deeper discussion regarding all your symptoms and their exact timeline (for instance, the relationship between joint pain and any potential sore throats).
To start, the elevated AST-O (regardless of the fact that your tonsils were removed) indicates contact with strep in the recent past (relative to when the sample was taken). However, this single value doesn't tell us much; it is vital to monitor the titer dynamics—essentially how that AST-O value changes over time—to determine what is actually happening.
Unfortunately, strep can hide in places other than the tonsils (like the nasopharynx, ears, or skin) and continue causing issues.
The CRP, acting as an indicator of inflammation, is slightly elevated. For interpretation, it is crucial to know if you were experiencing any symptoms at the moment the sample was drawn, as even a common virus could produce a result like this.
While they might seem unrelated, there could be a link between elevated anti-Tg antibodies and hives (though I doubt it applies to your specific case), as well as elevated IgA levels.
Essentially, a positive anti-Tg result means your body is producing antibodies that can target the thyroid and disrupt its function. Since your TSH is within the normal range, medication isn't strictly necessary right now, but you’ll need periodic thyroid hormone monitoring.
Furthermore, a positive anti-Tg finding can sometimes trigger false elevations in IgA levels—largely due to the specific testing methodology used, which is a bit too technical for this forum.
That said, high IgA can also be interpreted as the body reacting to mucosal irritation, such as chronic respiratory infections.
Chronic autoimmune urticaria can indeed be linked to an autoimmune thyroid condition.
I see an autologous serum test was performed, which is useful for diagnosing chronic hives. However, based on what you've described, I'm not convinced we're looking at chronic urticaria. We typically reserve that diagnosis for hives lasting longer than six weeks, whereas it sounds like you experienced two acute episodes.
The LE cell test has largely been phased out in favor of other diagnostic tools for systemic lupus erythematosus, most notably the ANA test.
Your negative ANA result, according to the report, strongly argues against a diagnosis of systemic lupus erythematosus.
A negative rheumatoid factor doesn't completely rule out rheumatoid arthritis, though the symptoms you mentioned don't particularly point in that direction.
Ultimately, it is difficult to provide a definitive commentary on these results without seeing the patient in person and having a full grasp of the clinical picture.
For now, the findings suggest a recent contact with Streptococcus, a predisposition toward mucosal infections (like recurring respiratory issues), and the possibility of an emerging autoimmune thyroid disease—though this shouldn't impact your clinical symptoms or cause any actual distress.
Best regards. 🙂