Charles Mitchell79 said:I saw someone mentioning Zorac gel on this forum, so I decided to ask you guys something. Can you tell me if I should buy this cream? I noticed it says you shouldn't apply it to the face, and I have acne iuvenilis (which isn't psoriasis) just on my face.
So, here’s the lowdown on ZORAC—it falls into the Tazarotene category.
Tazarotene
Basically, Tazarotene is an esterified retinoid that breaks down in your skin into its active form, tazarotene acid. That’s actually the only known metabolite of tazarotene that carries any real retinoid activity. This acid specifically works by regulating gene expression—basically modulating cell proliferation, skin tissue hyperplasia, and how skin cells differentiate. Now, don't get too technical on me, because the exact mechanism of how tazarotene acid treats psoriasis isn't fully understood yet. What we *do* see is that patients improve as their skin starts looking normal again, which happens alongside a reduction in inflammatory markers like ICAM-1 and HLA-DR, plus it helps with epidermal hyperplasia and those weird abnormalities in skin cell differentiation—you know, things like keratinocyte transglutaminases, involucrin, and keratin.
You’ll usually find Tazarotene in gels or creams used to treat mild to moderate psoriasis that doesn't cover more than 10% of your body. Most people start with a 0.05% concentration and then move up to 0.1% if they need more punch.
A quick heads-up: you definitely shouldn't use Tazarotene products if you're pregnant or breastfeeding because of the potential risk of birth defects (teratogenic effects on the fetus). Also, it’s a no-go for pustular or exfoliative psoriasis, and you shouldn't put it on hairy areas of the skin or in skin folds.
You also have to be careful using Tazarotene on skin that's already damaged or inflamed from psoriasis, since it can cause irritation. And please—keep it away from your eyes. Also, once you've applied a Tazarotene product, your skin becomes extra sensitive, so don't go out into direct sunlight or hit up a tanning bed.
The most common side effects? Itching, a burning sensation, redness, irritation, peeling, contact dermatitis, skin pain, and—believe it or not—sometimes even a temporary worsening of the psoriasis itself.
Registered in the US since 2006: Zorac (Belupo)