Kyle Nelson2 said:I’d pose a general question: what does it mean when anti TPO is within normal limits (0-34), but anti TG is elevated (significantly above 115)?
Elevated anti-thyroglobulin levels can be linked to various conditions, ranging from autoimmune thyroid diseases and thyroid tumors to other autoimmune issues like rheumatoid arthritis, chronic urticaria, Sjögren's syndrome, SLE, or autoimmune hemolytic anemia. They also show up in a small number of healthy individuals, though the values aren't typically that high there. You might also see them in pregnant women or people with a family history of autoimmune thyroid disease.
Anti-thyroglobulin isn't a specific marker. A high reading alone isn't enough to confirm any of those diagnoses; it has to be looked at alongside other parameters. Some even argue that an elevated anti-thyroglobulin level without anti TPO shouldn't be used as sufficient grounds for an autoimmune thyroid diagnosis if suspicion exists.
More info here: http://emedicine.medscape.com/articl...erview#showall
slyfox9 said:Does anyone know what these values mean?
HLA-A 02/--
HLA-B 18/44
HLA-C NT/NT
HLA-DRB1 04/11
HLA-DQB1 NT/NT
Thanks in advance.
Best regards.
The core concept behind this testing is that certain HLA antigens appear more frequently in people with specific diseases than in the healthy population.
Essentially, the presence of certain antigens is tied to a slightly higher risk of developing a particular condition. This doesn't mean that having the antigen guarantees you'll get sick. Similarly, someone can develop the disease without having that specific antigen.
Regarding your specific results, I see you have HLA-DRB1*04, which can be associated with rheumatoid arthritis.
However, it isn't quite as straightforward as it looks. Within HLA-DR4, there are actually over 30 subtypes (labeled HLA-DRB1*0401 through *0433), and only some of them are linked to rheumatoid arthritis—most notably DRB1*0401 and DRB1*0404.
It is thought that people carrying these specific subtypes face roughly four times the risk compared to the rest of the population. For instance, about 60% of rheumatoid arthritis patients (in America) carry one of these HLA-DR4 subtypes, and if you factor in all the subtypes, that percentage can climb as high as 80%.
That said, your report doesn't provide that level of granular detail because the typing wasn't performed that way.
For more on the link between HLA and specific diseases, check this out: http://www.ncbi.nlm.nih.gov/pmc/arti...7156/table/T1/