Lab results - looking for opinions [PLEASE READ 1ST POST]

Maria Fisher46 said:The results suggest a possible genetic predisposition for rheumatoid arthritis.

I’ve covered this more in previous posts within this thread:

Are you experiencing any eye issues? (There's an H35 note, which is the ICD-10 code for "other retinal diseases").

Yeah, they're treating me under that diagnosis. That's how the workup started. It all kicked off when I ended up in the ER—for about five days prior, I had this constant sensation like something was stuck in my eye, even though I couldn't see anything. It was incredibly irritating. Before that, for maybe two or three months, my eyes were constantly red, and there were moments where my vision would just blur out, like looking through frosted glass. An ophthalmologist finally did a full exam and actually listened to everything my GP has been ignoring for the last couple of years: joint and bone pain, terrible abdominal pain (especially after eating), chronic fatigue, feeling cold, strange itching, and acne that's persisted for about 15 years despite every treatment imaginable. I really do have a whole string of symptoms. My eyes are still dry and red, so I'm using drops to manage it, and that "something in my eye" feeling has faded about 90% thanks to the eye drops. I still occasionally see a tiny black spot in my field of vision. I had an MRI of my brain; they found a cyst and some other changes... I'm taking those results to a neurologist this week. Thanks. I was curious about this. I thought maybe they'd find something regarding my stomach pains too, but maybe they weren't looking for that or it isn't part of this specific screening... Thanks again, you've been a huge help!

Could anyone provide some insight regarding these lab results for my sister? There is a suspicion of celiac disease.
Thanks 🙂

Total IgE 591 (kU/L, ref. range up to 87)
IgM 2.44 (g/L, ref. range 0.4-2.3)
IgG and IgA levels are within the normal range.

Chris Kim63 said:I thought they might have looked into those abdominal pains of mine as well, but maybe that wasn't on their radar or isn't part of the scope here. Thanks again—you've been a huge help!

No, the point of these searches isn't to analyze individual symptoms. It’s simply to check for genetic predispositions to certain diseases—specifically those that are already well-documented and established. I included the link to the chart so you can see exactly which conditions are covered. For now, the list remains relatively modest.

quietfox384 said:Could someone take a look at these lab results from my nurse? There's a suspicion of celiac disease.
Thanks. 🙂

total IgE. Immunoglobulin E. It’s the body’s primary trigger for allergic reactions—think of it as the biological alarm system that overreacts to harmless substances. When the immune system misidentifies something like pollen or peanuts as a threat, it pumps out IgE, which then binds to mast cells, setting the stage for histamine release. It's essentially an overzealous security detail responding to a guest who didn't bring an invite. 591 (klU/L, ref.interval up to 87)
IgM. 2,44 (g/L, ref. interval 0.4-2.3)
IgG and IgA levels are normal.

These results aren't a direct diagnosis for celiac disease. Instead, they're used to verify how reliable certain screening tests actually are—specifically when measuring IgA and IgG levels. It’s also about ruling out other conditions that might mimic those symptoms, like food allergies.

Specifically, what we’re looking at here is primarily an elevated IgE level. That points toward an allergic tendency, which is something that needs to be factored into the equation. An allergy can certainly run parallel to celiac disease; one doesn't rule out the other.

With celiac disease, you sometimes see low IgM or IgA levels, but that isn't what we're looking at here.

Hey, I'm 17. Went in for blood work over the last couple of days for a routine physical for a job. The day before yesterday was just a standard CBC and urinalysis, then yesterday they did the differential.

CBC RESULTS - only listing things outside the normal range
Leukocyte - 2.97 (ref: 4.4 - 11.6)

DIFFERENTIAL RESULTS - only listing things outside the normal range
Leukocyte - 2.57 (ref: 4.4 - 11.6) - even lower than the day before
Neutrophil granulocytes - 0.73 (ref: 1.49 - 8.00)
Neutrophil granulocytes - 28.4 rel % (ref rel % 34 - 69)
Lymphocyte - 54.5 rel % (ref rel % 19 - 52)
Monocyte - 14.4 rel % (ref rel % 5 - 13)

LIVER RESULTS - only listing things outside the normal range
Aspartate aminotransferase (AST) - 42 U/L (ref: 34 - 69 U/L)

Jacob Scott12 said:LIVER TESTS - I'm only listing what falls outside the normal ranges
Aspartate aminotransferase (AST) - 42 U/L (normal range 34 - 69 U/L)

My bad, I botched the AST numbers. The actual normal range is 11 - 38.

What does a high ferritin level of 690 indicate? This is for a female (78).

Hey there.

Could someone please help me make sense of these results?

Microbiology results following bronchoscopy:

1. Sample microscopic examination: polymorphonuclear: Staphylococcus species (coagulase-negative) 10,000

2. Sample microscopic examination: Acid-fast bacilli NEGATIVE.

3. Sample microscopic examination:Arthrographis sp. ml

Cytology findings:

Lavage: Bronchial epithelial cells.

BAL: Blood, bronchial epithelial cells.

From the blood work:

- (P) PV-INR 0.96 (therapeutic range 2.00-3.50).

Tumor markers:

(S) NSE 15.43 (< 16.30) Note: ECLIA Roche
(S) CYFRA 21-1 3.07 (< 3.30) Note: ECLIA Roche

Thanks so much.

I'm dealing with some issues regarding my weight and metabolism (male, 48 years old, 231 lbs). I managed to drop quite a bit of weight initially, but now, despite staying on a strict deficit, I'm not losing anything—I've just hit a plateau. Because of this, my doctor sent me in for some thyroid testing...

The results are:
Thyroid Test Sample Result Unit Reference Interval
vS Thyroid Stimulating Hormone / TSH (2) 0.725 mIU/L ref. value 0.4 to 4
vS Free Thyroxine / FT4 (2) 13.4 pmol/L ref. value 11.5 to 22.7
Anti-thyroid peroxidase antibodies / Anti TPO (1) 14.2 / kIU/L ref. value vS Thyroglobulin antibodies / Anti Tg (1) 365.6 H kIU/L
So, what does this elevated "Thyroglobulin antibodies / Anti Tg" level actually mean? Is it something I should be worried about? My doctor is telling me everything looks fine, but I'm feeling a bit uncertain.

To looks like the onset of Hashimoto's to me. I could be wrong though... check the thyroid thread.

Hi everyone. I was wondering if I could ask for some help interpreting these lab results. Thanks in advance! 😛
Background: About 4-5 months ago, I started seeing changes in my nails—specifically onycholysis (where all 20 nails begin separating from the nail bed).
According to my rheumatologist, X-rays of my hands didn't show any signs of psoriasis or arthritis. On top of that, all my fungal tests came back negative.
My other blood work, as well as my lung and heart scans, look good.

RF
10 IU/mL
Reference interval < 14

ANA(ENA)IIF
negative
titer
Reference interval < 1:100

HLA-A
3 9
*cdc method - (serological)

HLA-B
35 ND

HLA-C*
04 06
*Method: PCR-SSO/SSP (molecular)

HLA DRB1*
13 -

HLA DQB1*
NT NT

Note: M07

*The condition listed under code (psoriatic arthritis) in the notes is the disease we have been trying to confirm since treatment began.
Does this note mean the disease is confirmed (as a direction), or is it just mentioned because it's what we are currently investigating?
🤔

I understand that typing alone can't confirm a diagnosis—that it really just serves as a test for predisposition toward a certain condition.
Also, I've read in a few studies that HLA-DRB1 is linked to arthritis.

Jacob Scott12 said:Hi. I'm 17. Over the last couple of days, I've been getting blood work done for a routine pre-employment physical. Two days ago, they ran a standard complete blood count and a urinalysis; yesterday was the differential.

Common culprits for results like these include a recent viral infection—or even one you're currently fighting off—along with certain medications. If neither of those applies, you'll need an evaluation and follow-up with a hematologist. Definitely reach out to your primary care physician first.

hollowgardener50 said:What does a high ferritin level of 690 indicate? The patient is a 78-year-old female.

Hello.

These kinds of results can pop up in a wide range of scenarios: inflammation, infections, malignancies, liver or kidney issues, hemochromatosis, or even just excessive alcohol consumption—specifically beer. Obesity and diabetes are also on the list. Given your age, you really need to pay close attention to the possibility of malignant diseases.

Joshua Kim69 said:Please interpret these lab results for me:

Microbiology results following the bronchoscopy:

Microscopic specimen analysis: polymorphonuclear leukocytes Staphylococcus species (coagulase-negative) 10,000

Microscopic examination of the sample: acid-fast bacilli are NEGATIVE.

3. Microscopic sample preparation:Arthrographis sp. ml

Cytology report:

KA L: Bronchial epithelial cells.
KA D: Blood, bronchial epithelial cells.
Bronchial epithelial cell count.

From the blood work results:

- (P) PV-INR 0.96 (therapeutic range 2.00–3.50).

Tumorski notes:

(S) NSE 15.43 (< 16.30) Note: ECLIA Roche
(S) CYFRA 21-1 3.07 (< 3.30) Note: ECLIA Roche

Much appreciated.

Essentially, the cytology came back clear—no malignant cells were detected, and tumor markers are sitting right at the upper limit of the normal range. However, even with no signs of malignancy here, this doesn't completely rule out lung cancer. Regarding the microbiology, tests for mycobacteria (including the agent responsible for tuberculosis) were negative. They did pick up coagulase-negative staphylococcus, which is typically just a contaminant rather than an actual pathogen, along with a single fungus/mold. Molds like that are frequently isolated from the respiratory tract, skin, or nails; they’re generally considered contaminants and rarely cause issues unless there are visible changes in the nails where it originated. As for the PV levels, everything looks normal for someone not currently on anticoagulant therapy.

silverfalcon412 said:Hi there. I’d appreciate some help interpreting these results. Thanks in advance. 😛
(...)
Also, I read that some studies link HLA-DRB1 to arthritis.

Check those results again—specifically the "HLA-DRB1*" section. Is there any number listed other than 13?

Otherwise, you misread the literature. It isn't HLA-DRB1 that links to rheumatoid arthritis, it's HLA-DRB1*04. That's a significant distinction.

Until you verify that finding, go back and re-read what I wrote earlier regarding this topic:

Maria Fisher46 said:The core logic of this testing is based on the fact that certain HLA antigens show up more frequently in people with specific diseases than in healthy populations.

Essentially, having certain antigens is tied to a slightly higher risk of developing a particular condition. This doesn't mean anyone carrying that antigen is destined to get sick. Likewise, someone can fall ill without having the antigen at all.

Regarding your specific lab work, I see you have HLA-DRB1*04, which can be associated with rheumatoid arthritis.

However, it's far from being as straightforward as it looks. Within the HLA-DR4 category, there are over 30 subtypes (labeled HLA-DRB1*0401 through *0433). Only a few of these are actually linked to rheumatoid arthritis—most notably DRB1*0401 and DRB1*0404.

Your current report won't show those granular details because the typing wasn't performed at that level of depth.

For more on the connection between HLA and various diseases, take a look here: http://www.ncbi.nlm.nih.gov/pmc/arti...7156/table/T1/

Maria Fisher46 said:One more thing—double-check those lab results, specifically the "HLA-DRB1*" section. Is there any number listed besides 13?

Otherwise, there might be a bit of a misunderstanding here. It isn't actually HLA-DRB1 that's linked to rheumatoid arthritis—it's HLA-DRB1*04—and that is a massive distinction to make.

Until you can verify that specific finding, I'd highly recommend revisiting what I mentioned earlier regarding this topic:

Thank you for getting back to me 🙏
I just checked, and there isn't another number; the first box shows 13, while the second one just has a dash (-). What does that dash signify?
Based on everything we've discussed, would it be fair to say that I'm at a higher risk of developing arthritis?

silverfalcon412 said:Thank you for your response. 🙏
I checked, and there isn't a second number. The first box shows 13, while the second one just has a dash (-). What’s that dash supposed to mean?
Based on everything we've discussed, can it be said that my risk of developing arthritis is higher?

So, you're only carrying HLA-DR13.

Based on your HLA typing results, you have a genetic predisposition for psoriasis (HLA-C*06) and hemochromatosis (HLA-A3). Both conditions can manifest through changes in the skin and joints. You don't show a predisposition for rheumatoid arthritis.

Given the nail changes combined with these HLA typing results, it looks like things might be heading toward psoriasis. This will likely serve as the roadmap for how we handle everything moving forward.

Maria Fisher46 said:Common reasons for results like this include having gone through a viral infection (or being in that "recovering" phase) or taking certain medications. If neither of those fits, you'll need an evaluation and further follow-up with a hematologist. Definitely check in with your primary care physician first!

Thanks for the reply. Heading to the hematologist tomorrow, so we'll see what's actually going on...

Hi there. I was hoping to get some insight regarding my mother's recent blood work. She’s 73 and living with Parkinson's disease, which has left her partially immobile. Over the last couple of months, we’ve noticed a pretty steady decline in her erythrocyte, hemoglobin, and hematocrit levels.

Here is what her labs looked like back in May:
Erythrocyte 3.84 (3.86-5.08)
Hemoglobin 110 (119-157)
Hematocrit 0.342 (0.356-0.470)
The next set of results from July 12th showed a really sharp drop in those numbers:
Erythrocyte 2.83
Hemoglobin 83
Hematocrit 0.251

On top of that, a few other things were outside the normal range, so I was wondering if someone could help explain those too. For instance,

Eosinophil 9.75 (0-7)
Basophil is within normal limits 0.80 (0-1)
Lymphocyte 19.70 (20-46)

Because of these readings, her primary care doctor sent her to the ER for an urgent evaluation, where they drew more blood on July 14th:

Erythrocyte 2.96
Hemoglobin 89
Lymphocyte 12.3
Eosinophil 2.4
Basophil 0.9

Aside from that, a quick check of the lower GI tract ruled out any acute bleeding. They mentioned that a transfusion wasn't necessary at that time.

Then, the very next day, July 15th, she had blood drawn again. They also ran some tumor markers; the report shows ferritin at 78.25 (reference range 4.63-204.00), but I'm a bit confused about which specific types of cancer these tests are meant to rule in or out.

Erythrocyte 2.81
Hemoglobin 83
Hematocrit 0.246
Eosinophil 10.60 (0-7)
Basophil 1.27 (0-1)
Lymphocyte 25.30 (20-46)
Iron 6.9 (8.0-30.0)
TIBC 41.1 (49.0-75.0)

I guess I'm wondering why the lymphocyte counts seem to be fluctuating so wildly? Also, does anyone know what TIBC actually stands for?

I suppose I'm also looking for advice on how to handle these low erythrocyte, hemoglobin, and hematocrit levels, and maybe what might be causing this. I'm honestly feeling quite panicked and worried, especially since these changes aren't just minor—they seem to be happening almost daily.

Hi everyone, I just got some results back for my thyroid and certain sex hormones (I’ll probably need to run more tests soon too...)

I'm female, and my androstenedione came back at 13.8 (using the CLIA method; the reference interval is 0.7-12.9)

Note and comment: D5

Could someone help me make sense of this before my doctor's appointment? These were just part of my annual checkup... what could this mean?

I also had LH, FSH, PRL, and a full thyroid panel done. If it helps, I can post all my other values too. Also, my T/P ratio is right at the lower limit at 23, and the T/P ratio is also at the bottom at 0.9, while my fibrinogen is at the high end at 3.4. I'm not on any birth control. I've been having pretty heavy periods lately...
If you think I should provide any more info, please let me know.

Hi,
My wife had some blood drawn via finger prick at a private doctor's office, and these were the results:
Biochemical analysis:

P-AMYL= 14.0
HG= 6.75

I assume the first one refers to amylase, but I have no clue what HG stands for. Anyway, the doctor told her her immune system seemed weak and gave her a Vitamin B injection.
Personally, I don't see how those two things are connected. I'd appreciate any thoughts you all might have!

Hey everyone, just got my tissue typing results back and would love some input🙂
HLA-A 0203
HLA-B 08ND
HLA-DRB1* 0311

For about a year now, I've been dealing with joint pain—mostly hitting my hands the hardest. Over the last two months, one of my fingers has been swelling up pretty badly. On top of that, I've had some seriously intense pain in my shoulder and hip lately. My Rheumatoid Factor came in high at 53, and Anti-CCP is sitting at 721.
No official diagnosis yet, but there's a strong suspicion that rheumatoid arthritis might be starting.
I'm 28.

Thanks in advance!

At the Breyer Clinic, they ran a Troponin I test where the reference range is listed as div>