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Lab results - looking for opinions [PLEASE READ 1ST POST]

Started by Sam Hall15 · · 👁 27 views · 1.8K replies

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Participants Sam Hall15Laura Lopez29Alexander Hughes2Ashley RamirezSandra Reyes7George Clark19Harold Ramirez49Gerald Lewis36Hannah Phillips50John Parker6darkmakerwearysailor3Kimberly Hughes23Walter Myers4coastaljackal8Elizabeth Ross48Susan Ruiz76darkraven10Frank Wright7Chloe Lee72Morgan Miller7Justin Parker4hiddensurfer17feralfox12 …
Kimberly Edwards2 Kimberly Edwards2 Newcomer
3 messages
joined Nov 2008
#1681 ·
I’m definitely going to seek out a second opinion. Even though I’ve already seen a specialist internist—and from what I hear, they're top-tier—there's always that nagging possibility of a mistake or a missed conclusion. So, why wouldn't I ask someone else?
vividsailor7 vividsailor7 Active Member
217 messages
joined Sep 2011
#1682 ·
Kimberly Edwards2 said:I’m definitely going to seek out another opinion. Even though I saw a specialist internist—and they say he’s top-tier—there’s always that nagging possibility of a mistake or a missed conclusion. Why wouldn't I ask someone else?

Look, you're absolutely right. You have every right to get a second opinion.
Alex Price51 Alex Price51 Newcomer
2 messages
joined Oct 2011
#1683 ·
Does anyone happen to know what this means:

Erythrocyte sedimentation rate - 1h value 31 Ref interval 4-24

Generally, my blood work looks great; everything is within the normal range except

Cholesterol 5.4 Ref value 0-5
LDL cholesterol 3.4 Ref value up to 3

So, it’s probably not too bad.

Urinalysis

Leukocyte high ref interval 0-2
Squamous epithelial cells A little
Bacteria A little

This is for a 36-year-old woman!

I’ve never had an elevated erythrocyte sedimentation rate before, so I’m getting a little anxious because the internet says all sorts of things about different diseases.

Maybe someone else has had something similar??🤷
vividsailor7 vividsailor7 Active Member
217 messages
joined Sep 2011
#1684 ·
Alex Price51 said:Maybe someone knows what these results mean:

Erythrocyte sedimentation rate - 1h value 31 Ref interval 4-24

Otherwise, the blood work is great; everything is within normal limits except

Cholesterol 5.4 Ref value 0-5
LDL cholesterol 3.4 Ref value up to 3

so it's not that bad.

Urinalysis

leukocyte high ref interval 0-2
Squamous epithelial cells Some
Bacteria Some

This is for a 36-year-old woman!

I've never had an elevated erythrocyte sedimentation rate before, so I'm getting a little anxious because the internet says just about anything regarding various diseases!?

Has anyone dealt with something similar??🤷

Did you people even read the first post? I have no idea why.
No, just slightly elevated cholesterol. Everything else looks fine—assuming you actually bothered to read the first post.
Alex Price51 Alex Price51 Newcomer
2 messages
joined Oct 2011
#1685 ·
vividsailor7 said:I guess you guys didn't read the first post. I don't know why.
No, cholesterol is slightly elevated. Everything else looks normal, I guess, if you haven't read my first post yet.

The other values on the blood count look fine, so I guess everything else is within the normal range.

The reason I had my blood work done was because I've been feeling nauseous and just generally unwell for quite some time now. This nausea seems to last all day long.

I had a bladder infection caused by E. coli, but I don't have any issues with that right now. When I had the bladder infection, my erythrocyte sedimentation rate wasn't elevated.
vividsailor7 vividsailor7 Active Member
217 messages
joined Sep 2011
#1686 ·
Alex Price51 said:Everything else on the blood work looks fine; basically, everything is within the normal range.

The whole reason I went in for blood work was because I’ve been feeling nauseous and just generally miserable for quite some time now. This nausea? It lasts all damn day!

I dealt with a bladder infection caused by E. coli recently, but I don't have any issues with that right now. Back when I actually had the bladder and vaginal inflammation, my erythrocyte sedimentation rate wasn't even elevated.

Conclusion: perfectly clean results.
melloworca6 melloworca6 Regular
551 messages
joined May 2010
#1687 ·
I have a question for all the doctors on here, but please don't kill me for not typing out my whole report—it’s massive because I just had a full immunological workup done.

I found my latest immunology results and noticed there’s a note and a "DZ 97" comment, whereas my other similar reports don't show anything. What does DZ 97 mean? I know it’s a code, but what for?

For context, I have hypothyroidism, Raynald, and an undefined collagen disease that they suspect might be Sjogren.

edit: fine, I’ll type it out since it’s right in front of me. Reference values are in parentheses.

Immunoglobulin G - 25.40 (7.0-16.0)
Immunoglobulin A - 5.71 (0.7-4.0)
Immunoglobulin M - 2.56 (0.4-2.3)
C3 - 0.98 (0.9-1.8)
C4 - 0.06 (0.1-0.4)
Circulating immune complexes - 76 (<50)
Serum protein immunofixation electrophoresis - no monoclonal proteins present
Cryoglobulins - none present

Autoimmune disease serology:

Anti-dsDNA - 23 (negative below 100)
ENA screen - POSITIVE
Anti-SS-A/Ro - 859 (positive above 120)
Anti-SS-B/La - 314 (positive above 120)
Anti-Sm - 156 (positive above 120)
Anti-Sm/RNP - 407 (positive above 120)
Anti-Jo-1 - 33 (negative below 100)
Anti-Scl-70 - 118 (borderline from 100 to 120)
Anti-histone - 129 (positive above 120)
Anticentromere antibodies - 93 (negative below 100)
Cardiolipin antibody screen - NEGATIVE
MPO antibodies (pANCA) - 81 (negative below 100)
PR-3 antibodies - 12 (negative below 100)
ANF - POSITIVE
ANF titer - 1:10000 (highly positive titer above 1:3200)
ANF fluorescence pattern: CYTOPLASMIC AND PUNCTATE

Notes and comments - DZ 97
vividsailor7 vividsailor7 Active Member
217 messages
joined Sep 2011
#1688 ·
melloworca6 said:I have a question for all the doctors on here, but please don't kill me for not typing out my entire lab report—it’s just way too long since I had a full immunological workup done.

I just dug through my latest immunology results and noticed there’s a specific note and a "DZ 97" comment on this one, even though none of my previous lab reports ever had anything like that. I know it's some kind of internal code, but does anyone actually know what DZ 97 stands for? What is it referring to?

So, just to give you some context on my situation: I’m dealing with hypothyroidism, Raynald syndrome, and an undefined collagen disease that they suspect might actually be Sjogren.

Edit: Actually, I’ll just go ahead and transcribe the results since I have them right here in front of me. The reference ranges are in parentheses.

Immunoglobulin G - 25.40 (7.0-16.0)
Immunoglobulin A is sitting at 5.71 (normal range is 0.7 - 4.0).
Immunoglobulin M - 2.56 (0.4-2.3)
C3 - 0.98 (0.9-1.8)
C4 - 0.06 (0.1-0.4)
Circulating immune complexes - 76 ( Serum protein immunofixation electrophoresis results: No monoclonal proteins detected.
Cryoglobulins—not present.

Autoimmune disease serology:

Anti-dsDNA - 23 (negative if under 100)
ENA screen - POSITIVE
Anti-SS-A/Ro testing came back at 859—which is obviously positive since anything over 120 is considered a hit.
Anti-SS-B/La - 314 (positive, anything over 120 is a hit)
Anti-Sm - 156 (positive, anything over 120 is considered high)
Anti-Sm/RNP - 407 (positive, anything above 120 is considered positive)
Anti-Jo-1 - 33 (negative, anything under 100 is negative)
Anti-Scl-70 is sitting at 118—right on the edge of that 100 to 120 threshold. Just hovering there.
Anti-histone antibodies—129 (positive, anything over 120 counts).
Centromere antibodies - 93 (negative if below 100).
Cardiolipin antibody screen - NEGATIVE
Anti-MPO antibodies (pANCA) came back at 81—which is technically negative since anything under 100 is considered normal.
Antibodies for PR-3 - 12 (negative, anything under 100 is fine)
ANF - POSITIVE
ANF titer - 1:10,000 (that is a massively positive titer, anything over 1:3,200 is huge).
ANF fluorescence tip: CYTOPLASMIC AND PUNCTATE

Notes and comments - DZ 97

Oops, just the leftovers from yesterday.
Tested positive for autoimmune diseases. Also positive for Sy, Sjogren, and SLE.
And there's one more thing that seems fishy to me, but I'll hold off on saying that until you guys give me a quick rundown of your own symptoms.
So, let me give you the rundown on what I've been dealing with. To put it simply: here's everything that's going wrong.
melloworca6 melloworca6 Regular
551 messages
joined May 2010
#1689 ·
So, could it actually be lupus?

Regarding those symptoms tied to my undefined connective tissue disorder, I’ve got swelling in my joints (especially the small ones in my fingers), dry eyes—basically no tears at all (I was diagnosed with keratoconjunctivitis sicca)—and dry mouth from a lack of saliva...

Honestly, I don't even think Sjogren is on the table for me. What's bothering me is whether it could be lupus, because Sjogren, Raynald, and thyroid issues (they haven't confirmed Hashimoto yet, but there's suspicion since my anti-Tg is borderline) can all be linked back to lupus.
frozenhawk0 frozenhawk0 Newcomer
3 messages
joined Feb 2010
#1690 ·
If anyone has the patience and wants to take a look at my labs and try to make sense of them, I’d be super grateful!

I got bloodwork done because I lost about 50% of my hair in just one month (diffuse thinning, mostly when washing or in clumps), and I'm getting these rashes/lesions popping up on my body—mostly my chest and arms. I saw a dermatologist who sent me for blood tests to check my thyroid and for H. pylori.
I have PCOS and have been on Diane for three years. Before I started those, I had my thyroid checked and my TSH was 7. No one really reacted to it back then; my endocrinologist just had me retest two months later when the TSH dropped to 2.5. I've never taken anything for my thyroid.
Not sure if this matters, but I lost 15 lbs three months ago.

As for the standard CBC stuff, everything looks okay except my erythrocyte count is 3.73 (ref 3.86-5.08).
Here’s the full biochemistry breakdown:

Glucose 5.4 (4.4-6.4)
Bilirubin-total 6 (3-20)
Urea 3.2 (2.8-8.3)
Creatinine 73 (63-107)
Urate 189 (134-337)
Alkaline phosphatase 49 Aspartate aminotransferase 16 (8-30)
Alanine aminotransferase 9 (10-36)[\B]
GGT 9 (9-35)
Creatine kinase 36 (0-153)
Lactate dehydrogenase 117 Alpha amylase 87 (23-91)
Cholesterol 6.7 Triglycerides 1.52 HDL 1.94 >1.2
LDL 4.10 Potassium 4.7 (3.9-5.1)
Sodium 136 (137-146)
Total calcium 2.42 (2.14-2.53)
Chloride 104 (97-108)
Iron 9 (8-30)
UIBC 72 (26-59)
TIBC 81 (48-79)
Protein 69 (66-81)
Ferritin 5.87 (15-150)

They also ran some markers:
CA 125 33.27 CA 15-3 12.22
Thyroid results:
FT4 12.9 (10-25)
FT3 4.6 (3.6-7.8)
TSH 1.39 (0.4-4.2)
hTgAb 40 TPO-Ab 225 b>

Helicobacter pylori (ELISA)
IgG negative
IgA borderline (they didn't give numbers, just wrote that... and they didn't test for IgM)
melloworca6 melloworca6 Regular
551 messages
joined May 2010
#1691 ·
frozenhawk0 says:
Thyroid labs:
FT4 12.9 (10-25)
FT3 4.6 (3.6-7.8)
TSH 1.39 (0.4-4.2)
hTgAt 40 TPO-At 225 b>



Here’s my take on this.

Your thyroid hormones (ft3, ft4, tsh) look fine, but your thyroid antibodies (anti TPO) are elevated. High antibodies usually point toward an autoimmune thyroid condition—like Hashimoto's causing hypothyroidism or Graves' causing hyperthyroidism. In your case, it looks like it's still in the early stages since your hormone levels are still within the normal range.

That hair loss could definitely be linked to it. A lot of people start feeling the symptoms of thyroid issues long before the actual lab work shows anything out of the ordinary.
vividsailor7 vividsailor7 Active Member
217 messages
joined Sep 2011
#1692 ·
frozenhawk0 says:
I would be so incredibly grateful if someone could please find the patience and willingness to look over my lab results and help me make sense of them!

I had blood work done because I lost about 50% of my hair in just one month (it’s falling out everywhere—diffuse thinning, during washing, and in clumps), and I’m also breaking out in these rash-like spots all over my body (on my chest and arms). I saw a dermatologist who sent me for blood work and told me to get screened for thyroid issues and H. pylori.
By the way, I have PCOS and have been on Diane for three years. Before I started taking those, I had my thyroid checked and my TSH was 7. Nobody really reacted to it at the time; my endocrinologist just sent me back to retest two months later when the TSH had dropped to 2.5—I've never taken anything for my thyroid.
I don't know if this matters, but I lost 15 lbs about three months ago.

As for the "standard" hematology stuff, everything looks fine except for my erythrocytes, which are 3.73 (ref range 3.86-5.08).
I'll type out the full biochemistry panel here:

Glucose 5.4 (4.4-6.4)
Bilirubin-total 6 (3-20)
Urea 3.2 (2.8-8.3)
Creatinine 73 (63-107)
Urate 189 (134-337)
Alkaline phosphatase 49 Aspartate aminotransferase 16 (8-30)
Alanine aminotransferase 9 (10-36)[\B]
Gamma-glutamyl transferase 9 (9-35)
Creatine kinase 36 (0-153)
Lactate dehydrogenase 117 Alpha amylase 87 (23-91)
Cholesterol 6.7 Triglycerides 1.52 HDL 1.94 >1.2
LDL 4.10 Potassium 4.7 (3.9-5.1)
Sodium 136 (137-146)
Total calcium 2.42 (2.14-2.53)
Chloride 104 (97-108)
Iron 9 (8-30)
UIBC 72 (26-59)
TIBC 81 (48-79)
Proteins 69 (66-81)
Ferritin 5.87 (15-150)

They also ran some markers:
CA 125 33.27 CA 15-3 12.22
Thyroid results:
FT4 12.9 (10-25)
FT3 4.6 (3.6-7.8)
TSH 1.39 (0.4-4.2)
hTgAb 40 TPO-Ab 225 b>

Helicobacter pylori (ELISA)
IgG negative
IgA borderline (they didn't give numbers, it just says that... and they didn't test for IgM)



Iron deficiency anemia.
Elevated total cholesterol and poor lipid profile.
Elevated thyroid antibodies, though hormone levels are currently normal.
Conclusion: You should probably take an iron supplement. Diet definitely needs adjusting (due to the anemia and high lipids). Get a thyroid ultrasound done.
This is an example of how a well-structured inquiry should look.
frozenhawk0 frozenhawk0 Newcomer
3 messages
joined Feb 2010
#1693 ·
melloworca6 said:I can weigh in on this.

Your thyroid hormones look fine (ft3, ft4, tsh), but those anti-TPO antibodies are elevated. Usually, that points to an autoimmune issue like Hashimoto's causing hypothyroidism or Graves' causing hyperthyroidism. Since your hormone levels are still normal, it's probably just the early stages.

The hair loss could definitely be from that. A lot of people start feeling symptoms before the lab work actually shows anything's wrong.

vividsailor7 said:Iron deficiency anemia.
High UK and bad cholesterol.
Elevated thyroid antibodies, though hormones are steady for now.
Bottom line: You should probably take an iron supplement. Definitely fix up the diet (for the anemia and the lipids). Get a thyroid ultrasound.
This is how you write a decent, well-structured inquiry.

Thanks for the quick replies. 🙂
Like I mentioned—I dropped 15kg and I'm trying to eat as clean as possible. Regarding the iron, I don't think it's a diet thing. I've had blood work done over the last few years back home and my iron has never been even close to low. I last had labs done after dieting two months ago and it was fine too... so that's what's confusing me.

Oh, you guys mentioned—could this be why my hair is falling out?
Not to exaggerate, but I feel like I've lost at least 50% of my hair.🙂
melloworca6 melloworca6 Regular
551 messages
joined May 2010
#1694 ·
frozenhawk0 said:Thanks for the quick replies. 🙂
Like I mentioned—I’ve dropped 15kg and I’m eating as clean as possible. As far as iron goes, I don't think it's a diet issue. I've had blood work done over the last few years back home and my iron levels have never been anywhere near low. I actually just had blood drawn after my diet two months ago and everything looked fine. That's why I'm confused..

Oh, and you guys mentioned—can this cause hair loss?
Not to exaggerate, but I feel like I've lost at least 50% of my hair. 🙂

I'm missing half my hair, half my eyebrows, and two-thirds of my eyelashes too. 🙂 It's probably the thyroid.
vividsailor7 vividsailor7 Active Member
217 messages
joined Sep 2011
#1695 ·
frozenhawk0 said:Thanks for the quick replies, everyone! 🙂
Like I mentioned earlier—I’ve dropped 15kg and I'm doing my absolute best to eat right. As far as iron goes, I really don't think it's a diet issue. I've had blood work done over the last few years here at home, and my iron levels have never been anywhere near low. I even had my blood drawn after the diet two months ago, and everything looked fine... so that's what's throwing me off.

Oh, and you guys asked—can this cause hair loss?
Without being dramatic, I feel like I've lost at least 50% of my hair.🙂

It could be from the anemia or the thyroid issues.
melloworca6 melloworca6 Regular
551 messages
joined May 2010
#1696 ·
melloworca6 said:So, could it actually be lupus?

Regarding those symptoms from my undefined collagen disease, I’ve got swollen joints (especially the small ones in my fingers), dry eyes—basically zero tears, which led to a diagnosis of keratoconjunctivitis sicca—and a dry mouth, meaning no saliva...

Honestly, I don't think Sjogren is even on the table for me right now. My main concern is whether it could be lupus, because both Sjogren and Raynald, along with thyroid issues (they haven't confirmed Hashimoto yet, but there's suspicion since my anti-Tg is borderline), can all be linked back to lupus.

Anyway, let me repeat my post to Hrvoje. 😁
vividsailor7 vividsailor7 Active Member
217 messages
joined Sep 2011
#1697 ·
melloworca6 said:So, you think it could actually be Lupus?

Regarding those symptoms from my undefined collagen disorder—I've got swelling in my joints (especially the small ones in my fingers), dry eyes, or rather a total lack of tears (I actually got diagnosed with keratoconjunctivitis sicca), and dry mouth due to a lack of saliva...

Honestly, I don't even think Sjogren is the main issue here. What's eating at me is whether this could actually be Lupus. Both Sjogren and Raynald, along with my thyroid issues (Hashimoto isn't confirmed yet, but there's suspicion because my anti-Tg is right on the borderline), can all be side effects of Lupus.

For Lupus, you look at markers like Anti-Sm, Anti-Sm/RNP, and Anti-histone. It’s the same deal for Sy. For Sjogren, you check Anti-SS-A/Ro and Anti-SS-B/La.
So, we're looking at either Sy.Sjogren or SLE.
Some of the results are just barely elevated.
The immunologist will have the final word.
If anything else is unclear, just ask.
melloworca6 melloworca6 Regular
551 messages
joined May 2010
#1698 ·
vividsailor7 said:For Lupus, you look at these markers: Anti-Sm, Anti-Sm/RNP, and Anti-histone. Those are also used for Sy. For Sjogren: Anti-SS-A/Ro and Anti-SS-B/La.
So, it could be Sy.Sjogren or SLE.
Some of the results are borderline high.
The immunologist gets the final say.
If anything else isn't clear, just ask.

I don't know why, but I've realized that histones are specific to Sjogren.

As for a Lupus diagnosis, I don't have one yet because my anti-dsDNA is normal, my LE cells are negative, and my lupus anticoagulant is normal. The only thing is I haven't had ANA antibodies checked yet, and those are usually elevated in most people with Lupus.

I forgot to mention that my CBC, ESR, CRP, and urine tests have always been fine so far (actually, my sedimentation was up by 20 units just last time, but that was right when my left elbow was super swollen, so I figure that was the reason).

Oh, and I also had a serum protein electrophoresis done recently, here are those results:

Total protein 94.9 g/l
A/G: 1.33

Albumin - 57.0% (58-70) 54.1 g/l (42-50)
Alpha 1 - 1.8% (1-2.8) 1.7 g/l (0.7-2)
Alpha 2 - 7.1% (7-12) 6.7 g/l (5-9)
Beta - 7.8% (9-14) 7.4 g/l (6-10)
Gamma - 26.3% (8-17) 25.0 g/l (6-12)

Comment: hypergammaglobulinemia

So, if you can explain what this means—this is basically the only part of the results I don't understand or know why they even ran it.
Nicholas Myers Nicholas Myers Active Member
163 messages
joined Jan 2012
#1699 ·
melloworca6 said:Comment: hypergammaglobulinemia

So, could you explain what this actually means? It’s really the only thing in my results that I don't understand or why they even tested for it.

Ma'am,

If you'll allow me, I'd like to weigh in on this discussion as well.

The ANA/ANF test—that's what you've already covered here.

As for the hypergammaglobulinemia, it points toward a Sjogren diagnosis, given that the disease involves B-lymphocyte activation, which produces gamma globulins.

The critical factor is that there is no monoclonal protein in the electrophoresis results; that's important because its presence would raise suspicions of malignant changes (Non-Hodgkin lymphoma is more common in Sjogren patients than in the general population).

Regarding an SLE diagnosis, beyond just the serology, a thorough evaluation of various organ systems and careful attention to all symptoms is vital. Personally, I would lean toward following your immunologist's assessment rather than rushing to an SLE diagnosis.

That’s all from me for now. I'll let vividsailor7 add anything else he deems necessary.

Best regards. 🙂
melloworca6 melloworca6 Regular
551 messages
joined May 2010
#1700 ·
Thanks everyone for all the responses.🙂

Basically, I already had a pretty good idea about most of this because I’ve spent quite a bit of time digging through books and searching online. I know my doctors are essentially trying to figure out if this is just Sjogren's or if it's actually tied up with SLE (honestly, I'm praying it's just Sjogren's).

The only thing that really threw me off was the whole serum protein electrophoresis thing. I stumbled upon some stuff online mentioning non-Hodgkin lymphoma, and seeing that in relation to my results actually spooked me a little.

edit: one more quick question—what exactly constitutes a monoclonal protein? If that comes back positive, what would my results look like (I mean, besides gamma globulins, what else would be elevated)?

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