Lab results - looking for opinions [PLEASE READ 1ST POST]

Jose Doyle89 said:Calcium really should be above 3 or so before we start worrying about anything else. Plus, there need to be other symptoms present for this to actually point toward something specific. How old are you? Has a doctor looked over these results yet? If you have kidney issues, maybe focus on that first. Honestly, the lab work looks fine on its own, but without an actual physical exam and seeing your previous medical history, there isn't much else to say.

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Just waiting on the doctor's take. So far, I've only received the lab report.

So, we’re back for our regular check-up—it’s an eight-year-old with lymphadenopathy. I’m looking at this slight shift in the erythropoiesis levels and wondering, is this actually something to worry about, or just normal fluctuation? We’ve got more testing scheduled in a few months regardless, but still.
On top of that, looking at the same sample, the lymphocyte count on the cytological smear came back at 55%, which is a pretty significant jump from before and sits just a bit above the upper limit of the normal range.
The ultrasound results haven't changed; there are still plenty of enlarged nodes, but they all look like they're just reactive in nature.
Other than that, nothing else seems to be bothering them.

Emily Ortiz27 said:Our routine checkup—an eight-year-old with lymphadenopathy. I’m looking at this change in erythrocytes; is it alright? We have new tests scheduled in a few months regardless.
Also, from that same sample, the lymphocyte count on the cytological smear is 55%, which deviates significantly from previous results and sits just above the upper limit of normal.
Ultrasounds show no changes; numerous enlarged nodes present, though they look reactive in nature.
No other symptoms reported.

Ma'am,

If I recall correctly, there was no anemia in the previous labs? Current results show normocytic anemia—borderline, certainly, but still a shift compared to historical data. I'm not sure how frequently you run blood counts, but I would repeat this in about four weeks to see the trajectory. If we observe a downward trend, we should then determine the reticulocyte count.

I just got my blood typing results back today. There's a note at the bottom of the report:
No anti-erythrocyte antibodies were found in the plasma.
Can someone explain what this actually means in plain English?

northerncobra33 said:I received my blood typing results today. There's a note at the bottom:
No anti-erythrocyte antibodies were detected in the plasma.
Can someone explain what this actually means?

Hello,

That’s a good result. If anti-erythrocyte antibodies were present, there would be a risk during a transfusion—essentially, the recipient's immune system attacking the donor's red blood cells once they enter the bloodstream, leading to hemolysis and other complications. Since none were found, you're in the clear.

Hello,
I wanted to ask if it’s actually dangerous when someone has a platelet count of 141, given that the reference range is 158-424. All the other parameters look fine—both the hematology and biochemistry tests came back normal.

hollowviper said:Hello,
I wanted to ask if it's dangerous when someone has a platelet count of 141, given the reference range is 158-424. All other parameters—both hematology and biochemistry—are normal.

Ma'am,

That number alone isn't an immediate danger. The real question is finding out why it happened in the first place.

Maria Fisher46 said:Hi there,

As far as I can recall, wasn't anemia absent in your previous labs? Now we're seeing normocytic anemia—it's borderline, sure, but it's still a shift compared to what you had before. I'm not sure how often you're getting blood work done, but if I were you, I'd run the CBC again in about four weeks just to see which way the wind is blowing. If it looks like things are trending downward, then we'd probably want to check those reticulocyte counts next.

Thanks.
We basically monitor everything every 2-3 months, though my hematologist actually mentioned we could even wait longer between checks now.

I haven't dealt with anemia until now, but looking back at my smears, there’s almost always a note about hypochromia.

Greetings,
I require a review of these lab results.
I gave birth ten months ago. There was significant postpartum bleeding, and I had blood work done shortly after delivery which showed low iron levels. I was prescribed Iron, but I took it for only a few days before experiencing constipation.
I had more blood work performed a few days ago; the results are attached. My doctor called me to state she will not prescribe anything else for the iron deficiency. She advised me to purchase an over-the-counter syrup at the pharmacy (Floradix) instead and to repeat the blood tests in six weeks.
I am 27 years old. I have had two births within a two-year span (consecutive pregnancies). My weight is 60 kg and my height is 176 cm.
I would characterize my menstrual cycles as moderate to heavy.

Maria Fisher46 said:Ma'am,

What you've listed doesn't inherently pose any danger by itself. The real issue, though, remains figuring out what's actually causing this to happen.

And which tests would you suggest? I mean, is it even possible for someone to be losing blood somewhere with platelet counts at that level? Like, maybe some kind of internal bleeding in the stomach.
Thanks

Has anyone else here dealt with yellowing under their eyes during early pregnancy? Of course, the alarm bells immediately start ringing about potential bladder or kidney infections, but then you get a full blood panel back and it shows absolutely nothing.

Emily Ortiz27 said:Thanks.
We usually check in every 2 or 3 months; lately, the hematologist even suggested we could wait longer between appointments.

No anemia so far, though the blood smear almost always shows some hypochromia.

Since there hasn't been any actual anemia yet, I’d suggest repeating the tests in 1 to 2 months. I wouldn't wait any longer than that.

Sarah Anderson35 said:Hi there,
https://i.postimg.cc/DfMyQSpV/389323...7411104-AA.png
I need someone to look over these results.
I gave birth 10 months ago. There was significant bleeding, and I had blood work done postpartum showing low iron. I started taking Iron, used it for a few days, then stopped (constipation issues).
Had blood work done a couple of days ago; here are the results. My doctor called and said she won't prescribe anything else for the iron—just suggested I pick up some syrup at the pharmacy (Floradix) and retest in about six weeks.
I'm 27, had two births in two years (back-to-back), 60 kg / 176 cm.
Periods are generally moderate to heavy.

To whom it may concern,

Since the ferritin concentration is below 30 ug/L, this is moderately classified as iron deficiency without anemia. It is recommended to implement dietary changes—specifically including meat, poultry, and fish at least five days a week, alongside legumes and leafy greens—while using iron supplements and undergoing periodic monitoring of hemoglobin and ferritin levels.

In consultation with a primary care physician, one should investigate the underlying causes and take appropriate measures.

hollowviper said:What tests would you recommend? Is it possible for someone to be losing blood somewhere with platelet counts like this? For instance, internal bleeding in the stomach.
Thanks

Given those platelet levels, there isn't a strict indication for more intensive workup just yet, so I’d suggest simply monitoring the count for now. While low platelets can lead to spontaneous bleeding, what you're describing doesn't typically correlate with a lower platelet count.

Douglas Parker3 said:Has anyone else dealt with yellowing under the eyes during early pregnancy? Naturally, the alarm bells start ringing regarding potential bladder or kidney infections, yet a standard complete blood count shows absolutely nothing.

Ma'am,

A standard blood count isn't going to flag a bladder infection, nor will it measure kidney function.

Maria Fisher46 said:Dear Sir,

Based on what I am seeing, you are experiencing lymphopenia, which requires further investigation.

The primary question is, what does your blood work typically look like? (I assume you have had blood counts performed at various times throughout your life.) In other words, is this deviation in your leukocyte count a new finding since January 2022, or do you have records indicating that your leukocytes have always sat at the lower end of the normal range? Have you been ill within the last 6 months? Is it possible you dealt with an infection, a fever, or generally felt unwell during that period? Have you undergone any medical examinations relatively recently? Do you engage in high-risk sexual activity? Are you currently taking any medications? Do you consume alcohol? What is your body weight, and has it changed over the past 6 months? Have you experienced any severe infections in the past? Any fevers, night sweats, rashes, or skin changes?

My blood work from June and July remains unchanged, with a continuing decline in both leukocytes and lymphocytes.
Additional tests including HIV, Hib, minerals, folic acid, EF serum protein, and B12 all came back normal.
I am currently waiting on results for tests already performed: a bone marrow biopsy and analysis, immunophenotyping of the bone marrow, FISH, and a karyotype. They told me at the Mayo Clinic that I would be waiting about 2 months.

I am not sure what to expect.

Thank you.

Carl Thompson26 said:My blood work from June and July hasn't budged—white blood cell and lymphocyte counts remain low.
Ran additional tests for HIV, Hib, minerals, folic acid, EF serum protein, and B12. Everything came back normal.
Currently waiting on results from a bone marrow biopsy and analysis, including immunophenotyping, FISH, and a karyotype. They told me at the Mayo Clinic it could take about two months.

I'm not sure what to expect.

Thanks

Hello,

It’s now time to rule out any malignant causes for this specific constellation of findings you're seeing. Let's hope the results don't lean in that direction. Not all results take two months to process. Cytology results are usually ready very quickly, and immunophenotyping typically follows shortly after. While FISH and karyotyping take a bit longer, you might want to check in regarding the cytology (usually just a day or two after the biopsy) and the immunophenotyping (roughly within a week; though things might be moving slower lately due to summer vacations and staffing shortages, it shouldn't really take two months). Good luck!

Maria Fisher46 said:Dear user,

It is now time to rule out any potentially malignant causes for this constellation of findings you have presented. Let us hope the test results do not lead in that direction. Not everyone has to wait two months for all results to arrive. Cytology results are typically ready very quickly, and immunophenotyping results usually follow shortly thereafter. While FISH and karyotype testing may take a bit longer, you might want to inquire about the cytology (often available one or two days after the biopsy) and the immunophenotyping (usually within a week, though timelines may vary due to seasonal staffing changes or holidays, but certainly not two months). Best of luck.

Thank you for your response.

CYTOLOGY RESULTS:

Myelogram: blasts 2%, promyelocytes 4%, myelocytes 9%, metamyelocytes 4%, non-segmented granulocytes 17%, segmented granulocytes 19%, lymphocytes 14%, monocytes 1%, erythroblasts 30%

DIFKS segmented granulocytes 42%, lymphocytes 47%, monocytes 8%, eosinophils 3%, E: normocytic, normochromic. Trace amount present.

In the bone marrow aspirate smears, moderately abundant hematopoietic tissue was found, where the ratio of white to red lineages is approximately 2.3:1 in favor of the white lineage. Erythropoiesis is mature and predominantly normoblastic. Granulopoiesis is represented by mature and transitional forms. Thrombopoiesis is represented by mature megakaryocyte forms.

If you could please clarify the findings above, and explain what will be determined via tissue phenotyping, FISH, and karyotype.

Thank you.

Best regards,

Carl Thompson26 said:Thanks for the reply.

CYTOLOGY REPORT:

Myelogram: blasts 2%, promyelocytes 4%, myelocytes 9%, metamyelocytes 4%, non-segmented granulocytes 17%, segmented granulocytes 19%, lymphocytes 14%, monocytes 1%, erythroblasts 30%

DIFKS segmented granulocytes 42%, lymph 47%, mono 8%, eos 3%, E: normocytic, normochromic. Trace BO

In the bone marrow aspirate smears, moderately abundant hematopoietic tissue was found, where the ratio of white to red marrow is approximately 2.3:1 in favor of the white marrow. Erythropoiesis is mature and predominantly normoblastic. Granulopoiesis is represented by mature and transitional forms. Thrombopoiesis is represented by mature megakaryocyte forms.

If you could clarify the findings above, and what is being determined via tissue phenotyping, FISH, and karyotype.

Thanks

Best regards

Hello,

As I mentioned previously—and your doctors have likely already told you—one of the reasons for investigating lymphopenia is to rule out malignant bone marrow diseases, such as myelodysplastic syndromes. The tests requested are specifically used to diagnose those conditions.

The full battery of tests must be completed before we can officially rule out those serious illnesses.

Based strictly on the bone marrow aspirate results provided, there are currently no signs of such diseases. However, we still need to wait for the remaining results.

My mother is 67. She was discharged from the hospital about three weeks ago following a bout of pneumonia, at which time her hemoglobin was normal at 137. They also detected a significant heart murmur, though we haven't looked into that yet. After a week, she started feeling weak, and it’s been getting progressively worse. Her blood work now shows a hemoglobin level of only 47. She has received four transfusions and seems to be feeling a bit better now. She is still hospitalized, so I don't have any other lab results on hand. They aren't seeing any evidence of internal bleeding.
She has diabetes and, until recently, had high blood pressure, though it's currently normal to low. Over the last five years, she experienced two major nosebleeds that required hospitalization, but she hasn't had any issues like that lately.
About a year and a half ago, she dealt with similar symptoms, and they found a polyp and some ulcers in her stomach. The polyp was removed, and her latest gastroscopy came back clear. She is waiting on a colonoscopy, but since there's no intestinal bleeding, I assume that might be fine too. What else could this be? Does anyone here have experience with something like this?
How is such a rapid drop in hemoglobin even possible? A follow-up X-ray shows the pneumonia is still sitting in the same spot.